Romina Goldszmid, Ph.D.

Romina Goldszmid, Ph.D.
Stadtman Investigator

Dr. Goldszmid has a long standing interest in understanding the mechanisms governing the development, functional maturation and dynamics of the mononuclear phagocyte cellular network [e.g. dendritic cells, monocytes and macrophages] that plays an instrumental role in host defense. In particular, her research focuses on linking the microbiome, mononuclear phagocyte development, and cancer and infectious diseases with the ultimate goal of identifying new potential therapeutic interventions to improve cancer treatment.

Areas of Expertise

1) mononuclear phagocytes (dendritic cells, macrophages and monocytes), 2) inflammation, 3) tumor immunology, 4) Toxoplasma gondii, 5) microbiota, 6) innate immunity

Contact Info

Romina Goldszmid, Ph.D.
Center for Cancer Research
National Cancer Institute
Building 37, Room 4134C
Bethesda, MD 20892
Ph: 240-760-6897

Our laboratory aims to understand the underlying mechanisms controlling mononuclear phagocyte (MP) function in pathological situations such as during tumor development or the encounter with an invading pathogen.

The MP cellular network comprises macrophages, monocytes and dendritic cells. These myeloid cells originate during embryonic development or derive from committed precursors in the bone marrow and populate most lymphoid and non-lymphoid tissues. Distributed throughout the body, MPs initiate innate and adaptive immunity against pathogens and tumors, participate in the resolution of inflammation and contribute to tissue integrity. They are also major components of the tumor microenvironment affecting immune evasion, tumor progression, tissue remodeling, angiogenesis and metastasis formation. Individual MP populations control inflammatory settings or stages of inflammation using distinct mechanisms, however, the individual contribution of these distinct cell subsets to the induction and resolution of immunity against invading pathogens, or to anti-tumor responses or immune evasion remains largely unknown.

The focus of our laboratory is to understand what is the relative contribution of the distinct MP populations and what are the critical signals that regulate their development and functional dynamics. We perform comparative studies using cancer and infection models to shed light on the nature of the environmental cues that in pathological situations regulate the differentiation and maturation of individual MP populations. We are particularly interested in the role of the microbiota: combining cellular and molecular approaches together with in vivo studies using germ-free animals we study the effect of commensals on myeloid cell function and their impact on the response to cancer therapy or to the invading pathogen.

Targeting the MP cellular network may be a powerful approach to manipulate the outcome of immune responses; therefore a better understanding of their regulation and functional organization may lead to rational novel therapeutic approaches.


NIH Scientific Focus Areas:
Cancer Biology, Cell Biology, Immunology, Microbiology and Infectious Diseases
View Dr. Goldszmid's PubMed Summary

Selected Recent Publications

  1. Pérez-Guijarro E, Yang HH, Araya RE, El Meskini R, Michael HT, Vodnala SK, Marie KL, Smith C, Chin S, Lam KC, Thorkelsson A, Iacovelli AJ, Kulaga A, Fon A, Michalowski AM, Hugo W, Lo RS, Restifo NP, Sharan SK, Van Dyke T, Goldszmid RS, Weaver Ohler Z, Lee MP, Day CP, Merlino G
    Nat Med. [Epub ahead of print], 2020. [ Journal Article ]
  2. Araya RE, Goldszmid RS
    Cancer Cell. 31(2): 161-3, 2017. [ Journal Article ]
  3. Araya RE, Goldszmid RS
    Immunity. 45(4): 714-16, 2016. [ Journal Article ]
  4. Goldszmid RS, Dzutsev A, Viaud S, Zitvogel L, Restifo NP, Trinchieri G.
    Cancer Immunol Res. 3(2): 103-9, 2015. [ Journal Article ]
  5. Goldszmid RS, Dzutsev A, and Trinchieri G.
    Cell Host Microbe. 15(3): 295-305, 2014. [ Journal Article ]

Dr. Romina Goldszmid received her Ph.D. working on dendritic cell-based vaccines for melanoma immunotherapy from the University of Buenos Aires, Argentina, part of which was performed as a visiting scholar in the laboratory of Dr. Ralph Steinman at the Rockefeller University. She then did her postdoctoral training in infectious disease immunology with Dr. Alan Sher in the Laboratory of Parasitic Diseases (LPD) at the National Institute of Allergy and Infectious Diseases (NIAID), NIH. Dr. Goldszmid then returned to tumor immunology, joining Dr. Giorgio Trinchieri's laboratory at CCR, NCI, as a Staff Scientist. She is now an NIH Earl Stadtman Investigator in the Laboratory of Integrative Cancer Immunology and an Adjunct Investigator in LPD, NIAID.

Name Position
Romina Araya Ph.D. Postdoctoral Fellow (Visiting)
Quanyi Chen Biologist (Contr.)
Khiem Lam B.S. Predoctoral Fellow (Graduate Student)
Amelie Lopes Ph.D. Postdoctoral Fellow (Visiting)