Tim F. Greten, M.D.
Tim F. Greten, M.D.
Investigator
Head, Gastrointestinal Malignancy Section

Dr. Greten is an expert in hepatobiliary cancers and liver immunology. His research is focused on better understanding of how non-immune based therapies effect tumor specific immune responses including suppressor mechanisms in patients with hepatobiliary cancers. He is currently studying novel immune based therapies combined with ablative therapies including radiofrequency ablation, transarterial chemoembolization and radiation for the treatment of patients with primary cancers of the liver and pancreas as well as patients with liver metastasis.

Areas of Expertise
1) Immunotherapy 2) Liver Immunology 3) Myeloid derived suppressor cells 4) Gastrointestinal cancer 5) Liver cancer and hepatocellular carcinoma 6) Liver metastasis

Contact Info

Tim F. Greten, M.D.
Center for Cancer Research
National Cancer Institute
Building 10, Room 12N226
Bethesda, MD 20892
301-451-4723
gretentf@mail.nih.gov

Dr. Greten's major research interest has been the effect of tumor development and tumor-specific treatment on immune response in cancer patients. In addition, his group is interested in identification of tumor suppressor mechanisms with a special focus on new pathways to target these inhibitory mechanisms.

His research is currently focused on investigating the role of myeloid derived suppressor cells (MDSC). MDSC occur during acute and chronic inflammation and are potent suppressors of the adaptive and innate immune system. Therefore these cells play an important role in the context of inflammation-related tumor development. Dr. Greten's laboratory is currently investigating the role of MDSC, both in murine models of inflammation and cancer as well as in humans with cancer.

Scientific Focus Areas:
Cancer Biology, Clinical Research, Immunology
  1. Hoechst B, Ormandy LA, Ballmaier M, Lehner F, Krüger C, Manns MP, Greten TF, Korangy F.
    Gastroenterology. 135: 234-43, 2008. [ Journal Article ]
  2. Hoechst B, Voigtlaender T, Ormandy L, Gamrekelashvili J, Zhao F, Wedemeyer H, Lehner F, Manns MP, Greten TF, Korangy F.
    Hepatology. 50: 799-807, 2009. [ Journal Article ]
  3. Hoechst B, Gamrekelashvili J, Manns MP, Greten TF, Korangy F.
    Blood. 117: 6532-41, 2011. [ Journal Article ]
  4. Gamrekelashvili J, Kapanadze T, Han M, Wissing J, Ma C, Jaensch L, Manns MP, Armstrong T, Jaffee E, White AO, Citrin DE, Korangy F, Greten TF.
    J. Clin. Invest. 123: 4755-68, 2013. [ Journal Article ]
  5. Kapanadze T, Gamrekelashvili J, Ma C, Chan C, Zhao F, Hewitt S, Zender L, Kapoor V, Felsher DW, Manns MP, Korangy F, Greten TF.
    J. Hepatol. 59: 1007-13, 2013. [ Journal Article ]

Tim F. Greten, M.D., received his medical training at Christian Albrechts University in Kiel, Germany in 1993. He did his internship in Munich followed by a 3-year postdoctoral fellowship at the Johns Hopkins University (Baltimore, Maryland), in the laboratory of Drew Pardoll and Liz Jaffee, where he initiated his work in the field of tumor immunology. In 1999 Dr. Greten returned to Hannover Medical School, where he finished his training in internal medicine (2003), medical oncology (2004) and gastroenterology (2007). He held an associate professor position in the Department of Gastroenterology, Hepatology and Endocrinology.  In February 2010 Dr. Greten joined CCR's Medical Oncology Branch as head of the Gastrointestinal Malignancy Section.

Dr. Greten has published more than 70 peer-reviewed papers on basic tumor immunology, translational research studies in hepatocellular carcinoma (HCC) as well as on clinical trials in different gastrointestinal malignancies, including HCC. He has also headed the Group for Hepatobiliary Carcinoma from 2006 until 2010 where he has coordinated and directed the German Clinical trial Group (AIO). Currently, Dr. Greten is a member of the NCI Gastrointestinal Malignancy Faculty and Immunology Faculty.

