Cartoon of patients receiving stem cells
Clinical trial evaluates blood stem cell transplantation for patients with T-cell disorders

T cells, a type of white blood cell, develop from stem cells, mature in the thymus gland and play a key role in human immunity by protecting the body from infection. They may also help to fight cancer. People whose T cells fail to properly develop or function can develop imbalances in the immune system that lead to cancer, autoimmune disease and other problems. Jennifer Kanakry, M.D., of the Experimental Transplantation and Immunology Branch is leading a study that transplants allogeneic blood-forming stem cells from healthy donors into patients with T-cell disorders. Read more...

Hussain

S. Perwez Hussain tenured and promoted to Senior Investigator

May 24, 2018

S. Perwez Hussain, Ph.D., has been granted tenure at NIH and appointed to Senior Investigator in the Laboratory of Human Carcinogenesis (LHC). Dr. Hussain's laboratory utilizes a combination of global and targeted translational research strategies, focused on inflammatory mediators, to examine the underlying mechanisms of human pancreatic cancer progression and understand the mechanistic and functional role of a gene or pathway associated with patient’s outcome.  Read more...

S. Perwez Hussain tenured and promoted to Senior Investigator
Pancreatic cancer

Clinical trial investigates experimental drug for advanced pancreatic cancer

May 23, 2018

The pancreas, a large gland that sits behind the stomach, produces enzymes that aid digestion and hormones that regulate blood sugar. Pancreatic cancer develops when cells that make up the ducts in the pancreas start to grow out of control. Udo Rudloff, M.D., is leading a clinical trial of a combination immunotherapy regimen to optimally help the immune system attack the tumor. Read more...

brain tumor facebook live

Facebook Live: Adult brain and spine tumor research and treatment

May 23, 2018

Please join us for a Facebook Live on adult brain and spine tumor research and treatment May 25 at 11:00 a.m. ET.. The conversation will focus on primary central nervous system (CNS) tumors, meaning the tumor begins in the brain or spinal cord. Mark Gilbert, M.D., Chief, and Terri Armstrong, M.D., Senior Investigator, both from the Neuro-Oncology Branch, will be joined by moderator and Chief Executive Officer, David Arons, of the National Brain Tumor Society.  Read more...

Facebook Live: Adult brain and spine tumor research and treatment
SIV

Selectively engaging immune responses may be key to fighting HIV infection

May 22, 2018

An infection-fighting white blood cell known as a CD14+ monocyte could be a key element in developing an effective human immunodeficiency virus (HIV) vaccine, according to a new finding published May 21, 2018, in Nature Medicine. The primate study was conducted at the Center for Cancer Research, NCI, and led by Genoveffa Franchini, M.D., Senior Investigator in the Vaccine Branch. Read more...

T cell

New trial engineers immune cells to treat solid tumors

May 18, 2018

No existing systemic treatments can currently eradicate the great majority of metastatic solid cancers. To meet that need, Steve Rosenberg, M.D., Ph.D., is testing a new immunotherapy that targets each tumor’s unique genetic mutations in a clinical trial. Read more...

Epstein-Barr virus

New clinical trial uses targeted cancer drug for lymphatic system disease

May 16, 2018

Nivolumab is a targeted cancer drug that blocks the action of a protein called PD-1 and activates T cells to attack cancer cells without damaging normal cells. Mark Roschewski, M.D., of the Lymphoid Malignancies Branch is leading a study to determine if nivolumab is effective in treating patients with certain diseases of the lymphatic system. Read more...

Liver cancer

Scientists develop potential new approach against cancer metastasis

May 16, 2018

A collaboration between the National Institutes of Health Intramural Research Program, Northwestern University and their collaborative research partners has identified a compound called metarrestin that blocks the spread of pancreatic and other cancers in animal models. Mice treated with metarrestin also had fewer tumors and lived longer than mice that did not receive treatment. The results of this study were published in Science Translational Medicine on May 16, 2018, and described in a press release from the NIH’s National Center for Advanicing Translational Sciences (NCATS).  Read more...

Scientists develop potential new approach against cancer metastasis
HPV

Clinical trial tests first-in-class bifunctional immunotherapy drug in HPV-associated cancers

May 14, 2018

HPV-associated cancers that spread or do not respond to treatment are often incurable. Julius Strauss, M.D., of the Laboratory of Tumor Immunology and Biology is testing a first-in-class bifunctional immunotherapy to see if it can control the growth of HPV-associated tumors by restoring and improving the immune system’s ability to kill cancer cells. Read more...

Joana Vidigal, Ph.D.

Joana Vidigal joins CCR as NIH Stadtman Investigator

May 14, 2018

Joana Vidigal, Ph.D. has joined the Laboratory of Biochemistry and Molecular Biology (LBMB) as a Stadtman Tenure Track Investigator. Dr. Vidigal's research focuses on understanding the mechanisms through which small noncoding RNA pathways regulate gene expression during animal development, tissue homeostasis, and disease and she uses mouse models and genetic tools together with biochemical and computational approaches to stringently define the requirement of these pathways in vivo. Learn more...

Joana Vidigal joins CCR as NIH Stadtman Investigator
Eros Lazzerini Denchi, Ph.D.

Eros Lazzerini Denchi joins CCR as NIH Stadtman Investigator

May 14, 2018

Eros Lazzerini Denchi, Ph.D. has joined the Laboratory of Genome Integrity (LGI) as a Stadtman Tenure Track Investigator. Dr. Lazzerini Denchi's research focuses on two fundamental aspects of telomere biology: the mechanism by which functional telomeres prevent DNA damage activation and the in vivo consequences of telomere dysfunction. Learn more...

Eros Lazzerini Denchi joins CCR as NIH Stadtman Investigator

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