News and Events
Celebrating CCR Careers: Alan Rein, Ph.D.
Alan Rein, Ph.D., is a known expert in the field of viral assembly, particularly in retroviruses like the human immunodeficiency virus (HIV). After an extensive career studying molecular mechanisms of retroviral replication and pathogenesis, he has announced his retirement.
Read MoreLiving with and learning about neuroendocrine tumors: A conversation with Dr. Jaydira Del Rivero
Jaydira Del Rivero, M.D., Assistant Research Physician in the Developmental Therapeutics Branch, studies neuroendocrine tumors – a rare group of malignant neoplasms that originates from neuroendocrine cells and affects almost any part of the body. In this Q&A, Dr. Del Rivero and a natural history trial participant discuss an ongoing neuroendocrine study and their experiences at NIH.
Read MoreFollowing the fellowship experience with CCR fellow Bailey Johnson
Bailey Johnson is a postbaccalaureate fellow in the Laboratory of Cell Biology. For this Black History Month Q&A, we asked her about her research journey, personal goals and advice for the next generation of students of color.
Read MoreClinical trial evaluates drug for treatment of neurofibromatosis type 1 and atypical neurofibromas
Up to half of the people with neurofibromatosis type 1 develop plexiform neurofibromas (PNs), tumors that grow along nerves. Over time, PNs may transform into atypical neurofibromas (ANFs) and then into cancerous tumors. Andrea Gross, M.D., Assistant Research Physician in the Pediatric Oncology Branch, is leading a study of a drug, abemaciclib, to treat ANFs in children.
Read MoreClinical trial compares interval dosing of two immune checkpoint inhibitors
William D. Figg Sr., Pharm.D., Deputy Chief of the Genitourinary Malignancies Branch, is leading CCR’s efforts in a multi-institution, international study comparing methods of dosing nivolumab and pembrolizumab. This study is intended for people who have advanced or metastatic cancer that has not been previously treated with an immune checkpoint inhibitor.
Read MoreUnique gene expression profiles identify rare T cells that could be effective in cancer immunotherapy
CCR researchers led by Steven A. Rosenberg, M.D., Ph.D., Chief of the Surgery Branch, have found unique expression profiles in 50 genes that help identify rare anti-tumor lymphocytes that can be used as personalized immunotherapy in many patients with metastatic solid tumors.
Read MoreNCI study advances personalized immunotherapy for metastatic breast cancer
An experimental form of immunotherapy that uses an individual’s own tumor-fighting immune cells could potentially be used to treat people with metastatic breast cancer, according to results from an ongoing clinical trial led by Steven A. Rosenberg, M.D., Ph.D., Chief of the Surgery Branch.
Read MoreAll about the drive: A rare kidney cancer meets its match at NIH
On New Year’s Eve, 2020, Katie Coleman was diagnosed with a very rare form of advanced kidney cancer. She enrolled in a clinical trial led by a collaborative CCR team that gave her the opportunity to have surgery in hopes of removing her tumors.
Read MoreResearchers develop new method to estimate cell-type-specific information from bulk tumor data
CCR researchers have established a way to extract cell-type-specific expression information from bulk gene expression data of a tumor sample. Their computational approach, which outperforms comparable state-of-the-art methods, evaluates thousands of tumor samples with minimal cost.
Read MoreBreast cancer stem cells become aggressive upon contact with macrophages
New findings suggest that breast cancer cells gain stem-like characteristics of invasiveness, aggressiveness and drug resistance upon contact with macrophages, specialized white blood cells in the immune system.
Read MoreA high-fiber diet may improve the response of melanoma patients to immunotherapy
A new study co-led by Giorgio Trinchieri, M.D., chief of the Laboratory of Integrative Cancer Immunology, found that a diet rich in fiber may help some people being treated for melanoma respond to immunotherapy treatment by influencing the gut microbiome. The new findings come from an analysis of people with melanoma and mouse models of the disease.
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