Dr. Mary Carrington

Mary N. Carrington, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Laboratory of Integrative Cancer Immunology


Dr. Carrington is a senior principal scientist at the Frederick National Laboratory for Cancer Research and head of the HLA Immunogenetics Section in the Laboratory of Integrative Cancer Immunology Program.  Her group studies the influence of genetic variation at loci encoding the human leukocyte antigen (HLA), killer cell immunoglobulin-like receptors (KIR), and other immune-related molecules on risk of and outcomes to infection, cancer, autoimmunity, and maternal-fetal disease. Recent studies have focused on identification of HLA allele-specific properties that affect their function beyond peptide binding specificity, such as differential gene expression, dependence on proteins of the antigen processing pathway, and interactions with specific KIR allotypes.  Once values are assigned to these allele-specific attributes, they are then assessed for their impact on disease outcome.

Areas of Expertise

Genetic Epidemiology
Human Leukocyte Antigens (HLA)
Killer Cell Immunoglobulin-Like Receptors (KIR)


Selected Recent Publications

HLA class I signal peptide polymorphism determines the level of CD94/NKG2-HLA-E-mediated regulation of effector cell responses.

Lin Z, Bashirova AA, Viard M, Garner L, Quastel M, Beiersdorfer M, Kasprzak WK, Akdag M, Yuki Y, Ojeda P, Das S, Andresson T, Naranbhai V, Horowitz A, McMichael AJ, Hoelzemer A, Gillespie GM, Garcia-Beltran WF, Carrington M.
Nat. Immunol.. 24/7: 1087-1097, 2023.
Full-Text Article
[ Journal Article ]

Genetic variation that determines TAPBP expression levels associates with the course of malaria in an HLA allotype-dependent manner

Walker-Sperling, V., Digitale, J.C., Viard, M., Martin, M.P., Bashirova, A., Yuki, Y., Ramsuran, V., Kulkarni, S., Naranbhai, V., Li, H., Anderson, S.K., Yum, L., Clifford, R., Kibuuka, H., Ake, J., Thomas, R., Rowland-Jones, S., Rek, J., Arinaitwe, E., Kamya, M., Rodriguez-Barraquer, I., Feeney, M.E., and Carrington, M
Proc. Natl. Acad. Sci. USA. 119: 2022. [ Journal Article ]

HLA-A*03 and response to immune checkpoint blockade in cancer: an epidemiological biomarker study

2Naranbhai, V., Viard, M., Dean, M., Groha, S., Braun, D.A., Labaki, C., Shukla, S.A., Yuki, Y., Shah, P., Chin, K., Wind-Rotolo, M., Mu, X.J., Robbins, P.B., Gusev, A., Choueiri, T.K., Gulley, J.L., and Carrington, M
Lancet Oncol.. 23: 172-184, 2022. [ Journal Article ]

HLA tapasin independence: broader peptide repertoire and HIV control

Bashirova, A.A., Viard, M., Naranbhai, V., Grifoni, A., Garcia-Beltran, W., Akdag, M., Yuki, Y., Gao, X., O’hUigin, C., Raghavan, M., Wolinsky, S., Bream, J.H., Duggal, P., Martinson, J., Michael, N.L., Kirk, G.D., Buchbinder, S.P., Haas, D., Goedert, J.J., Deeks, S.G., Fellay, J., Walker, B., Goulder, P, Cresswell, P., Elliott, T., Sette, A., Carlson, J. and Carrington, M
Proc. Natl. Acad. Sci.. 117: 28232-28238, 2020. [ Journal Article ]

The Role of HLA-DP Expression in Graft-Versus-Host Disease After Unrelated Donor Transplantation

Petersdorf, E.W., Stevenson, P., Bengtsson, M., De Santis, D., Dubois, V., Fleischhauer, K., Gooley, T., Horowitz, M., Madrigal, J.A., Malkki, M., McKallor, C., Morishima, Y., Oudshoorn, M., Spellman, S.R., Villard, J., Stevenson, M.S., Carrington, M.
J. Clin. Oncol.. 28: 2712-2718, 2020. [ Journal Article ]

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Research Associate I (Contr.)
Marjan Akdag, M.S.
Scientist II (Contr.)
Arman Bashirova, Ph.D.
Special Volunteer
Xiao-jiang Gao, Ph.D.
Guest Researcher (Contr.)
Zhansong Lin, Ph.D.
Research Technician (Contr.)
Yeon-Hwa Park, B.S.
Research Associate II (Contr.)
Yuko Yuki, D.D.M.
Guest Researcher
Roxana Moslehi, Ph.D.
Post-Baccalaureate Fellow
Cian Callahan, BS


Renowned FNL scientist joins late father-in-law and world leaders as member of American Academy of Arts and Sciences

Earlier this year, Dr. Mary Carrington was elected to the prestigious American Academy of Arts and Sciences. She will be officially inducted sometime in 2023.

Understanding the Foundations of Immune Defenses

Dr. Mary Carrington elected to the American Academy of Arts and Sciences for Insights into Immune System Variations.

Oyez, Oyez, Oyez! Saunders PM, Brooks AG, Rossjohn J.Nat Immunol. 2023 Jul;24(7):1052-1053. doi: 10.1038/s41590-023-01541-x.PMID: 37308666