Brigitte C. Widemann, M.D.

Brigitte C. Widemann, M.D.
Chief
Head, Pharmacology and Experimental Therapeutics Section
Senior Investigator
CCR Deputy Director

Dr. Brigitte Widemann is a pediatric oncologist with the primary interest of developing effective therapies for children and adults with genetic tumor predisposition syndromes, such as neurofibromatosis type 1 (NF1), and rare solid tumors through innovative clinical trial design. Dr. Widemann currently serves as the head of the Pharmacology & Experimental Therapeutics Section and as Chief of NCI’s Pediatric Oncology Branch.
Anticancer drug discovery and development are moving towards a more rational and targeted approach. The application of new molecularly targeted agents to the treatment of childhood cancers and neurofibromatosis type 1 (NF1) is a research objective of the Pharmacology & Experimental Therapeutics Section (PETS). In addition to studying the pharmacology, pharmacokinetics, pharmacodynamics, and toxicities of these novel agents, it is also a goal of the PETS to evaluate novel clinical trial designs and trial endpoints, which may be more applicable for molecularly targeted agents.

Areas of Expertise

1) Pediatric drug development, 2) Clinical trial design, 3) Pharmacology and pharmacokinetics, 4) Rare solid tumors, 5) Genetic tumor predisposition syndromes and Neurofibromatosis Type 1, 6) Natural history studies

Contact Info

Brigitte C. Widemann, M.D.
Center for Cancer Research
National Cancer Institute
Building 10, Room 1-3752
Bethesda, MD 20892
Ph: 240-760-6203
bw42y@nih.gov

Pharmacology and Experimental Therapeutics Section

Anticancer drug discovery and development are moving towards a more rational and targeted approach. The Pharmacology and Experimental Therapeutics Section (PETS) focuses on the clinical development of new agents for the treatment of refractory childhood cancers and genetic tumor predisposition syndromes (GTPS) such as neurofibromatosis type 1 (NF1), neurofibromatosis type 2 (NF2), and hereditary medullary thyroid carcinoma (MTC). This includes preclinical and clinical studies to analyze the pharmacokinetics (PK), pharmacodynamics (PD), toxicity, and activity of novel agents in childhood tumors. By leveraging unique NIH resources, the Section has applied the principles of drug development for refractory cancers to NF1-related tumors. Simultaneous or sequential clinical development of agents with scientific rationale for both refractory cancers and GTPSs (e.g., tipifarnib or sorafenib) has provided special insights by directly comparing toxicities, PK, and PD of new agents, which have been informative for the development of these agents for both populations. Due to the distinct characteristics of GTPSs, the Section has developed new trial designs, methods of image analysis, and trial endpoints, which allow for more meaningful and safe evaluation of novel agents. The PET Section is conducting clinical trials with targeted agents as single and limited institution studies and in collaboration with consortia, for example, the Children’s Oncology Group Phase I/Pilot Consortium, the NF Clinical Trials Consortium, and the sarcoma cooperative group SARC.

The PET Section uses an integrated research program that includes preclinical models to study the pharmacology and applications of new agents in childhood tumors and an active clinical trials program to study the toxicity, activity, pharmacokinetics and pharmacodynamics of these agents in children and young adults. In collaboration with the Pediatric Neuro-Oncology Section, the central nervous system pharmacology of anticancer drugs is also studied because of the high incidence of primary and metastatic central nervous system cancers in children. Clinical trials are developed with an emphasis on new trial designs and endpoints, and are performed as single institution studies or collaboratively with other children's cancer centers or cooperative groups. 

A variety of agents are studied including cytotoxic drugs, molecularly targeted drugs, antiangiogenic agents, and drugs that modulate the therapeutic or toxic effects of anticancer drugs. The PET Section works with the Cancer Therapy Evaluation Program (CTEP) and the pharmaceutical industry to ensure that promising new drugs are studied in children.  Dr. Widemann serves as the NCI Pediatric Oncology Branch (POB) principal investigator of the Children’s Oncology Group Phase I Pilot Consortium and the Department of Defense-sponsored Neurofibromatosis Consortium. She also works with the sarcoma cooperative group SARC. Some of the clinical trials performed through these consortia are thus available to patients referred to the POB for clinical trials.

