Breadcrumb

Remy  Bosselut, M.D., Ph.D.

Remy Bosselut, M.D., Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Laboratory of Immune Cell Biology

RESEARCH SUMMARY

Our lab's focus is on the transcriptional control of CD4+ T cell development and function. We are specifically interested in the transcriptomic programs controlling the emergence of CD4+ lineage in the thymus and in the transcriptional control of CD4+ T cell responses to pathogens and tumors.

Areas of Expertise

1) T lymphocyte 2) T cell development 3) T cell effector differentiation 4) transcription 5) chromatin

Publications

Selected Recent Publications

The Emergence and Functional Fitness of Memory CD4(+) T Cells Require the Transcription Factor Thpok

Ciucci T, Vacchio MS, Gao Y, Tomassoni Ardori F, Candia J, Mehta M, Zhao Y, Tran B, Pepper M, Tessarollo L, McGavern DB, and Bosselut R.
Immunity. 50: 91-105.e4, 2019. [ Journal Article ]

A STAT3-dependent transcriptional circuitry inhibits cytotoxic gene expression in T cells

Ciucci T, Vacchio MS, Bosselut R.
Proc Natl Acad Sci U S A. 114: 13236-13241, 2017. [ Journal Article ]

Control of Regulatory T Cell Differentiation by the Transcription Factors Thpok and LRF

Carpenter AC, Wohlfert E, Chopp LB, Vacchio MS, Nie J, Zhao Y, Shetty J, Xiao Q, Deng C, Tran B, Cam M, Gaida MM, Belkaid Y, and Bosselut R.
J Immunol. 199: 1716-1728, 2017. [ Journal Article ]

How T Cells Recycle the CD4+-CD8+ Lineage Commitment Transcriptional Circuitry To Control Their Function

Vacchio MS, and Bosselut R.
J Immunol. 196: 4848-56, 2016. [ Journal Article ]

A ThPOK-LRF transcriptional node maintains the integrity and effector potential of post-thymic CD4+ T cells

Vacchio MS, Wang L, Bouladoux N, Carpenter AC, Xiong Y, Williams LC, Wohlfert E, Song KD, Belkaid Y, Love PE, Bosselut R.
Nat Immunol. 15: 947-56, 2014.

Job Vacancies

There are no open positions at this time. Check back again later, or take a look at CCR's Careers page.

Team

Postbaccalaureate Fellow (CRTA)
Mariah Balmaceno-Criss, BSc.
Predoctoral Fellow (Graduate Student)
Laura Chopp, B.S.
Scientist (Contr.)
Thomas Ciucci, Ph.D.
Predoctoral Fellow (Graduate Student)
Nicholas Franzese
Postdoctoral Fellow (Visiting)
Yayi Gao, Ph.D.
Postdoctoral Fellow (Visiting)
Jia Nie, Ph.D.
Senior Research Assistant
Melanie Vacchio, Ph.D.
Postdoctoral Fellow (Visiting)
Wenjuan Wang, Ph.D.
Research Biologist
Qi Xiao