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Clinical Trials

Stem cell transplant after CAR T-cell therapy effective for young leukemia patients

In a clinical trial, CCR physician-scientists found that long-term survival for young patients with B-cell acute lymphoblastic leukemia was significantly better for those who received CD19-CAR T-cell therapy followed by a stem cell transplant. As a result of these findings, use of stem cell transplant is now recommended following CAR T-cell therapy.

Manufactured CAR T cells ready for infusion into a patient

FDA approves BCMA-targeted CAR T-cell therapy for multiple myeloma

The Food and Drug Administration approved idecabtagene vicleucel (Abecma) for people with multiple myeloma that has not responded to or has returned after at least four different prior cancer treatments. The approval is based, in part, on earlier clinical work led by James N. Kochenderfer, M.D., Senior Investigator in the Surgery Branch.

Brigitte Widemann named a Top Ten Clinical Research Achievement Awardee

Brigitte C. Widemann, M.D., Chief of the Pediatric Oncology Branch, has been named a Top Ten Clinical Research Achievement Awardee by the Clinical Research Forum, and she was awarded a Distinguished Clinical Research Achievement Award for her study “Selumetinib in Children with Inoperable Plexiform Neurofibromas.”

FDA grants orphan drug designation to PRGN-2012 for recurrent respiratory papillomatosis

The Food and Drug Administration has granted orphan drug designation to PRGN-2012 immunotherapy for use in patients with recurrent respiratory papillomatosis.

High magnification micrograph of a clear cell renal cell carcinoma

Combination therapy in patients with advanced kidney cancer found to be highly effective

A phase III international clinical trial that tested the combination therapy of nivolumab and cabozantinib in patients with advanced, untreated renal-cell carcinoma yielded promising results.

Clinical trial investigates vaccine to treat recurrent respiratory papillomatosis after surgery

Scott M. Norberg, D.O., Assistant Research Physician in the Genitourinary Malignancies Branch, is leading a study of PRGN-2012, an experimental therapeutic vaccine for adults with recurrent respiratory papillomatosis (RRP). RRP is a rare disorder caused by human papillomavirus.

New trial evaluates immunotherapy combinations in adults with advanced small bowel and colorectal cancers

Julius Strauss, M.D., Assistant Research Physician in the Laboratory of Tumor Immunology and Biology, is leading a clinical trial evaluating a combination of immunotherapy drugs to see if they can shrink advanced tumors of the small bowel, colon and rectum.

Clinical trial evaluates combination therapy for men with metastatic prostate cancer

Ravi A. Madan, M.D., Senior Clinician in the Genitourinary Malignancies Branch, is leading a study of an experimental treatment for men with two types of prostate cancer: one type that responds to hormone therapy and one that doesn’t.

Clinical trial studies immunotherapy combination for recurrent thymoma and thymic carcinoma

Thymic epithelial tumors (TETs) are rare cancers that originate from the cells of the thymus, a small organ that sits in the chest between the lungs and above the heart. Arun Rajan, M.D., Senior Clinician in the Thoracic and GI Malignancies Branch, is leading a clinical trial of a therapy for thymoma and thymic carcinoma that has returned after chemotherapy and cannot be treated with surgery.

Clinical trial studies therapy for relapsed/refractory T-cell malignancies

Milos Miljkovic, M.D., M.Sc., Assistant Research Physician in the Lymphoid Malignancies Branch, is leading a study of a 4-drug combination treatment strategy using romidepsin, oral 5-azacitidine, dexamethasone and lenalidomide for T-cell malignancies (TCMs). Researchers are seeking to determine the safety, side effects, and best dose of this 4-drug combination for people with relapsed/refractory TCM.

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Clinical Trials