In addition to the conduct of early clinical trials for children and young adults with refractory cancers, the PET Section has established a program for NF1-related tumor and non-tumor manifestations. Phase I and II trials for NF1-related plexiform neurofibromas, which cannot be easily resected, and for patients with NF1-associated and sporadic malignant peripheral nerve sheath tumors (MPNST) are conducted.  In addition to treatment trials, a longitudinal natural history trial for children and young adults with NF1 is open for enrollment. On this study, individuals with NF1 are followed longitudinally for their tumor and non-tumor manifestations. A better understanding of the natural history of NF1 will be helpful for the development of clinical trial designs and outcome measurements to explore novel and effective treatments for the many tumor and non-tumor manifestations of NF1.

Under direction of Dr. Eva Dombi the PET Section uses novel approaches for image analysis of tumors in patients with NF1. The use of volumetric MRI analysis of plexiform neurofibromas was developed at the Branch and allows for more sensitive measurements of these complex tumors.

Multiple endocrine neoplasia (MEN) types 2A and 2B are rare genetic diseases, which lead to the development of medullary thyroid cancer and pheochromocytoma.  Surgery has been the standard treatment for these cancers and patients can be cured only by thyroidectomy when the tumor is still confined to the thyroid gland. Traditional chemotherapy is not effective.  The PET Section has an active research program in MEN-associated medullary thyroid cancer.  A clinical trial evaluating the targeted agent vandetanib in the treatment of children and young adults with medullary thyroid carcinoma was recently completed and Dr. Widemann serves as an investigator for a Children’s Oncology Group clinical trial evaluating cabozantanib in the treatment of pediatric patients with this disease.  Other efforts in this area include a clinical study following the natural history of the disease in young patients, research aimed at understanding how the cancer develops resistance to drugs like vandetanib, and the ongoing evaluation of novel therapies for medullary thyroid cancer.

Laboratory Support Staff. The PET Section is fortunate to have 3 permanent technical laboratory support staff (Ms. Diane Cole, Mr. Robert Murphy, and Ms. Nalini Jayaprakash) each of whom have provided support to the section for more than 20 years. They provide the expertise to support the quantitative analysis of pharmacokinetic and pharmacodynamic endpoints for non-human primate studies, in vitro studies, and clinical trials. Assays used include plate assays (ELISAs, RIA, functional assays), analysis of heavy metal compounds by atomic absorption spectrometry, and analysis of small molecules by HPLC with a variety of detection methods (UV, fluorescence, electrochemistry, and mass spectrometry).

Clinical Trials Support Staff. The PET Section and POB research nurses (Andrea Baldwin PNP, Joanne Derdak NP, Trish Whitcomb RN, Anne Goodwin RN, Claudia Derse Anthony RN, and Melisssa Amaya RN) have great expertise and have been highly committed to the coordination of early clinical trials for children and young adults with refractory cancers or genetic tumor predisposition syndromes.

For questions regarding PET Section clinical trials, please contact Ms. Cynthia Boyle, RN, at 301-496-0932 or by e-mail: cynthia.boyle@nih.go

 

NIH Scientific Focus Areas:
Clinical Research, Genetics and Genomics
View Dr. Widemann's PubMed Summary.

Selected Recent Publications

  1. Gross AM, Wolters PL, Dombi E, Baldwin A, Whitcomb P, Fisher MJ, Weiss B, Kim A, Bornhorst M, Shah AC, Martin S, Roderick MC, Pichard DC, Carbonell A, Paul SM, Therrien J, Kapustina O, Heisey K, Clapp DW, Zhang C, Peer CJ, Figg WD, Smith M, Glod J, Blakeley JO, Steinberg SM, Venzon DJ, Doyle LA, Widemann BC.
    New Engl J Med. 382(15): 1430-42, 2020. [ Journal Article ]
  2. Widemann BC
    Lancet Oncol. 21(1): 14-15, 2020. [ Journal Article ]
  3. Glod J, Arnaldez FI, Wiener L, Spencer M, Killian JK, Meltzer P, Dombi E, Derse-Anthony C, Derdak J, Srinivasan R, Linehan WM, Miettinen M, Steinberg SM, Helman L, Widemann BC.
    Clin Cancer Res. 25(21): 6302-8, 2019. [ Journal Article ]
  4. Gross AM, Singh G, Akshintala S, Baldwin A, Dombi E, Ukwuani S, Goodwin A, Liewehr DJ, Steinberg SM, Widemann BC.
    Neuro Oncol. 20(12): 1643-51, 2018. [ Journal Article ]
  5. Kraft IL, Akshintala S, Zhu Y, Lei H, Derse-Anthony C, Dombi E, Steinberg SM, Lodish M, Waguespack SG, Kapustina O, Fox E, Balis FM, Merino MJ, Meltzer PS, Glod JW, Shern JF, Widemann BC.
    Clin Cancer Res. 24(4): 753-65, 2018. [ Journal Article ]

