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Mary N. Carrington, Ph.D.

Mary N. Carrington, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Laboratory of Integrative Cancer Immunology

RESEARCH SUMMARY

Dr. Carrington is a Senior Principal Scientist within the Frederick National Laboratory and head of the HLA Immunogenetics Section in the Laboratory of Integrative Cancer Immunology. Dr. Carrington’s group studies the influence of immunogenetic variation on risk of human disease, outcome to therapeutic treatment, and vaccination. These studies include elucidation of the functional basis for the genetic associations identified.

Areas of Expertise

1) immunogenetics 2) genetic epidemiology 3) HIV/AIDS 4) human leukocyte antigens (HLA) 5) killer cell immunoglobulin-like receptors (KIR)

Publications

Selected Recent Publications

Killer cell immunoglobulin-like receptor 3DL1 variation modifies HLA-B*57 protection against HIV-1

Martin, M.P., Naranbhani, V., Shea, P.R., Qi, Y., Ramsuran, V., Vince, N., Gao, X., Thomas, R., Brumme, Z.L., Carlson, J.M., Wolinsky, S. Goedert, J.J. Walker, B., Segal, F.P., Deeks, S., Haas,D., Migueles, S., Conners, M., Michael, N., Fellav, J., Price, D.A., Lafont, B.A., Pymm, P., Saunders, P.M., Widjaia, J., Wong, S.C., Vivian, J.P., Rossiohn, J., Brooks, A.G. and Carrington, M.
J. Clin. Invest.. 128: 1903-1912, 2018. [ Journal Article ]

Elevated HLA-A expression impairs HIV control through inhibition of NKG2A expressing cells

Ramsuran, V., Naranbhai, V., Horowitz, A., Qi, Y., Martin, M.P., Yuki, Y., Gao, X., Walker-Sperling, V., DelPrete, G.Q., Schneider, D.K., Lifson, J.D., Fellay, J., Deeks, S.G., Martin, J.N., Goedert, J.J., Wolinsky, S.M., Michael, N.L., Kirk, G.D., Buchbinder, S., Haas, D., Ndung'u, T., Goulder, P., Parham, P., Walker, B.D., Carlson, J.M. and Carrington, M.
Science. 359: 86-90, 2018. [ Journal Article ]

Posttranscriptional regulation of HLA-A protein expression by alternative polyadenylation signals involving the RNA-binding protein syncrip

Kulkarni, S., Ramsuran, V., Rucevic, Singh, S., Lied A., Kulkarni, V., O'hUigin, C., Le Gail, S. and Carrington, M.
J. Immunol.. 199: 3892-3899, 2017. [ Journal Article ]

HIV-1 Vpu mediates HLA-C downregulation.

Apps, R., Del Prete, G.Q., Chatterjee, P., Lara, A., Brumme, Z.L., Brock,an, M.A., Neil, S., Pickering, S., Schneider, D.K., Piechocka-Trocha, A., Walker, B.D., Thomas, R., Shaw, G.M., Hahn, B.H., Keele, B.F., Lifson, J.D. and Carrington, M.
Cell Host Microbe. 19: 686-695, 2016. [ Journal Article ]

Sequence and phylogenetic analysis of the untranslated promoter regions for HLA class I genes

Ramsuran, V., Hernandez-Sanchez, P.G., O'hUigin, C., Sharma, G., Spence, N., Augusto, D.G., Gao, X., Garcia-Sepulveda, C.A., Kaur, G., Mehra, N.K. and Carrington, M.
J. Immunol.. 198: 2320-2329, 2017. [ Journal Article ]

Job Vacancies

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Team

Research Associate I (Contr.)
Marjan Akdag
Scientist I (Contr.)
Arman Amangeldiyevna Bashirova, Ph.D.
Senior Computational Scientist (Contr.)
Eckart Bindewald, Ph.D.
Special Volunteer
Xiao-jiang Gao, Ph.D.
Guest Researcher (Contr.)
Zhansong Lin, Ph.D.
Guest Researcher (Contr.)
Yeon-Hwa Park, Ph.D.
Guest Researcher (Contr.)
Victoria Walker-Sperling
Research Associate II (Contr.)
Yuko Yuki, D.D.M.
Postdoctoral Fellow (Visiting)
Wanjing Zheng, Ph.D.