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Christopher G. Kanakry, M.D.

Christopher G. Kanakry, M.D.

  • Center for Cancer Research
  • National Cancer Institute
Center for Immuno-Oncology

RESEARCH SUMMARY

Dr. Christopher Kanakry pursues basic, translational, and clinical research related to allogeneic hematopoietic cell transplantation. His work largely centers on better understanding and developing the use of post-transplantation cyclophosphamide as graft-versus-host disease prophylaxis. His work spans the generation of new mechanistic immunologic understandings in the laboratory and the direct translation of these understandings to the clinic in early phase clinical studies to improve transplant outcomes for patients with malignant and non-malignant hematologic diseases.

Areas of Expertise

1) allogeneic hematopoietic cell transplantation 2) HLA-haploidentical transplantation 3) graft-versus-host disease (GVHD) 4) post-transplantation cyclophosphamide 5) post-transplant immune reconstitution

Information for Patients

Learn more about our clinical trials and the highly specialized care teams that lead them.

Clinical Trials

Publications

Selected Recent Publications

Post-transplantation cyclophosphamide prevents graft-versus-host disease by inducing alloreactive T cell dysfunction and suppression

Wachsmuth LP, Patterson MT, Eckhaus MA, Venzon DJ, Gress RE, Kanakry CG
J Clin Invest. 130: 2019. [ Journal Article ]

Origin and evolution of the T cell repertoire after posttransplantation cyclophosphamide.

Kanakry CG, Coffey DG, Towlerton AMH, Vulic A, Storer BE, Chou J, Yeung CCS, Gocke CD, Robins HS, O’Donnell PV, Luznik L, Warren EH.
JCI Insight. 1(5): 2016. [ Journal Article ]

Multi-institutional study of post-transplantation cyclophosphamide as single-agent graft-versus-host disease prophylaxis after allogeneic bone marrow transplantation using myeloablative busulfan and fludarabine conditioning

Kanakry CG, O’Donnell PV, Furlong T, de Lima MJ, Wei W, Medeot M, Mielcarek M, Champlin RE, Jones RJ, Thall PF, Andersson BS, Luznik L
J. Clin. Oncology. 32(31): 3497-3505, 2014. [ Journal Article ]

Aldehyde dehydrogenase expression drives human regulatory T cell resistance to posttransplantation cyclophosphamide

Kanakry CG, Ganguly S, Zahurak M, Bolaños-Meade J, Thoburn C, Perkins B, Fuchs EJ, Jones RJ, Hess AD, Luznik L
Sci Transl Med. 5: 211ra157, 1-12, 2013. [ Journal Article ]

Job Vacancies

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Team

Research Nurse (Transplant Coordinator)
Amy Chai, M.S.N., R.N.
Research Fellow
Alessandra de Paula Pohl , Ph.D.
Research Fellow
Rochelle Fletcher, Ph.D.
Special Volunteer
Ashley Hadjis, B.S.
Assistant Research Physician
Mustafa Ali Hyder, M.D.
Special Volunteer
Shanzay Khan
Clinical Fellow
Meredith McAdams, M.D.
Special Volunteer
Michael Patterson
Postdoctoral Fellow (Visiting)
Natalia Schneider Nunes, Ph.D.
Biologist
Xianghong Li, M.S.
Postdoctoral Fellow (Visiting)
Natasha Vinod, Ph.D.