Dr. Brigitte Widemann is a pediatric oncologist with the primary interest of developing effective therapies for children and adults with genetic tumor predisposition syndromes, such as neurofibromatosis type 1 (NF1), and rare solid tumors. She began her career in medicine in Germany where she completed her pediatric residency at the University of Cologne. Dr. Widemann then moved to the NIH for a pediatric hematology and oncology fellowship in the Pediatric Oncology Branch of the NCI. She conducted her research in the Pharmacology and Experimental Therapeutics Section (PETS),  where she studied antimetabolites and had a leadership role in the clinical development of glucarpidase, a rescue agent for patients who experience renal failure after administration of high-dose methotrexate.

Dr. Widemann established a comprehensive clinical research program to study the natural history of NF1 and develop meaningful clinical trials for patients with peripheral nerve sheath tumors. After a series of clinical trials, Dr. Widemann’s team led the  phase II registration trial of the MEK inhibitor selumetinib, which resulted in the first ever FDA approval of a medical therapy for NF1 related inoperable plexiform neurofibromas in children with NF1. Dr. Widemann has expanded these efforts to other rare tumors and is a founding member of the NCI Rare Tumor Initiative and a co-leader on the Cancer Moonshot funded My Pediatric and Adult Rare Tumor Network (MyPART).  MyPART aims to engage patients, advocacy groups, researchers and clinicians in the study of rare pediatric and adult tumors with the ultimate goal of developing effective therapies. Dr. Widemann is collaborating extensively with extramural institutions and groups to advance common research goals. This includes the Response Evaluation in Neurofibromatosis and Schwannomatosis International Working Group REiNS, the Children’s Oncology Group and the Pediatric Early Phase Clinical Trials Network (PEP-CTN), the sarcoma cooperative group SARC, The Department of Defense sponsored NF Clinical Trials Consortium (NFCTC) and the Developmental and Hyperactive Ras Tumor (DHART) SPORE. Dr. Widemann currently serves as the  head of the Pharmacology & Experimental Therapeutics Section, as Chief of NCI’s Pediatric Oncology Branch, and as a clinical Deputy Director of the CCR.

Name Position
Srivandana Akshintala MBBS, MPH Special Volunteer
Andrea Baldwin N.P. Nurse Practitioner
Julia Cohen M.D. Clinical Fellow
Jaydira Del Rivero M.D. Assistant Research Physician
Jennifer L. DeSanto R.N. Research Nurse
Eva Dombi, M.D. Biologist
Anne M. Dufek CRNP Nurse Practitioner
Crystal Flowers Contractor
Sarah N. Fuller Postdoctoral Fellow (CRTA)
Andrea M. Gross, M.D. Assistant Research Physician
Kara Heisey Patient Care Coordinator (Contr.)
Susan M. Hughes Administrative Assistant (Contr.)
Maran Ganesh Ilanchezhian Postbaccalaureate Fellow (CRTA)
Souvik Karmakar Ph.D. Postdoctoral Fellow (CRTA)
Sophia R. Khan Special Volunteer
Cindy Lester McCully B.S. Biologist
Robert Murphy B.S. Research Chemist
Haiying Qin Senior Research Assistant
Margarita J. Raygada Ph.D. Geneticist
Abby B. Sandler Ph.D. Special Assistant
Douglas Stewart Ph.D. Adjunct Investigator
Barbara Jane (BJ) Thomas R.N. Research Nurse (Contr.)
Cecilia M. Tibery Contractor
Francesco Tomassoni Ardori Ph.D. Scientist (Contr.)
Christina A. Vivelo Communications Specialist (Contr.)
Patricia (Trish) Whitcomb B.S. Nurse Specialist
Miguel Davon Wolfe Research Associate (Contr.)