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Myeloid Malignancies Program

A trans-NIH multidisciplinary network of researchers and clinicians dedicated to improving early detection, diagnosis, prognosis and development of novel therapeutics for myeloid malignancies.

About

Our Vision

The vision of the NIH Myeloid Malignancies Program is to successfully control, cure and prevent MDS and AML.

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MDS with multi-lineage dysplasia and ringed sideroblasts.
MDS with multi-lineage dysplasia and ringed sideroblasts. Image courtesy of Kathy Calvo, M.D., Ph.D.

The mission of the trans-NIH Myeloid Malignancies Program (MMP) is to develop a comprehensive program aimed at understanding, diagnosing, and treating the heterogeneous collection of myeloid malignancies that arise in children and adults, especially the Myelodysplastic Syndromes (MDS) and secondary or therapy-related Acute Myelogenous Leukemia (AML). Our objective is to establish a trans-NIH clinical research program at the NIH Clinical Center to allow rapid translation of intramural science and the development of novel therapies for patients with MDS and AML.

This program functions as a clinical scientific unit with regular protocol and research progress meetings. It also serves as a focal point for fellows and medical staff education in the practice of translational clinical research in the myeloid malignancies. We aim to utilize new intramural opportunities and initiatives to stimulate translational research in MDS and AML.  

There are more than 10,000 new cases of MDS diagnosed in the U.S. every year. These blood cancers remain difficult to treat due to vast differences in the patient population including great genetic diversity, complicated clinical presentation with similarities to several overlap syndromes, and lack of highly effective and long-lasting treatments. These difficulties inspired the trans-NIH MMP to consolidate expertise and create an interactive and collaborative environment to foster myeloid malignancy care and research through innovative laboratory studies, state-of-the-art research, and promising clinical applications. The overarching goal is to develop novel therapeutic targeting strategies that may significantly alter the natural history of these disorders.


Join Our Email List
To join the Myeloid Malignancy Interest Group email list, please visit the Myeloid Malignancy Interest Group Listserv homepage, then click the “Subscribe or Unsubscribe” link in the right sidebar.

Interns and doctors

Patients & Providers

The NIH Myeloid Malignancies Clinical Program focuses on the rapid translation of science to novel, first-in-disease clinical trials with the aim of developing new science-driven therapy approaches in adult and pediatric patients with myeloid malignancies, especially MDS and secondary AML.

Have questions about Myeloid Malignancies Program clinical trials?

Please contact Christine McGowan via email.

christine.mcgowan@nih.gov

Team

Our team consists of physician-scientists and investigators from multiple institutes within the National Institutes of Health, including NCI, NHLBI, and others.

Leadership

Clinical Director

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Steven Pavletic
Steven Pavletic, MD
(NCI-CCR/ID-CTP)

Steering Committee

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Daniel Larson
Dan Larson, PhD,
co-chair (NCI-CCR/LRBGE)
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Christopher Hourigan
Christopher Hourigan, MD, PhD, co-chair (NHLBI)
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Lea Cunningham
Lea Cunningham, MD (NHGRI, NCI-CCR/ID-CTP)
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Nirali Shah
Nirali Shah, MD, MHSc (NCI-CCR/POB)
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Peter Aplan
Peter Aplan, MD (NCI-CCR/GB)
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Kathy McGraw
Kathy McGraw, PhD (NCI-CCR/LRBGE)
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Katherine Calvo
Katherine Calvo, MD, PhD (NIH/CC/DLM)

Investigators

If you are interested in participating in the trans-NIH Myeloid Malignancies Program, please contact a member of our Leadership.

Kenneth Aldape, MD (NCI-CCR/LP)
Danielle Arnold, MD (NCI-CCR/ID-CTP)
Raul Braylan, MD (NIH/CC)
Alice Chen, MD (NCI/DCTD)
Laura Dillion, PhD (NIH/NHLBI)
James Doroshow, MD (NCI/DCTD)
Grace-Ann Fasaye, ScM (NCI-CCR/GB)
Courtney Fitzhugh, MD (NIH/NHLBI)
Michael Gottesman, MD (NCI-CCR/LCB)
Emma Groarke, MD (NIH/NHLBI)
Dennis Hickstein, MD (NCI-CCR/ID-CTP)
Noa Holtzman, MD (NCI-CCR/ID-CTP)
Christopher Kanakry, MD (NCI-CCR/CIO)
Rosandra Kaplan, MD (NCI-CCR/POB)
Nina Kim, MD (NCI-CCR/ID-CTP)

Core biopsy H & E dysplastic megakaryocites

Our Research Program

We are developing a comprehensive program aimed at understanding and treating myeloid malignancies in children and adults. Our research program has four overarching themes:

  • Pre-clinical models to study MDS biology and therapy
  • Post-transcriptional regulation in MDS/AML
  • Germline predispositions to myeloid malignancies
  • Role of the immune system in control of MDS/AML

Join Our Email List
To join the Myeloid Malignancy Interest Group email list, please visit the Myeloid Malignancy Interest Group Listserv homepage, then click the “Subscribe or Unsubscribe” link in the right sidebar.