Tim F. Greten, M.D.

Tim F. Greten, M.D.
Deputy Chief
Senior Investigator
Head, Gastrointestinal Malignancy Section

Dr. Greten is an expert in gastrointestinal (GI) oncology and tumor immunology. His specific research focus is liver cancer and immunology. He is trying to better understand how tumors in the liver interact with the immune system. Dr. Greten received his training in medical oncology, gastroenterology and hepatology in Germany and he has been performing basic and translational research studies in tumor immunology for more than 20 years. He is currently studying novel immune-based approaches to treat patients with primary hepatobiliary tumors and patients with tumors of the GI tract metastasizing into the liver.

Areas of Expertise
1) gastrointestinal cancer 2) tumor immunology and immunotherapy 3) hepatocellular carcinoma 4) liver immunology and cancer 5) preclinical and translational studies

Contact Info

Tim F. Greten, M.D.
Center for Cancer Research
National Cancer Institute
Building 10, Room 3B43
Bethesda, MD 20892
Ph: 301-451-4723

Dr. Greten combines his medical expertise in gastroenterology, hepatology and medical oncology with his research expertise in tumor immunology. His research can be best described by the three terms “liver”, “cancer “ and “immunology”. Dr. Greten and his team try to better understand how tumors in the liver interact with the immune system and he utilized this knowledge to develop better treatment options for patients with tumors of the GI tract. Dr. Greten is an expert on immune suppressor mechanisms occurring in patients with liver cancer (and murine models of liver cancer) such as regulatory T cells (Tregs) and myeloid derived suppressor cells (MDSC). In 2016 he published a landmark study on the role of fatty liver disease and CD4 T cells in HCC in Nature. Dr. Greten is also principle investigator of a number of immunotherapy trials in patients with GI cancer.

Scientific Focus Areas:
Cancer Biology, Clinical Research, Immunology
  1. Ma C, Kesarwala AH, Eggert T, Medina-Echeverz J, Kleiner DE, Jin P, Stroncek DF, Terabe M, Kapoor V, ElGindi M, Han M, Thornton AM, Zhang H, Egger M, Luo J, Felsher DW, McVicar DW, Weber A, Heikenwalder M, Greten TF.
    Nature. 531: 253-7, 2016. [ Journal Article ]
  2. Eggert T, Wolter K, Ji J, Ma C, Yevsa T, Klotz S, Medina-Echeverz J, Longerich T, Forgues M, Reisinger F, Heikenwalder M, Wang XW, Zender L, Greten TF.
    Cancer Cell. 30: 533-47, 2016. [ Journal Article ]
  3. Duffy AG, Ulahannan SV, Makorova-Rusher O, Rahma O, Wedemeyer H, Pratt D, Davis JL, Hughes MS, Heller T, ElGindi M, Uppala A, Korangy F, Kleiner DE, Figg WD, Venzon D, Steinberg SM, Venkatesan AM, Krishnasamy V, Abi-Jaoudeh N, Levy E, Wood BJ, Greten TF.
    Journal of Hepatology. 2016. [ Journal Article ]
  4. Hoechst B, Ormandy LA, Ballmaier M, Lehner F, Krüger C, Manns MP, Greten TF, Korangy F.
    Gastroenterology. 135: 234-43, 2008. [ Journal Article ]
  5. Kapanadze T, Gamrekelashvili J, Ma C, Chan C, Zhao F, Hewitt S, Zender L, Kapoor V, Felsher DW, Manns MP, Korangy F, Greten TF.
    J. Hepatol. 59: 1007-13, 2013. [ Journal Article ]

Tim F. Greten, M.D., received his medical training at Christian Albrechts University in Kiel, Germany in 1993.  He did his internship in Munich followed by a 3-year postdoctoral fellowship at the Johns Hopkins University (Baltimore, Maryland), in the laboratory of Drew Pardoll and Liz Jaffee, where he initiated his work in the field of tumor immunology.  In 1999 Dr. Greten returned to Hannover Medical School, where he finished his training in Internal Medicine (2003), Medical Oncology (2004) and Gastroenterology (2007). He held an Associate Professor position in the Department of Gastroenterology, Hepatology and Endocrinology.  In February 2010 Dr. Greten joined CCR's Medical Oncology Branch as head of the Gastrointestinal Malignancy Section and was promoted as a tenured Senior Investigator in 2015.

Dr. Greten has published more than 150 peer-reviewed papers on basic tumor immunology, translational research studies in hepatocellular carcinoma (HCC) as well as on clinical trials in different gastrointestinal malignancies, including HCC. Currently, Dr. Greten serves on the Center of Excellence in Immunology Steering Committee and Center for Advanced Preclinical Research oversight committee. He is a Chairperson of the CCR Scientific Protocol Review. 

Name Position
Haleluya Yimamu Patient Care Coordinator (Contr)
Zachary Brown O.D. Clinical Fellow
Suzanne Fioravanti R.N., B.S.N., O.C.N. Research Nurse Specialist
Charalampos Floudas M.D. Clinical Fellow
Qiong Fu Ph.D. Postdoctoral Fellow (CRTA)
Bernd Heinrich Ph.D. Postdoctoral Fellow (Visiting)
Walter (Chunwei) Lai M.D. Clinical Fellow
Chi Ma Ph.D. Staff Scientist
Donna Mabry Hrones C.R.N.P. Nurse Practitioner
Maria Pia Morelli M.D. Clinical Fellow
Umberto Rosato Ph.D. Postdoctoral Fellow (Visiting)
Varun Subramanyam Postbaccalaureate Fellow (CRTA)
Melissa A. Walker R.N. Research Nurse Specialist
Sophie (Chunhui) Wang Biologist
Changqing Xie M.D. Clinical Fellow
Qianfei Zhang Ph.D. Postdoctoral Fellow (Visiting)


Dr. Greten's study on NAFLD and HCC as been recognized as one of the top cancer-research milestones CCR investigators have reached in the last year.