Steven A. Rosenberg, M.D., Ph.D.
Steven A. Rosenberg, M.D., Ph.D.
Chief
Senior Investigator
Head, Tumor Immunology Section

Center for Cancer Research
National Cancer Institute

Building 10 - Hatfield CRC, Room 3-3940
Bethesda, MD 20892-1201
301-496-4164

Dr. Rosenberg pioneered the development of effective immunotherapies and gene therapies for patients with advanced cancers. His studies of the adoptive transfer of genetically modified lymphocytes have resulted in the regression of metastatic cancer in patients with melanoma, sarcomas and lymphomas.

His current research is aimed at defining the host immune response of patients to their cancers. These studies emphasize the ability of human lymphocytes to recognize unique cancer antigens and the identification of anti-tumor T cell receptors that can be exploited to develop new cell transfer immunotherapies for the treatment of cancer patients.

As Chief, Dr. Rosenberg also oversees the Branch’s extensive clinical program aimed at translating scientific advances into effective immunotherapies for patients with cancer

Areas of Expertise
1) cancer immunotherapy 2) tumor-infiltrating lymphocytes 3) cancer antigens 4) T cell receptors 5) metastatic melanoma 6) gene therapy

Dr. Rosenberg has pioneered the development of immunotherapy that has resulted in the first effective immunotherapies for selected patients with advanced cancer. His studies of cell transfer immunotherapy have resulted in durable complete remissions in patients with metastatic melanoma. He has also pioneered the development of gene therapy and was the first to successfully insert foreign genes into humans. His recent studies of the adoptive transfer of genetically modified lymphocytes has resulted in the regression of metastatic cancer in patients with melanoma, sarcomas and lymphomas.

Scientific Focus Areas:
Cancer Biology, Clinical Research, Immunology
Selected Recent Publications
  1. Tran E, Turcotte S, Gros A, Robbins PF, Lu YC, Dudley ME, Wunderlich JR, Somerville RP, Hogan K, Hinrichs CS, Parkhurst MR, Yang JC, Rosenberg SA.
    Science. 344: 641-5, 2014. [ Journal Article ]
  2. Gros A, Robbins PF, Yao X, Li YF, Turcotte S, Tran E, Wunderlich JR, Mixon A, Farid S, Dudley ME, Hanada K, Almeida JR, Darko S, Douek DC, Yang JC, Rosenberg SA.
    J. Clin. Invest. 124: 2246-59, 2014. [ Journal Article ]
  3. Robbins PF, Lu YC, El-Gamil M, Li YF, Gross C, Gartner J, Lin JC, Teer JK, Cliften P, Tycksen E, Samuels Y, Rosenberg SA
    Nat Med. 19: 747-752, 2013. [ Journal Article ]
  4. Kochenderfer JN, Rosenberg SA
    Nat Rev Clin Oncol. 10: 267-276, 2013. [ Journal Article ]
  5. Rosenberg SA, Yang JC, Sherry RM, Kammula US, Hughes MS, Phan GQ, Citrin DE, Restifo NP, Robbins PF, Wunderlich JR, Morton KE, Laurencot CM, Steinberg SM, White DE, Dudley ME
    Clin Cancer Res. 17: 4550-4557, 2011. [ Journal Article ]

Dr. Rosenberg is Chief of Surgery at the National Cancer Institute in Bethesda, Maryland and a Professor of Surgery at the Uniformed Services University of Health Sciences and the George Washington University School of Medicine and Health Sciences. He received his B.A. and M.D. degrees at Johns Hopkins University and a Ph.D. in Biophysics at Harvard University. After completing his residency training in surgery in 1974 at the Peter Bent Brigham Hospital in Boston, Massachusetts, Dr. Rosenberg became the Chief of Surgery at the NCI, NIH, a position he has held to the present time. Dr. Rosenberg developed the first effective immunotherapies and gene therapies for patients with advanced cancer. His studies of cell transfer immunotherapy have resulted in durable complete remissions in patients with metastatic melanoma. He was the first to successfully insert foreign genes into humans and his recent studies of the adoptive transfer of genetically modified lymphocytes has resulted in the regression of metastatic cancer in patients with melanoma, sarcomas and lymphomas.

