Dennis D. Hickstein, M.D.

Dennis D. Hickstein, M.D.

  • Center for Cancer Research
  • National Cancer Institute


Dr. Hickstein’s laboratory is working on the recently described bone failure syndrome GATA2 deficiency. In particular, the lab is investigating mutations outside of the GATA2 exons in patients with MonoMAC syndrome, mutations associated with myeloid transformation in patients with GATA2 deficiency who have evidence of myeloid progression, and developing new approaches to the treatment of GATA2 deficiency with hematopoietic stem cell transplantation. These studies are carried out in animal models of disease and in human clinical trials.

Areas of Expertise

Information for Patients

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Selected Key Publications

Adenosine deaminase deficiency type 2 deficiency masquerading as GATA2 deficiency

Hickstein , Dennis (NIH/NCI) [E]
J Allergy Clinical Immunology. 138(2): 628-630, 2016. [ Journal Article ]

Matched related and unrelated donor hematopoietic stem cell transplantation for DOCK deficiency

Cuellar-Rodriguez J, Freeman AF, Grossman J, Su H, Parta M, Murdock H, Shah N, Bollard C, Kong HH, Moutsopoulos N, Stone K, Gea-Banacloche J, Holland SM, Hickstein DD.
Biol Blood Marrow Transplant. 21(6): 1037-45, 2015. [ Journal Article ]

Transplant for NEMO: this and much, much more

Hickstein DD, Notarangelo L.
Blood. 130(12): 1391-93, 2017. [ Journal Article ]

Haploidentical related donor hematopoietic stem cell transplantation for DOCK8 deficiency using post-transplant cyclophosphamide

Shah NN, Freeman AF, Su H, Cole K, Parta M, Moutsopoulos NM, Baris S, Karakoc-Aydiner E, Hughes TE, Kong HH, Holland SM, Hickstein DD.
Biol Blood Marrow Transplant. 23(6): 980-90, 2017. [ Journal Article ]

Allogeneic Hematopoietic Stem Cell Transplantation for GATA2 Deficiency Using a Busulfan-Based Regimen

Parta M, Shah NN, Baird K, Rafei H, Calvo KR, Hughes T, Cole K, Kenyon M, Schuver BB, Cuellar-Rodriguez J, Zerbe CS, Holland SM, Hickstein DD.
Biol Blood Marrow Transplant. 24(6): 1250-59, 2018. [ Journal Article ]

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Research Biologist
Laura Heckendorn
Research Biologist
Robert West, Ph.D.
Nurse Practitioner
Daniele Avila, MSN, CRNP
Patient Liaison (Contr.)
Nina Manaye


Dr. Heather Shive
Heather Shive
Staff Scientist
Mizuki Azuma
Mizuki Azuma
Staff Scientist
Hatem Sabaawy
Hatem Sabaawy
2002- 2007
Post-doctoral fellow