Laboratory of Integrative Cancer Immunology

Chief
Giorgio Trinchieri, M.D.

The Laboratory of Integrative Cancer Immunology (LICM) is a comprehensive research program at the cellular, molecular, biochemical, and genetic level focused on unravelling the metabolic interplay between host immune cells and developing or advancing cancers.  Research in the LICM will address questions relating to the metabolic and biochemical pathways of immune cells and cancers, including their crosstalk at the biochemical level.  In addition, work will encompass immunometabolism in the cellular context by addressing the biology of immune cells including dissection of the numerous complex interactions between the host and developing and/or progressing tumors that form unique, intratumoral or systemic niches (whether anatomical, metabolic or immunological) which ultimately determine disease risk, prognosis, and/or response to conventional or immune-therapeutic efficacy. The Laboratory will also establish collaborative initiatives with other NCI Laboratories with expertise in immunology, chemical biology, natural products, cancer biology, structural biology and mouse cancer genetics modeling to facilitate the development of small molecule- or biologics-based therapeutic applications targeted at modification of immune cell or cancer cell metabolic function toward diminution of progression or to facilitate therapeutic efficacy.

Research Groups

Currently, the LICM is composed of four research groups:

- The ImmunoDynamics Group (Dr. Grégoire Altan-Bonnet) builds quantitative models of the process of cellular decision making in the immune system.

- The HLA Immunogenetics Section (Dr. Mary Carrington) investigates the host genetic effects on human disease. The primary candidates include the HLA class I and II genes located within the human major histocompatibility complex (MHC), because of their central role in the immune response.

- The Inflammatory Cell Dynamics Section (Dr. Romina Goldszmid) studies the underlying mechanisms regulating the functional maturation and dynamics of mononuclear phagocytes (e.g., dendritic cells, monocytes and macrophages) in pathological situations such as cancer and infectious diseases with particular emphasis on the role of the microbiota.

- The Cancer Immunobiology Section (Dr. Giorgio Trinchieri) studies the role of dendritic cells, other innate or adaptive effector cell types, and pro-inflammatory or immunoregulatory cytokines on carcinogenesis and cancer therapy.

Adjunct Investigator

Dr. Li Yang (Head, Tumor Microenvironment Section, Laboratory of Cancer Biology and Genetics, CCR) is investigating the mechanisms of tumor-host interaction underlying tumor initiation, invasion and metastasis, with an emphasis on the contribution of TGF-beta signaling and the COX-2 pathway.

Microbiome and Genetics Core

The LICM also manages one core laboratory, the Microbiome and Genetics Core, supervised by Dr. Colm O'Huigin.


There are no Open Positions at this time. Check back again later, or take a look at CCR's Careers page.


About

The Laboratory of Integrative Cancer Immunology (LICM) is a comprehensive research program at the cellular, molecular, biochemical, and genetic level focused on unravelling the metabolic interplay between host immune cells and developing or advancing cancers.  Research in the LICM will address questions relating to the metabolic and biochemical pathways of immune cells and cancers, including their crosstalk at the biochemical level.  In addition, work will encompass immunometabolism in the cellular context by addressing the biology of immune cells including dissection of the numerous complex interactions between the host and developing and/or progressing tumors that form unique, intratumoral or systemic niches (whether anatomical, metabolic or immunological) which ultimately determine disease risk, prognosis, and/or response to conventional or immune-therapeutic efficacy. The Laboratory will also establish collaborative initiatives with other NCI Laboratories with expertise in immunology, chemical biology, natural products, cancer biology, structural biology and mouse cancer genetics modeling to facilitate the development of small molecule- or biologics-based therapeutic applications targeted at modification of immune cell or cancer cell metabolic function toward diminution of progression or to facilitate therapeutic efficacy.

Research Groups

Currently, the LICM is composed of four research groups:

- The ImmunoDynamics Group (Dr. Grégoire Altan-Bonnet) builds quantitative models of the process of cellular decision making in the immune system.

- The HLA Immunogenetics Section (Dr. Mary Carrington) investigates the host genetic effects on human disease. The primary candidates include the HLA class I and II genes located within the human major histocompatibility complex (MHC), because of their central role in the immune response.

- The Inflammatory Cell Dynamics Section (Dr. Romina Goldszmid) studies the underlying mechanisms regulating the functional maturation and dynamics of mononuclear phagocytes (e.g., dendritic cells, monocytes and macrophages) in pathological situations such as cancer and infectious diseases with particular emphasis on the role of the microbiota.

- The Cancer Immunobiology Section (Dr. Giorgio Trinchieri) studies the role of dendritic cells, other innate or adaptive effector cell types, and pro-inflammatory or immunoregulatory cytokines on carcinogenesis and cancer therapy.

Adjunct Investigator

Dr. Li Yang (Head, Tumor Microenvironment Section, Laboratory of Cancer Biology and Genetics, CCR) is investigating the mechanisms of tumor-host interaction underlying tumor initiation, invasion and metastasis, with an emphasis on the contribution of TGF-beta signaling and the COX-2 pathway.

Microbiome and Genetics Core

The LICM also manages one core laboratory, the Microbiome and Genetics Core, supervised by Dr. Colm O'Huigin.

PI & Key Staff

Positions


There are no Open Positions at this time. Check back again later, or take a look at CCR's Careers page.


Contact Info

Laboratory of Integrative Cancer Immunology
Center for Cancer Research
National Cancer Institute
Building 37, Room 4146A
Bethesda, MD 20892
Ph: 240-760-6641
Administrative Assistant (Contr.)
240-760-6641
Technical Lab Manager
240-760-6891