Name Position
Stefanie Carey Patient Care Coordinator (Contr.)
Austin G. Duffy, M.D. Staff Clinician
Tobias Eggert M.D. Postdoctoral Fellow (Visiting)
Mei Elgindi Postbaccalaureate Fellow
Suzanne Fioravanti R.N., B.S.N., O.C.N. Research Nurse Specialist
Miaojun Han Ph.D. Postdoctoral Fellow (Visiting)
Chi Ma Ph.D. Postdoctoral Fellow (Visiting)
Jose Medina Echeverz Ph.D. Postdoctoral Fellow (Visiting)
Oxana Rusher Medical Oncology Fellow
Melissa Walker R.N. Research Nurse Specialist
Andrew Wilson Postbaccalaureate Fellow

Clinical Trials

Research

Dr. Greten's major research interest has been the effect of tumor development and tumor-specific treatment on immune response in cancer patients. In addition, his group is interested in identification of tumor suppressor mechanisms with a special focus on new pathways to target these inhibitory mechanisms.

His research is currently focused on investigating the role of myeloid derived suppressor cells (MDSC). MDSC occur during acute and chronic inflammation and are potent suppressors of the adaptive and innate immune system. Therefore these cells play an important role in the context of inflammation-related tumor development. Dr. Greten's laboratory is currently investigating the role of MDSC, both in murine models of inflammation and cancer as well as in humans with cancer.

Scientific Focus Areas:
Cancer Biology, Clinical Research, Immunology

Publications

  1. Hoechst B, Ormandy LA, Ballmaier M, Lehner F, Krüger C, Manns MP, Greten TF, Korangy F.
    Gastroenterology. 135: 234-43, 2008. [ Journal Article ]
  2. Hoechst B, Voigtlaender T, Ormandy L, Gamrekelashvili J, Zhao F, Wedemeyer H, Lehner F, Manns MP, Greten TF, Korangy F.
    Hepatology. 50: 799-807, 2009. [ Journal Article ]
  3. Hoechst B, Gamrekelashvili J, Manns MP, Greten TF, Korangy F.
    Blood. 117: 6532-41, 2011. [ Journal Article ]
  4. Gamrekelashvili J, Kapanadze T, Han M, Wissing J, Ma C, Jaensch L, Manns MP, Armstrong T, Jaffee E, White AO, Citrin DE, Korangy F, Greten TF.
    J. Clin. Invest. 123: 4755-68, 2013. [ Journal Article ]
  5. Kapanadze T, Gamrekelashvili J, Ma C, Chan C, Zhao F, Hewitt S, Zender L, Kapoor V, Felsher DW, Manns MP, Korangy F, Greten TF.
    J. Hepatol. 59: 1007-13, 2013. [ Journal Article ]

Biography

Tim F. Greten, M.D., received his medical training at Christian Albrechts University in Kiel, Germany in 1993. He did his internship in Munich followed by a 3-year postdoctoral fellowship at the Johns Hopkins University (Baltimore, Maryland), in the laboratory of Drew Pardoll and Liz Jaffee, where he initiated his work in the field of tumor immunology. In 1999 Dr. Greten returned to Hannover Medical School, where he finished his training in internal medicine (2003), medical oncology (2004) and gastroenterology (2007). He held an associate professor position in the Department of Gastroenterology, Hepatology and Endocrinology.  In February 2010 Dr. Greten joined CCR's Medical Oncology Branch as head of the Gastrointestinal Malignancy Section.

Dr. Greten has published more than 70 peer-reviewed papers on basic tumor immunology, translational research studies in hepatocellular carcinoma (HCC) as well as on clinical trials in different gastrointestinal malignancies, including HCC. He has also headed the Group for Hepatobiliary Carcinoma from 2006 until 2010 where he has coordinated and directed the German Clinical trial Group (AIO). Currently, Dr. Greten is a member of the NCI Gastrointestinal Malignancy Faculty and Immunology Faculty.

Team

Name Position
Stefanie Carey Patient Care Coordinator (Contr.)
Austin G. Duffy, M.D. Staff Clinician
Tobias Eggert M.D. Postdoctoral Fellow (Visiting)
Mei Elgindi Postbaccalaureate Fellow
Suzanne Fioravanti R.N., B.S.N., O.C.N. Research Nurse Specialist
Miaojun Han Ph.D. Postdoctoral Fellow (Visiting)
Chi Ma Ph.D. Postdoctoral Fellow (Visiting)
Jose Medina Echeverz Ph.D. Postdoctoral Fellow (Visiting)
Oxana Rusher Medical Oncology Fellow
Melissa Walker R.N. Research Nurse Specialist
Andrew Wilson Postbaccalaureate Fellow

Posters