Grégoire Altan-Bonnet, Ph.D.

Grégoire Altan-Bonnet, Ph.D.
Senior Investigator
Head, ImmunoDynamics Group

I have been trained in Statistical Physics and nonlinear dynamics (PhD) and in Immunology (post-doctoral studies). My field of expertise is Systems Immunology: the ImmunoDynamics group I am heading has been developing experimentally validated quantitative models of different aspects of the immune system. In particular, we have addressed the interplay between the robustness and variability of self/non-self discrimination in the immune system. We are also focused on developing quantitative models of lymphocyte-lymphocyte communications via cytokine. Our current projects focus on the multicellular coordination of immune responses against tumors and pathogenic infections. We are particularly interested in developing quantitative models of the integration of signal transduction, gene regulation, cytokine communications, cell differentiation, and proliferation/death across multiple spatio-temporal scales. Our long-term goal is to help in the development of tailored immunotherapies (e.g. against tumors).

Areas of Expertise

1) immunology, 2) systems biology, 3) computational modeling, 4) biological physics

Contact Info

Grégoire Altan-Bonnet, Ph.D.
Center for Cancer Research
National Cancer Institute
Building 37, Room 4134
Bethesda, MD 20892
Ph: 240-760-6888

We are interested in developing actionable models of the immune response to design and optimize new immunotherapies. Our premise is that the immune system is a self-organized collection of cells, whose individual activation must be harnessed, tuned, and coaxed at the population level. We rely on new quantitative methods (e.g., single-cell phosphoprofiling by FACS and CyTOF) and computational modeling to identify key limiting steps controlling the balance between response and tolerance in the immune system. 

Our computational models are strongly interfaced with our experimental efforts. We model immunological events explicitly, starting from biochemical events (e.g., ligand/receptor interactions) to cellular (signal transduction and gene regulation) to population dynamics. Such integration of multiple spatial- and time-scales is leading to a better understanding of the dynamics of immune responses, and is opening new opportunities for external manipulation and immunotherapies. Our projects go from conceptual and fundamental aspects of the immune system, to very practical applications in the pre-clinical context (profiling of tumors, manipulation of immune responses against tumors).

NIH Scientific Focus Areas:
Biomedical Engineering and Biophysics, Cancer Biology, Immunology, Systems Biology
  1. Oyler-Yaniv A, Oyler-Yaniv J, Whitlock BM, Liu Z, Germain RN, Huse M, Altan-Bonnet G, Krichevsky O.
    Immunity. 48(4): 609-620, 2017. [ Journal Article ]
  2. Altan-Bonnet G, Mukherjee R.
    Nat Rev Immunol. 19(4): 205-217, 2019. [ Journal Article ]
  3. Quantitative immunology for physicists.
    G Altan-Bonnet, T Mora & A Walczak
    Physics Report. 849: 1-83, 2020. [ Journal Article ]
  4. S Ghosh, TA Dellibovi-Ragheb, A Kerviel, E Pak, Q Qiu, M Fisherq, PM Takvorian, C Bleck, VW Hsu, AR Fehr, S Perlman, SR Achar , MR Straus, GR Whittaker, CAM de Haan, J Kehrl, G Altan-Bonnet & N Altan-Bonnet
    Cell. 183(6): Elsevier 1520-1535, 2020. [ Journal Article ]
  5. S Krishna, FJ Lowery, AR Copeland, E Bahadiroglu, R Mukherjee, L Jia, JT Anibal, A Sachs, SO Adebola, D Gurusamy, Z Yu, V Hill, JJ Gartner, YF Li, M Parkhurst, B Paria, P Kvistborg, MC Kelly, SL Goff, G Altan-Bonnet, PF Robbins & SA Rosenberg
    Science. 370(6522): 1328-1334, 2020. [ Journal Article ]
1992-1994  Bachelor of Science (Physics) - École Normale Supérieure (Paris, France)
1994-1995  Master of Science (Physics) - École Normale Supérieure (Lyon, France)
1995-2000  Ph.D. (Physics) - the Rockefeller University (New York, NY)
2000-2005  Research Fellow (post-doctoral studies) - Laboratory of Immunology, NIAID (Bethesda, MD)
2005-2011  Assistant member - Computational Biology & Immunology programs - Memorial Sloan Kettering (New York, NY)
2012-2015  Associate member - Computational Biology & Immunology programs - Memorial Sloan Kettering (New York, NY)
2016-2020  Earl Stadtman Investigator - Laboratory of Integrative Cancer Immunology (formerly, Cancer and Inflammation Program), Center for Cancer Research, NCI (Bethesda, MD)
2020-present  Senior Investigator (tenured) - Laboratory of Integrative Cancer Immunology, Center for Cancer Research, NCI (Bethesda, MD)
Name Position
Sooraj Achar B.Sc. Postbaccalaureate Fellow (CRTA)
Serifat Adebola B.Sc. Postbaccalaureate Fellow (CRTA)
James Anibal Special Volunteer
Erol Bahadiroglu Postbaccalaureate Fellow (CRTA)
Ratnadeep Mukherjee Ph.D. Postdoctoral Fellow (Visiting)
Emanuel Salazar Cavazos Ph.D. Postdoctoral Fellow (Visiting)
Michael Chen Yeh B.S. Predoctoral Fellow (Graduate Student)