Scott M. Norberg, D.O.

Scott M. Norberg, D.O.
Assistant Research Physician
Genitourinary Malignancies Branch

Dr. Norberg researches the use of immunotherapy and cellular therapy for a variety of conditions including human papillomavirus-positive (HPV+) cancers and premalignant diseases caused by chronic HPV infection. His research focuses on understanding resistance to immunotherapy and cellular therapies and applying these treatment modalities to other conditions. 

Areas of Expertise

1) cell therapy, 2) immunotherapy, 3) human papillomavirus, 4) cervical cancer, 5) oropharyngeal cancer, 6) anal cancer

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Contact Info

Scott M. Norberg, D.O.
Center for Cancer Research
National Cancer Institute
Building 10, Room 3-3132
Bethesda, MD 20892
Ph: 240-858-3303
scott.norberg@nih.gov

Dr. Norberg conducts clinical research to develop T cell therapies for the treatment of patients with cancer and precancerous diseases. This includes conducting clinical trials using genetically engineered T cells to treat patients with advanced human papillomavirus (HPV) malignancies.

NIH Scientific Focus Areas:
Biomedical Engineering and Biophysics, Cancer Biology, Clinical Research, Immunology, Virology

Selected Recent Publications

  1. TCR-engineered T cells targeting E7 for patients with metastatic HPV-associated epithelial cancers.
    Nagarsheth NB, Norberg SM, Sinkoe AL, Adhikary S, Meyer TJ, Lack JB, Warner AC, Schweitzer C, Doran SL, Korrapati S, Stevanovic S, Trimble CL, Kanakry JA, Bagheri MH, Ferraro E, Astrow SH, Bot A, Faquin WC, Stroncek D, Gkitsas N, Highfill S, Hinrichs CS.
    Nat Med. 2021. Full-Text Article [ Journal Article ]
  2. Cancer targeting by TCR gene-engineered T cells directed against Kita-Kyushu Lung Cancer Antigen-1.
    Marcinkowski B, Stevanović S, Helman SR, Norberg SM, Serna C, Jin B, Gkitsas N, Kadakia T, Warner A, Davis JL, Rooper L, Hinrichs CS.
    J Immunother Cancer. 7(1): 229, 2019. [ Journal Article ]
  3. Safety and clinical activity of PD-L1 blockade in patients with aggressive recurrent respiratory papillomatosis.
    Allen CT, Lee S, Norberg SM, Kovalovsky D, Ye H, Clavijo PE, Hu-Lieskovan S, Schlegel R, Schlom J, Strauss J, Gulley JL, Trepel J, Hinrichs CS.
    J Immunother Cancer. 7(1): 119, 2019. [ Journal Article ]

Dr. Norberg received his B.S. from Saint Mary’s College of California and a M.S. in Medical Sciences at Drexel University. He received his medical degree at the Philadelphia College of Osteopathic Medicine. He completed his residency in internal medicine at Temple University Hospital and a fellowship in medical oncology at the National Cancer Institute. After fellowship training, he joined the research group of Dr. Christian Hinrichs where he conducts clinical research to develop T-cell therapies for patients with malignant and premalignant disease.

Dr. Norberg is board certified in internal medicine and medical oncology.

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