Scott M. Norberg, D.O.

Center for Cancer Research
National Cancer Institute

Building 10, Room 3-3132
Bethesda, MD 20892
240-858-3303
scott.norberg@nih.gov

Associate Research Physician

Center for Immuno-Oncology

Head, Solid Tumor Cellular Therapy Group

Team Member Of:

Acting Co-Director, Center for Cancer Research

James L. Gulley, M.D., Ph.D.

gulleyj@mail.nih.gov

RESEARCH SUMMARY

Dr. Norberg researches the use of immunotherapy and cellular therapy for a variety of conditions including human papillomavirus-positive (HPV+) cancers and premalignant diseases caused by chronic HPV infection. His research focuses on understanding resistance to immunotherapy and cellular therapies and applying these treatment modalities to other conditions.

Areas of Expertise

Colon and Rectal Cancer

Cell Therapy

Immunotherapy

Human Papillomavirus

Cervical Cancer

Oropharyngeal Cancer

Clinical Trials
Research
Publications
Biography
News

Open - Recruiting

Phase 3

Confirmatory Study of PRGN-2012 in Patients With RRP
Learn if you qualify for this trial

Trial ID
IRB001969

Trial Lead
Scott M. Norberg, D.O.

Who to Contact for Questions

Email NCI Medical Oncology Referral Office

Call 888-624-1937
Open - Recruiting

Phase 2

Bevacizumab in Adults With Recurrent Respiratory Papillomatosis (RRP)
Learn if you qualify for this trial

Trial ID
IRB001572

Trial Lead
Scott M. Norberg, D.O.

Who to Contact for Questions

Email Wheatley, Melissa L
Open - Recruiting

Phase 1

T Cell Receptor Gene Therapy Targeting KK-LC-1 for Gastric, Breast, Cervical, Lung and Other KK-LC-1 Positive Epithelial Cancers
Learn if you qualify for this trial

Trial ID
000045

Trial Lead
Scott M. Norberg, D.O.

Who to Contact for Questions

Email Parsons-wandell, Laura Ann
Open - Recruiting

Phase 1

Phase 2

E7 TCR T Cells for Human Papillomavirus-Associated Cancers
Learn if you qualify for this trial

Trial ID
16-C-0154

Trial Lead
Scott M. Norberg, D.O.

Who to Contact for Questions

Email Parsons-wandell, Laura Ann
Open - Recruiting

Collection of Peripheral Blood Mononuclear Cells (PBMCs) From Healthy People for the Expansion of T Cells for Adoptive Cell Therapy
Learn if you qualify for this trial

Trial ID
16-C-0138

Trial Lead
Scott M. Norberg, D.O.

Who to Contact for Questions

Email Parsons-wandell, Laura Ann
Open - Recruiting

Biospecimen Procurement for Center for Immuno-Oncology Immunotherapy Protocols
Learn if you qualify for this trial

Trial ID
16-C-0061

Trial Lead
Scott M. Norberg, D.O.

Who to Contact for Questions

Email Parsons-wandell, Laura Ann
Open - Not yet Recruiting

A Phase I Study of T Cell Receptor Gene Therapy Targeting KK-LC-1 for Cancers of the Stomach, Breast, Cervix, and Lung
Summary not yet available.

Trial ID
IRB001571

Trial Lead
Scott M. Norberg, D.O.
Open - Not yet Recruiting

A Phase II Trial of T Cell Receptor Gene Therapy Targeting HPV-16 E7 for HPV-Associated Cancers.
Summary not yet available.

Trial ID
IRB002191

Trial Lead
Scott M. Norberg, D.O.

Research

Dr. Norberg conducts clinical research to develop T cell therapies for the treatment of patients with cancer and precancerous diseases. This includes conducting clinical trials using genetically engineered T cells to treat patients with advanced human papillomavirus (HPV) malignancies.

Publications

PRGN-2012 gene therapy in adults with recurrent respiratory papillomatosis: a pivotal phase 1/2 clinical trial

Norberg SM, Valdez J, Napier S, Kenyon M, Ferraro E, Wheatley M, Parsons-Wandell L, Doran SL, Lankford A, Sabzevari H, Brough DE, Schlom J, Gulley JL, Allen CT

Lancet Respir Med. 13(4): 318-326, 2025. [ Journal Article ]

Adoptive transfer of membrane-restricted IL-12-TCR T cells promotes antigen spreading and elimination of antigen-negative tumor variants

Zhang L, Norberg SM, Karimipour F, Davies JS, Kuznetsov A, Lassoued W, Burnett D, Homan P, Cam M, Sinkoe A, Xue P, Gulley JL, Hinrichs CS

J Immunother Cancer. 12(11): 2024. [ Journal Article ]

The tumor microenvironment state associates with response to HPV therapeutic vaccination in patients with respiratory papillomatosis

Norberg SM, Bai K, Sievers C, Robbins Y, Friedman J, Yang X, Kenyon M, Ward E, Schlom J, Gulley J, Lankford A, Semnani R, Sabzevari H, Brough DE, Allen CT

Sci Transl Med. 15(719): 2023. [ Journal Article ]

Engineered T cell therapy for viral and non-viral epithelial cancers

Norberg SM, Hinrichs CS

Cancer Cell. 41(1): 58-69, 2023. [ Journal Article ]

TCR-engineered T cells targeting E7 for patients with metastatic HPV-associated epithelial cancers

Nagarsheth NB, Norberg SM, Sinkoe AL, Adhikary S, Meyer TJ, Lack JB, Warner AC, Schweitzer C, Doran SL, Korrapati S, Stevanovic S, Trimble CL, Kanakry JA, Bagheri MH, Ferraro E, Astrow SH, Bot A, Faquin WC, Stroncek D, Gkitsas N, Highfill S, Hinrichs CS.

Nat Med. 2021.

Full-Text Article

[ Journal Article ]

Biography

Associate Research Physician