Near-infrared compounds for visualizing enzymatic activity in living organisms

New fluorescent probes developed that can help clinicians pinpoint cancer metastases

New chemical compounds developed by CCR researchers and clinicians are safe and highly effective in fluorescently highlighting microscopic metastases. The new compounds could have great utility in complex living systems based on experiments done in mouse models of metastatic human ovarian cancer. Read more...

Colon cancer cells

Clinical trial studies combination immunotherapy for colorectal cancer

Sep 29, 2020

Colorectal cancer (CRC) affects the colon and rectum, which are located at the lower end of the digestive tract. One of the most common cancers, it often spreads to the liver. Because treatments that aim to use the patient’s own immune system to attack mCRC have not been very successful so far, investigators are leading a study that combines two different types of immunotherapy to see if one can enhance the effect of the other. Read more...

Mediator

Registration Open: Enhancers, Gene Regulation and Genome Organization

Sep 28, 2020

Registration is now open for the upcoming Enhancers, Gene Regulation and Genome Organization symposium. The goal of this meeting is to critically address the wealth of new data generated by bulk and single-cell molecular, imaging and computational approaches that are increasingly revealing how the genome folds to faithfully accommodate gene expression programs and cell fate decisions. The goal is to advance an understanding of how transcriptional enhancers function, how to separate cause and effect, and to identify critical questions that will guide future directions. Sessions Include: Enhancer Genetics, Enhancers in Development, Enhancer Biophysics, Enhancer in Disease and Enhancers and ncRNA. Read more...

Autumn Schierling

Selumetinib offers hope as first FDA-approved treatment for neurofibromatosis 1 (NF1)

Sep 22, 2020

Autumn Schierling is one of 50 children who have been participating since 2015 in a clinical trial of neurofibromatosis type 1 (NF1) at the NIH Clinical Center. In March 2020, the results of the trial were published and in April the FDA approved selumetinib as the first treatment for NF1. Brigitte Widemann, M.D., Chief of the Pediatric Oncology Branch who started conducting clinical trials for NF1 in 2001 was quoted as saying, “The medication’s approval is ‘huge progress’ and we will work to make more progress.” Read more...

Adapted "Schema of in vivo working model between T-cells, NK cells and macrophages and Avelumab during antitumor immune response

Clinical trial evaluates a combination therapy for metastatic clear cell renal carcinoma

Sep 21, 2020

Kidney cancer is the 6th most common cancer diagnosed in the United States with greater than 73,000 new cases seen each year. CCR investigators are interested in studying a combination immunotherapy for its most common subtype, clear cell renal carcinoma, using Avelumab and interleukin (IL)-15. Read more...

Larry Keefer

In Memoriam: Larry K. Keefer, Ph.D.

Sep 18, 2020

The Center for Cancer Research mourns the recent death of past colleague Larry K. Keefer. He made major contributions to the understanding of the chemistry of the carcinogenic nitrosamines. Read more...

Cancer immunotherapy

Clinical trial evaluates immunotherapy for head and neck cancer caused by HPV

Sep 17, 2020

A clinical trial, led by Christian Hinrichs, studies neoadjuvant immunotherapy for HPV-related head and neck cancer. Neoadjuvant means it is given before main treatments such surgery. The goal of the study is to see if T cells given before the main treatment can reduce the risk of the disease coming back and to convert borderline or unresectable tumors to resectable. Read more...

Description of metastasis

Trial opens to evaluate a potential anti-metastasis compound

Sep 14, 2020

The Center for Cancer Research has opened a phase I trial to evaluate the safety and clinical activity of metarrestin, a compound that suppressed metastasis and extended survival in several preclinical cancer models. Read more...

kaposi sarcoma cells

Clinical trial will evaluate chemotherapy-sparing approach to treating Kaposi sarcoma

Sep 10, 2020

CCR physician-scientists have launched a clinical trial to evaluate whether the immune-stimulating molecule NHS-IL12, alone or in combination with an experimental immunotherapy called M7824, reduces tumors in patients with Kaposi sarcoma. Read more...

Brandon Ogbunu

Undergraduate research at NCI sparks curiosity and new connections

Sep 10, 2020

Brandon Ogbunu, a Professor of Ecology and Evolutionary Biology at Yale, recalls the time he spent studying gene regulation in Susan Gottesman’s lab. He says the experience sparked interests that have helped shape his career studying evolution and disease. Read more...

neutrophils

Innovative imaging tools reveal how neutrophils fight inflammation in mice

Sep 9, 2020

CCR researchers used state-of-the-art imaging techniques to observe, in real time, the path neutrophils take as they move toward a site of inflammation in a mouse model. The images showed the neutrophils leaving the blood vessels and engaging with bacteria that had been introduced into the mouse’s footpad. These observations led to the team’s discovery that the leukocyte LTB4 directs the recruitment, engagement, and penetration of neutrophils into inflamed tissues. Read more...

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