Remy  Bosselut, M.D., Ph.D.

Remy Bosselut, M.D., Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Laboratory of Immune Cell Biology


Our lab's focus is on the transcriptional control of CD4+ T cell development and function. We are specifically interested in the transcriptomic programs controlling the emergence of CD4+ lineage in the thymus and in the transcriptional control of CD4+ T cell responses to pathogens and tumors.

Areas of Expertise

T Lymphocyte
T Cell Development
T Cell Effector Differentiation


Selected Recent Publications

NuRD complex recruitment to Thpok mediates CD4+ T cell lineage differentiation.

Gao Y, Zamisch M, Vacchio M, Chopp L, Ciucci T, Paine EL, Lyons GC, Nie J,
Xiao Q, Zvezdova E, Love PE, Vinson CR, Jenkins LM, Bosselut R.
Sci Immunol. 7(72): 5917, 2022. [ Journal Article ]

The transcription factor LRF promotes integrin β7 expression by and gut homing of CD8αα+ intraepithelial lymphocyte precursors.

Nie J, Carpenter AC, Chopp LB, Chen T, Balmaceno-Criss M, Ciucci T, Xiao Q,
Kelly MC, McGavern DB, Belkaid Y, Bosselut R.
Nat Immunol.. 23(4): 594-604, 2022. [ Journal Article ]

An Integrated Epigenomic and Transcriptomic Map of Mouse and Human αβ T Cell Development.

Chopp LB, Gopalan V, Ciucci T, Ruchinskas A, Rae Z, Lagarde M, Gao Y, Li C,
Bosticardo M, Pala F, Livak F, Kelly MC, Hannenhalli S, Bosselut R.
Immunity. 53(6): 1182-1201, 2020. [ Journal Article ]

A Thpok-Directed Transcriptional Circuitry Promotes Bcl6 and Maf Expression to Orchestrate T Follicular Helper Differentiation.

Vacchio MS, Ciucci T, Gao Y, Watanabe M, Balmaceno-Criss M, McGinty MT, Huang
A, Xiao Q, McConkey C, Zhao Y, Shetty J, Tran B, Pepper M, Vahedi G, Jenkins MK,
McGavern DB, Bosselut R.
Immunity . 51(3): 465-478, 2019. [ Journal Article ]

The Emergence and Functional Fitness of Memory CD4+ T Cells Require the Transcription Factor Thpok.

Ciucci T, Vacchio MS, Gao Y, Tomassoni Ardori F, Candia J, Mehta M, Zhao Y,
Tran B, Pepper M, Tessarollo L, McGavern DB, Bosselut R.
Immunity. 50(1): 91-105, 2018. [ Journal Article ]

Job Vacancies

We have no open positions in our group at this time, please check back later.

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Postdoctoral Fellow (Visiting)
Jia Nie, Ph.D.
Staff Scientist
Melanie Vacchio, Ph.D.
Postdoctoral Fellow (Visiting)
Wenjuan Wang, Ph.D.
Research Biologist
Qi Xiao
Visiting Fellow
Alex Clark, Ph.D
Pre-doctoral IRTA
Shil Patel
Clinical Fellow
Sushant Puri, M.D.
Post-Baccalaureate Fellow
Kaitlyn Twadell, B.S.


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