New findings show how damaged cells survive the cell cycle

As cells divide and replicate, important safety checkpoints are in place to ensure that most faulty cells with damaged DNA do not survive the cell cycle. In a new twist, CCR researchers discovered how some damaged cells use molecular inertia to drive past these safety checkpoints and continue through the cell cycle. Read more...

HIV cell

Trial shows aggressive cancer treatment is appropriate for people with HIV-associated primary central nervous system lymphoma

Jul 2, 2020

New research from CCR scientists shows that chemoimmunotherapy with antiretroviral therapy can lead to long-lasting remissions of HIV-associated primary central nervous system lymphoma without compromising neurocognitive function. Read more...

patient scan

Study finds drug beneficial for shrinking mesothelioma tumors

Jul 1, 2020

A drug that is designed to boost the immune system against mesothelioma, when combined with immunotherapy, was found to be beneficial in a small study involving ten patients. The results suggest that the drug LMB-100 could prolong the life of some patients with advanced disease. Read more...

Antibody-dependent cell-mediated cytotoxicity

Clinical trial studies combination therapy for certain mature T-cell cancers that have not responded to treatment

Jul 1, 2020

Adult T-cell leukemia/lymphoma (ATLL) and mycosis fungoides/Sézary syndrome (MF/SS) are fast-growing cancers that form in T cells, a type of white blood cell that is key to the body’s immune response. A clinical trial is being conducted at the NIH Clinical Center to test a combination therapy for these rare cancers. Read more...

Patient scan

Clinical trial tests targeted radioactive agent as therapy for metastatic prostate cancer

Jun 26, 2020

Prostate-specific membrane antigen (PSMA) is present on the surface of all prostate cancer cells but is highly expressed on cells of castration-resistant prostate cancer (mCRPC). Frank Lin, M.D., Investigator in the the Molecular Imaging Program, is leading NCI’s effort to study the effect of targeted treatment with a radioactive agent to test dosing and overall effect for these patients. Read more...

Christina Annunziata

A Conversation with Christina Annunziata, M.D., Ph.D.

Jun 25, 2020

Christina Annunziata, M.D., Ph.D., is an Investigator in the Women’s Malignancies Branch at the Center for Cancer Research. She has spent most of her career studying the molecular underpinnings of ovarian cancer with the goal of discovering novel treatments. In our Q&A, Dr. Annunziata discusses her personal and professional milestones as well as new directions for her research. Read more...


Clinical trial studies immunotherapy for head and neck cancer caused by HPV

Jun 24, 2020

Head and neck cancer caused by the human papillomavirus is being studied in a clinical trial led by Christian S. Hinrichs, M.D., Senior Investigator in the Genitourinary Malignancies Branch. This study will evaluate T-cell immunotherapy for safety without delaying standard treatments (surgery or radiation with chemotherapy). Read more...

chemical structure of RNA

New chemical sequencing reaction helps unravel the role of an ancient RNA modification

Jun 23, 2020

CCR researchers and collaborators have developed a novel chemical reaction that enables the quantitative mapping of an ancient and enigmatic RNA modification that is found in nearly all organisms on earth, providing fundamental insights that are potentially important for tumor biology and cancer treatment. Read more...

CAR T-cell therapy

Clinical trial studies CAR T-cell therapy for relapsed/refractory acute myeloid leukemia

Jun 22, 2020

Acute myeloid leukemia (AML) is a cancer of the blood and bone marrow, the soft inner part of long bones where new blood cells are made. With AML, bone marrow cells don't grow the way they're supposed to. Instead, immature bone marrow cells grow uncontrollably and build up in the body. This study is testing the effect of chimeric antigen receptor T cells (CAR T cells) for children and young adults. Read more...

Peritoneal carcinomatosis

New clinical trial evaluates chemotherapy delivery for stomach cancer

Jun 18, 2020

A clinical trial testing chemotherapy delivery for stomach cancer that has spread to the lining of abdominal cavity is underway at the NIH Clinical Center. Investigators are evaluating how this delivery may improve outcomes for patients with this rare condition. Read more...

AACR 2020 logo

CCR presentations at AACR 2020 - Session II

Jun 16, 2020

The American Association for Cancer Research (AACR) Annual Meeting covers the latest discoveries across the spectrum of cancer research—from population science and prevention; to cancer biology, translational, and clinical studies; to survivorship and advocacy—and highlights the work of the best minds in research and medicine from institutions all over the world. The 2020 AACR Virtual Annual Meetings I and II will take place April 27-28 and June 22-24, respectively. View the list of CCR presenters for the June meeting.