A Conversation with Bríd Ryan, Ph.D., M.P.H.

Bríd Ryan, Ph.D., M.P.H., is an NIH Stadtman Investigator in the Laboratory of Human Carcinogenesis at the Center for Cancer Research. Her research focuses on health disparities related to lung cancer across different populations. She discusses her latest research findings and future directions of her work as well as the importance of the supportive CCR environment in this Q&A. Read more...

Pancreatic cancer cells

Clinical trial will test new treatment to improve survival rates for patients with operable gastrointestinal tumors

Oct 28, 2019

A clinical phase II trial at the NIH Clinical Center will test the effectiveness of a monoclonal antibody used immediately before and after surgery for patients with primary pancreatic and bile duct cancer and those who have liver metastasis from colorectal cancer. The trial is investigating whether this treatment can prevent the disease from coming back after surgery. Read more...

liver anatomy

Clinical trial studies antibiotic therapy for fibrolamellar hepatocellular carcinoma, a rare liver cancer

Oct 25, 2019

Fibrolamellar hepatocellular carcinoma (FLC) is a rare liver cancer that usually grows in teens and young adults. Unresectable FLC usually does not improve with surgery, chemotherapy or radiation therapy. Tim F. Greten, M.D., Deputy Chief of the Thoracic and GI Malignancies Branch, is leading a study that tests the theory that certain bacteria in the gut may influence the development of FLC. Read more...

James Kochenderfer

James Kochenderfer receives 2019 FNIH Trailblazer Prize for Clinician-Scientists

Oct 24, 2019

James Kochenderfer, M.D., Investigator in the Surgery Branch, has received the 2019 Foundation for the National Institutes of Health (FNIH) Trailblazer Prize for Clinician-Scientists. The award recognizes the outstanding contributions of early career clinician-scientists whose work has the potential to or has led to innovations in patient care. Dr. Kochenderfer was selected as the 2019 recipient for developing immunotherapies that leverage chimeric antigen receptor (CAR) T cells to treat blood cancers, including lymphoma and multiple myeloma. Read more...

Samantha Seinfeld

Metastatic breast cancer survivor shares her clinical trial story

Oct 23, 2019

We’re celebrating breast cancer awareness month by sharing the story of Samantha Seinfeld, a metastatic breast cancer survivor who participated in a CCR first-in-human clinical trial over 10 years ago. Since then, she has remained cancer-free. Margaret Gatti-Mays, M.D., M.P.H., F.A.C.P., Assistant Research Physician in the Laboratory of Tumor Immunology and Biology, and James Gulley, M.D., Ph.D., Chief of the Genitourinary Malignancies Branch, are currently evaluating Samantha’s unusual immune response in hopes of improving the responses of other patients. Read more...

Reddit logo

Stanley Lipkowitz and Alexandra Zimmer answer breast cancer “Redditor” questions

Oct 22, 2019

Stanley Lipkowitz, M.D., Ph.D., Chief of the Women’s Malignancies Branch (WMB), and Alexandra Zimmer, M.D., Assistant Research Physician in WMB, recently answered questions about breast cancer during a Reddit “Ask Me Anything” (AMA). During the event, Drs. Lipkowitz and Zimmer discussed topics ranging from recent advances in breast cancer treatment to genetic and environmental factors that influence risk for disease. Read more...

Kenneth Aldape

Kenneth Aldape discusses importance of precise diagnosis in brain and spine tumors

Oct 22, 2019

Kenneth Aldape, M.D., Chief of the Laboratory of Pathology, recently discussed the importance of a precise diagnosis in the treatment of brain and spine tumors in an NCI-CONNECTions blog. In the blog, he shares how he’s using the latest technologies and techniques to provide more individualized care for patients.  Read more...

Andre Nussenzweig

Andre Nussenzweig elected to the National Academy of Medicine

Oct 21, 2019

Andre Nussenzweig, Ph.D., Chief of the Laboratory of Genome Integrity, has been elected to the National Academy of Medicine (NAM), one of the highest honors in the fields of health and medicine. Dr. Nussenzweig was elected to NAM for making seminal discoveries that speak to how cells maintain their own genome stability, allow chromosome fragility and license leukemogenesis at the hands of aberrant DNA repair. Read more...

Large B-cell lymphoma

Clinical trial studies combination therapy for B-cell lymphoma that has spread to the central nervous system

Oct 15, 2019

Mark Roschewski, M.D., Senior Clinician in the Lymphoid Malignancies Branch, is leading a study of a combination therapy to treat aggressive B-cell lymphoma that has spread to the brain and spinal cord. Read more...

Bone anatomy

Clinical trial tests chemotherapy dose for graft-versus-host disease after bone marrow transplant

Oct 11, 2019

The use of cyclophosphamide after hematopoietic cell transplantation (post-transplantation cyclophosphamide) may reduce the risk of severe forms of graft-versus-host disease (GVHD), particularly chronic GVHD. Christopher G. Kanakry, M.D., Investigator in the Experimental Transplantation and Immunology Branch, is conducting a clinical trial to test if an intermediate dose of this drug is better than higher doses as well as evaluating the optimal time to give this drug. Read more...

Tim Greten

Tim Greten discusses liver cancer with OncLive

Oct 7, 2019

Tim Greten, M.D., Deputy Chief of the Thoracic and GI Malignancies Branch, was recently interviewed by OncLive. In the interview, Dr. Greten discussed the role of the gut microbiome in antitumor immunity in liver cancer.  Read more...