News and Events

Clinical trial researches drug therapy for bone marrow neoplasms

A clinical trial led by Steven Z. Pavletic, M.D., Senior Clinician in the Immune Deficiency Cellular Therapy Program, is researching a therapy for myelodysplastic syndromes (MDS), a group of bone marrow neoplasms.

Scan of bone marrow from mice with non-alcoholic fatty liver disease

Liver cancer may unexpectedly be influenced by platelets

Platelets have long been associated with more aggressive cancers; however, new results show that these cell fragments release molecules with anti-tumor properties against liver cancer, reducing tumor burden in mice. The results provide detailed insights into the mysterious role of platelets in cancer progression.

Clinical trial researching therapy for prostate cancer

A clinical trial led by Ravi A. Madan, M.D., Senior Clinician in the Genitourinary Malignancies Branch, is researching a combination drug therapy for prostate cancer.

Stock image of female African-American doctor with female patient in office setting.

Clinical trial researching therapy for cancers of the reproductive system

A clinical trial led by Jung-Min Lee, M.D., Lasker Clinical Research Scholar in the Women’s Malignancies Branch, is researching a combination drug therapy for cancers of the ovaries, fallopian tubes or peritoneum.

TOP3B (pink structure) and DDX5 (green structure) are working together to unwind and cut a tangled R-loop.

Study finds that enzyme can disentangle strands of DNA and RNA

R-loops are three-stranded hybrid structures of DNA and RNA that play important regulatory functions in cells. Tangled R-loops can cause a number of issues in the genome and subsequently affect people’s health. CCR researchers have uncovered the mechanisms that the enzyme topoisomerase 3B uses to disentangle problematic R-loops.

Photomicrograph of a diffuse large B-cell lymphoma

New insights into the origins of an aggressive form of lymphoma

A new study sheds light on the origin of an aggressive subtype of diffuse large B cell lymphoma (DLBCL). The findings could help researchers develop more targeted therapies for this form of blood cancer.

Bacteria inside lung tumors concentrate within cancer cells

Researchers discovered that tumor-promoting signals are elevated in lung tumor cells with high concentrations of bacteria. These findings support the idea that reducing bacteria in the lungs might be beneficial for patients with lung cancer.

Cytotoxic T cells (red) are shown attacking a squamous cancer cell (white).

Immune receptors recognizing mutations in p53 could guide immunotherapies for solid tumors

CCR scientists have assembled a library of immune receptors that direct T cells to target cells with mutations in p53, the most commonly mutated gene in human cancers.

CCR postdoctoral researcher awarded Fulbright to study HPV and cervical cancer in Africa

Tsion Minas, Ph.D., is a recent recipient of a Fulbright U.S. Scholar Award. She joined the Laboratory of Human Carcinogenesis in 2016 to work with Senior Investigator Stefan Ambs, Ph.D., M.P.H., and study the molecular nature of cancers in African populations. In this Q&A, she shares her passion for closing disparity gaps in health research and how she plans to build upon her Fulbright work in the future.

Microscopic view of a tissue sample of ductal cell carcinoma from human breast cancer. Image credit: Allan Weissman, M.D., Senior Investigator in the Cancer Innovation Laboratory at CCR, and Kevin Gardner, M.D., Ph.D., Professor of Pathology and Cell Biology at Columbia University.

A protein predicts poor breast cancer survival for women of African descent

CCR and Columbia University researchers have discovered that large amounts of the gp78 protein in breast cancer tumors predict worse outcomes for patients of African ancestry. Their findings provide some new understanding of a significant health disparity in breast cancer.

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