Breadcrumb

Dennis D. Hickstein, M.D.

Dennis D. Hickstein, M.D.

  • Center for Cancer Research
  • National Cancer Institute

RESEARCH SUMMARY

Dr. Hickstein’s laboratory is working on the recently described bone failure syndrome GATA2 deficiency. In particular, the lab is investigating mutations outside of the GATA2 exons in patients with MonoMAC syndrome, mutations associated with myeloid transformation in patients with GATA2 deficiency who have evidence of myeloid progression, and developing new approaches to the treatment of GATA2 deficiency with hematopoietic stem cell transplantation. These studies are carried out in animal models of disease and in human clinical trials.

Areas of Expertise

1) GATA2 deficiency, 2) bone marrow transplantation, 3) myelodysplastic syndrome

Information for Patients

Learn more about our clinical trials and the highly specialized care teams that lead them. 

Publications

Selected Key Publications

Adenosine deaminase deficiency type 2 deficiency masquerading as GATA2 deficiency

Hickstein , Dennis (NIH/NCI) [E]
J Allergy Clinical Immunology. 138(2): 628-630, 2016. [ Journal Article ]

Matched related and unrelated donor hematopoietic stem cell transplantation for DOCK deficiency

Cuellar-Rodriguez J, Freeman AF, Grossman J, Su H, Parta M, Murdock H, Shah N, Bollard C, Kong HH, Moutsopoulos N, Stone K, Gea-Banacloche J, Holland SM, Hickstein DD.
Biol Blood Marrow Transplant. 21(6): 1037-45, 2015. [ Journal Article ]

Transplant for NEMO: this and much, much more

Hickstein DD, Notarangelo L.
Blood. 130(12): 1391-93, 2017. [ Journal Article ]

Haploidentical related donor hematopoietic stem cell transplantation for DOCK8 deficiency using post-transplant cyclophosphamide

Shah NN, Freeman AF, Su H, Cole K, Parta M, Moutsopoulos NM, Baris S, Karakoc-Aydiner E, Hughes TE, Kong HH, Holland SM, Hickstein DD.
Biol Blood Marrow Transplant. 23(6): 980-90, 2017. [ Journal Article ]

Allogeneic Hematopoietic Stem Cell Transplantation for GATA2 Deficiency Using a Busulfan-Based Regimen

Parta M, Shah NN, Baird K, Rafei H, Calvo KR, Hughes T, Cole K, Kenyon M, Schuver BB, Cuellar-Rodriguez J, Zerbe CS, Holland SM, Hickstein DD.
Biol Blood Marrow Transplant. 24(6): 1250-59, 2018. [ Journal Article ]

Job Vacancies

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Team

Research Biologist
Laura Heckendorn
Research Biologist
Robert West, Ph.D.
Nurse Practitioner
Daniele Avila, MSN, CRNP
Patient Liaison (Contr.)
Nina Manaye

Alumni

Dr. Heather Shive
Heather Shive
2010-2014
Staff Scientist
Mizuki Azuma
Mizuki Azuma
2003-2008
Staff Scientist
Hatem Sabaawy
Hatem Sabaawy
2002- 2007
Post-doctoral fellow