Photo of Dr. Alain Mina

Alain Mina, M.D.

  • Center for Cancer Research
  • National Cancer Institute
Immune Deficiency Cellular Therapy Program


My research focuses on identifying signaling pathways that promote leukemogenesis in myeloid malignancies, particularly myelodysplastic syndromes and acute myeloid leukemia as well as developing targeted therapies that could be brought forth into clinical trials. Goal would be to move towards a chemotherapy-free targeted treatment strategy. Other modalities to achieve that goal would be the development of chimeric antigen receptor (CAR) T cells (targeting myeloid cell antigens such as CLL-1, CD123, CD33, etc.), bispecific T cell engagers (BiTE) and immune checkpoint blockade.

    Areas of Expertise

    Cell Therapy
    Stem Cell Transplant
    Myeloid Malignancies
    Myelodysplastic Syndromes (MDS)
    Acute Myelogenous Leukemia (AML)
    Drug Development

    Information for Patients

    Learn more about our clinical trials and the highly specialized care teams that lead them.


    Selected Key Publications

    Inhibitory effects of Tomivosertib in acute myeloid leukemia

    Suarez M, Blyth GT, Mina AA, Kosciuczuk EM, Dolniak B, Dinner S, Altman JK, Eklund EA, Saleiro D, Beauchamp EM, Platanias LC.
    Oncotarget. 12: 955-966, 2021. [ Journal Article ]

    Next-Generation Sequencing in Myeloproliferative Neoplasms: Is This Indicated in All Patients?

    Mina A, Stein B.
    Curr Hematol Malign Reports. 14: 137-144, 2019. [ Journal Article ]

    Inhibitory effects of SEL201 in acute myeloid leukemia

    Kosciuczuk EM, Kar AK, Blyth GT, Fischietti M, Abedin S, Mina AA, Siliezar R, Rzymski T, Brzozka K, Eklund EA, Beauchamp EM, Eckerdt F, Saleiro D, Platanias LC.
    Oncotarget. 10: 7112-7121, 2019. [ Journal Article ]

    Use of hyperbaric oxygen in hematopoietic cell transplantation to aid post-transplant recovery

    Mina A, Aljitawi O.
    J Comp Eff Res. 9: 149-153, 2020. [ Journal Article ]

    Hypoalbuminemia at Day +90 Is Associated with Inferior Nonrelapse Mortality and Overall Survival in Allogeneic Hematopoietic Cell Transplantation Recipients: A Confirmatory Study

    Murthy HS, Sheets K, Kumar A, Nishihori T, Mina A, Chavez JC, Ayala E, Field T, Mathews J, Lock F, Perez L, Betts BC, Khimani F, Miladinovic B, Tsalatsanis A, Ochoa-Bayona JL, Alsina M, Fernandez H, Pidala J, Anasetti C, Kharfan-Dabaja MA.
    Biol Blood Marrow Transplant. 24: 400-405, 2018. [ Journal Article ]