Clinical Trials

Clinical trial tests vaccine for late-stage HPV-linked tumors

The human papillomavirus (HPV) has been linked to many kinds of cancer, including cervical, uterine, vaginal, penile and oropharyngeal. For those who develop advanced HPV-linked cancer, the NIH Clinical Center has a clinical trial open to test a vaccine with and without checkpoint inhibitors to see if this treatment approach can stop tumor growth.

Lymphoma therapy drug tested as early treatment for chronic graft-versus-host disease

cGvHD can occur after a person has had a stem cell or bone marrow transplant. In some cases, the donated bone marrow/stem cells view the host's body as foreign and start to attack it. cGvHD can occur at any time after a transplant, but it's more common after the marrow/stem cells have created a new immune system in the host's body. A clinical trial is studying the lymphoma therapy drug ibrutinib to see if early treatment can prevent the most severe symptoms of cGvHD.

Combination therapy for solid tumors and small-cell cancers studied in new clinical trial

A clinical trial of a drug combination to treat solid tumors and small-cell cancers is being conducted at the NIH Clinical Center. PARP inhibitors can work better when combined with chemotherapy, such combinations can be too toxic, so this study uses a new kind of chemotherapy called PLX038 and combines it with a PARP inhibitor rucaparib to see if the combination of PLX038 and rucaparib can safely shrink solid tumors and small-cell cancers.

Clinical trial studies combination immunotherapy for colorectal cancer

Colorectal cancer (CRC) affects the colon and rectum, which are located at the lower end of the digestive tract. One of the most common cancers, it often spreads to the liver. Because treatments that aim to use the patient’s own immune system to attack mCRC have not been very successful so far, investigators are leading a study that combines two different types of immunotherapy to see if one can enhance the effect of the other.

Adapted "Schema of in vivo working model between T-cells, NK cells and macrophages and Avelumab during antitumor immune response

Clinical trial evaluates a combination therapy for metastatic clear cell renal carcinoma

Kidney cancer is the 6th most common cancer diagnosed in the United States with greater than 73,000 new cases seen each year. CCR investigators are interested in studying a combination immunotherapy for its most common subtype, clear cell renal carcinoma, using Avelumab and interleukin (IL)-15.

Clinical trial evaluates immunotherapy for head and neck cancer caused by HPV

A clinical trial, led by Christian Hinrichs, studies neoadjuvant immunotherapy for HPV-related head and neck cancer. Neoadjuvant means it is given before main treatments such surgery. The goal of the study is to see if T cells given before the main treatment can reduce the risk of the disease coming back and to convert borderline or unresectable tumors to resectable.

Trial opens to evaluate a potential anti-metastasis compound

The Center for Cancer Research has opened a phase I trial to evaluate the safety and clinical activity of metarrestin, a compound that suppressed metastasis and extended survival in several preclinical cancer models.

Clinical trial will evaluate chemotherapy-sparing approach to treating Kaposi sarcoma

CCR physician-scientists have launched a clinical trial to evaluate whether the immune-stimulating molecule NHS-IL12, alone or in combination with an experimental immunotherapy called M7824, reduces tumors in patients with Kaposi sarcoma.

FDA grants rare pediatric disease designation for experimental immunotherapy for acute lymphoblastic leukemia

A cell-based immunotherapy that is currently being evaluated at the NIH Clinical Center for the treatment of B-cell acute lymphoblastic leukemia (ALL) has been designated by the U.S. Food and Drug Administration as a drug for a rare pediatric disease. Designation could encourage development of this novel therapy for children with relapsed or refractory ALL.

Clinical trial evaluates radiopharmaceutical as therapy for biochemically recurrent prostate cancer

Some men who have been treated for localized prostate cancer (PC) with surgery or radiation still have signs of the disease that are only detected by a blood test (a rising prostate specific antigen or PSA). This is called biochemically recurrent prostate cancer (BCRpc). Investigators in the Center for Cancer Research are leading a clinical trial exploring an option meant to be less toxic for treating BCRpc, which may impact microscopic bone disease seen only on PET scans, using radium-223.

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