Position Number of Positions Contact E-mail Contact Name Contact Phone
Postdoctoral Fellow 2

sar@nih.gov

Steven A. Rosenberg M.D., Ph.D. 301-496-4164
Staff Scientist 1

sar@nih.gov

Steven A. Rosenberg, MD, Ph.D. 301-496-4164
Name Position
Daniel Abate-Daga Ph.D. Postdoctoral Fellow (Visiting)
Mojgan Ahmadzadeh Ph.D. Research Fellow (Contr)
Mack Bell Postdoctoral Fellow (Visiting)
Mini Bharathan Research Fellow
Mary Black Research Biologist
Tracy Campbell Postbaccalaureate Fellow
Cyrille Cohen Research Fellow
David N. Danforth Jr. M.S., M.D. Staff Clinician
Drew Deniger Postdoctoral Fellow (Visiting)
Mary B. Ganges Laboratory Technician (Contr)
Jared Gartner Research Biologist
Alena Gros Ph.D. Postdoctoral Fellow (CRTA)
Ken-ichi Hanada M.D., Ph.D. Staff Scientist
Tangying Lu Research Fellow
Yong-Chen Lu Ph.D. Postdoctoral Fellow (Visiting)
Richard A. Morgan Ph.D. Special Volunteer
Lien T. Ngo Research Biologist
Anna Pasetto Postdoctoral Fellow (Visiting)
Shashankkumar Patel Predoctoral Fellow
Giao Q. Phan M.D., F.A.C.S. Staff Clinician
Todd Prickett Ph.D. Research Fellow
Satyajit Ray Ph.D. Research Biologist
Robert Taylor Ripley M.D. Investigator
Richard M. Sherry M.D. Staff Clinician
Eric Tran Ph.D. Postdoctoral Fellow (Visiting)
Zhiya Yu Research Biologist
Zhili Zheng Research Biologist

Summary

Dr. Rosenberg pioneered the development of effective immunotherapies and gene therapies for patients with advanced cancers. His studies of the adoptive transfer of genetically modified lymphocytes have resulted in the regression of metastatic cancer in patients with melanoma, sarcomas and lymphomas.

His current research is aimed at defining the host immune response of patients to their cancers. These studies emphasize the ability of human lymphocytes to recognize unique cancer antigens and the identification of anti-tumor T cell receptors that can be exploited to develop new cell transfer immunotherapies for the treatment of cancer patients.

As Chief, Dr. Rosenberg also oversees the Branch’s extensive clinical program aimed at translating scientific advances into effective immunotherapies for patients with cancer

Areas of Expertise
1) cancer immunotherapy 2) tumor-infiltrating lymphocytes 3) cancer antigens 4) T cell receptors 5) metastatic melanoma 6) gene therapy

Clinical Trials

Research

Dr. Rosenberg has pioneered the development of immunotherapy that has resulted in the first effective immunotherapies for selected patients with advanced cancer. His studies of cell transfer immunotherapy have resulted in durable complete remissions in patients with metastatic melanoma. He has also pioneered the development of gene therapy and was the first to successfully insert foreign genes into humans. His recent studies of the adoptive transfer of genetically modified lymphocytes has resulted in the regression of metastatic cancer in patients with melanoma, sarcomas and lymphomas.

