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Headshot of Masaki Terabe

Masaki Terabe, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Neuro-Oncology Branch

RESEARCH SUMMARY

Dr. Terabe is a trained immunologist who heads the Basic Immunology Research Program at the Neuro-Oncology Branch (NOB). He seeks to understand the mechanisms of immune regulation in cancer patients. He hopes to elucidate what drives the immune system to fail to eliminate a tumor—and use those findings to therapeutically trigger the immune system to act more effectively against the tumor (an approach called immunotherapy). His research currently focuses on natural killer T (NKT) cells, a lesser-known component of the immune system with the response rate of the innate immune system but the antigen specificity of the adaptive immune system. They are unique cells that can be recruited to attack tumors and/or help other immune cells destroy malignant cells. Dr. Terabe hopes to translate his knowledge on NKT cells to new cancer treatments that can help patients combat brain tumors more effectively.

Explore the NOB's Research Programs >

Areas of Expertise

Tumor Immunology
Glioblastoma
Natural Killer T-Cells (NKTs)

Publications

Selected Recent Publications

Targeting the CD47/thrombospondin-1 signaling axis regulates immune cell bioenergetics in the tumor microenvironment to potentiate antitumor immune response

Stirling ER, Terabe M, Wilson AS, Kooshki M, Yamaleyeva LM, Alexander-Miller MA, Zhang W, Miller LD, Triozzi PL, Soto-Pantoja DR
Journal for ImmunoTherapy of Cancer. 10(11): e004712, 2022. [ Journal Article ]

MAIT cells and MR1 play an immunosuppressive role in glioblastoma through the induction of neutrophils and MDSCs

Hana T, Terabe M
bioRxiv. 2022.
Full-Text Article
[ Journal Article ]

Mouse nEoanTigen pRedictOr pipeline (METRO)

Kuhn S, Sevilla S, Steffke E, Terabe M, Koparde V, Hana T
GitHub. 2022.
Full-Text Article

The Role of NKT Cells in Glioblastoma

Brettschneider EES, Terabe M
Cells. 10(7): 1641, 2021. [ Journal Article ]

Unique challenges for glioblastoma immunotherapy-discussions across neuro-oncology and non-neuro-oncology experts in cancer immunology. Meeting Report from the 2019 SNO Immuno-Oncology Think Tank.

Chuntova P, Chow F, Watchmaker PB, Galvez M, Heimberger AB, Newell EW, Diaz A, DePinho RA, Li MO, Wherry EJ, Mitchell D, Terabe M, Wainwright DA, Berzofsky JA, Herold-Mende C, Heath JR, Lim M, Margolin KA, Chiocca EA, Kasahara N, Ellingson BM, Brown CE, Chen Y, Fecci PE, Reardon DA, Dunn GP, Liau LM, Costello JF, Wick W, Cloughesy T, Timmer WC, Wen PY, Prins RM, Platten M, Okada H
Neuro-Oncology. 23(3): 356–375, 2021. [ Journal Article ]

Job Vacancies

There are no open positions at this time. Check back again later, or take a look at CCR's Careers page.

Team

Visiting Fellow
Nargis Malik, Ph.D.
Visiting Fellow
Seketoulie Keretsu, Ph.D.
Biologist
Hye Kyung Kim, M.D.
Postbaccalaureate Fellow (IRTA/CRTA)
Morgan Coombs
Postbaccalaureate Fellow (IRTA/CRTA)
Laila Latifi

News

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Hands in lab gloves looking at a tube in an ice bucket


Immunology and the Brain: Scientific Discoveries Needs to Improve Patient Outcomes

February 9, 2022

As the lead of the Basic Immunology Research Program, Dr. Terabe investigates the functions of T cells in brain and spine cancers, in order to glean a better understanding of glioblastoma immunobiology. Read more >

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Student working at a computer


2021 Summer Internship Program

The NOB welcomed six summer interns for the summer 2021 cohort who were able to observe and engage with clinical and laboratory professionals that lead clinical, translational, and basic research. Read more >

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Dr. Masaki Terabe and Dr. Vibhuti Joshi in lab


Celebrating National Mentoring Month

January 31, 2020

We celebrate our impactful mentors in the Neuro-Oncology Branch for National Mentoring Month. Our postdoctoral fellows share their love for science and how their mentors have made their experience at NIH more rewarding. Read more >