Scientific Focus Areas:
Cancer Biology, Clinical Research, Immunology

Publications

Selected Recent Publications
  1. Tran E, Turcotte S, Gros A, Robbins PF, Lu YC, Dudley ME, Wunderlich JR, Somerville RP, Hogan K, Hinrichs CS, Parkhurst MR, Yang JC, Rosenberg SA.
    Science. 344: 641-5, 2014. [ Journal Article ]
  2. Gros A, Robbins PF, Yao X, Li YF, Turcotte S, Tran E, Wunderlich JR, Mixon A, Farid S, Dudley ME, Hanada K, Almeida JR, Darko S, Douek DC, Yang JC, Rosenberg SA.
    J. Clin. Invest. 124: 2246-59, 2014. [ Journal Article ]
  3. Robbins PF, Lu YC, El-Gamil M, Li YF, Gross C, Gartner J, Lin JC, Teer JK, Cliften P, Tycksen E, Samuels Y, Rosenberg SA
    Nat Med. 19: 747-752, 2013. [ Journal Article ]
  4. Kochenderfer JN, Rosenberg SA
    Nat Rev Clin Oncol. 10: 267-276, 2013. [ Journal Article ]
  5. Rosenberg SA, Yang JC, Sherry RM, Kammula US, Hughes MS, Phan GQ, Citrin DE, Restifo NP, Robbins PF, Wunderlich JR, Morton KE, Laurencot CM, Steinberg SM, White DE, Dudley ME
    Clin Cancer Res. 17: 4550-4557, 2011. [ Journal Article ]

Biography

Dr. Rosenberg is Chief of Surgery at the National Cancer Institute in Bethesda, Maryland and a Professor of Surgery at the Uniformed Services University of Health Sciences and the George Washington University School of Medicine and Health Sciences. He received his B.A. and M.D. degrees at Johns Hopkins University and a Ph.D. in Biophysics at Harvard University. After completing his residency training in surgery in 1974 at the Peter Bent Brigham Hospital in Boston, Massachusetts, Dr. Rosenberg became the Chief of Surgery at the NCI, NIH, a position he has held to the present time. Dr. Rosenberg developed the first effective immunotherapies and gene therapies for patients with advanced cancer. His studies of cell transfer immunotherapy have resulted in durable complete remissions in patients with metastatic melanoma. He was the first to successfully insert foreign genes into humans and his recent studies of the adoptive transfer of genetically modified lymphocytes has resulted in the regression of metastatic cancer in patients with melanoma, sarcomas and lymphomas.

Positions

Position Number of Positions Contact E-mail Contact Name Contact Phone
Postdoctoral Fellow 2

sar@nih.gov

Steven A. Rosenberg M.D., Ph.D. 301-496-4164
Staff Scientist 1

sar@nih.gov

Steven A. Rosenberg, MD, Ph.D. 301-496-4164

Team

Name Position
Daniel Abate-Daga Ph.D. Postdoctoral Fellow (Visiting)
Mojgan Ahmadzadeh Ph.D. Research Fellow (Contr)
Mack Bell Postdoctoral Fellow (Visiting)
Mini Bharathan Research Fellow
Mary Black Research Biologist
Tracy Campbell Postbaccalaureate Fellow
Cyrille Cohen Research Fellow
David N. Danforth Jr. M.S., M.D. Staff Clinician
Drew Deniger Postdoctoral Fellow (Visiting)
Mary B. Ganges Laboratory Technician (Contr)
Jared Gartner Research Biologist
Alena Gros Ph.D. Postdoctoral Fellow (CRTA)
Ken-ichi Hanada M.D., Ph.D. Staff Scientist
Tangying Lu Research Fellow
Yong-Chen Lu Ph.D. Postdoctoral Fellow (Visiting)
Richard A. Morgan Ph.D. Special Volunteer
Lien T. Ngo Research Biologist
Anna Pasetto Postdoctoral Fellow (Visiting)
Shashankkumar Patel Predoctoral Fellow
Giao Q. Phan M.D., F.A.C.S. Staff Clinician
Todd Prickett Ph.D. Research Fellow
Satyajit Ray Ph.D. Research Biologist
Robert Taylor Ripley M.D. Investigator
Richard M. Sherry M.D. Staff Clinician
Eric Tran Ph.D. Postdoctoral Fellow (Visiting)
Zhiya Yu Research Biologist
Zhili Zheng Research Biologist