Colm S. O'Huigin, Ph.D.
- Center for Cancer Research
- National Cancer Institute
- Building 37, Room 4140B
- Bethesda, MD 20852
- 301-594-9604
- ohuiginc@mail.nih.gov
RESEARCH SUMMARY
A background in both computational and in experimental biology, leads naturally to an interest in research that interfaces both approaches. In the areas of inflammation and cancer unravelling the complex patterns of change and regulation of molecules of adaptive (MHC, KIR) and innate (Trim5, IL28B) immunity have provided both bioinformatic and experimental challenges that are being met using comparative sequence analysis and inference. Research interest is also turning to the selective forces associated with immunity.
Areas of Expertise
Colm S. O'Huigin, Ph.D.
Research
A background in both computational and in experimental biology, leads naturally to an interest in research that interfaces both approaches. In the areas of inflammation and cancer unravelling the complex patterns of change and regulation of molecules of adaptive (MHC, KIR) and innate (Trim5, IL28B) immunity have provided both bioinformatic and experimental challenges that are being met using comparative sequence analysis and inference. Research interest is also turning to the selective forces associated with immunity. To what extent are rapidly evolving pathogens (HIV, HCV) shaped to escape host immunity? Given the disparity of mutation rates compared with their host, can pathogens or commensals shape host immunity?
Publications
LILRB2 interaction with HLA class I correlates with control of HIV-1 infection
Association of HLA-DRB1-restricted CD4? T cell responses with HIV immune control
Association study of common genetic variants and HIV-1 acquisition in 6,300 infected cases and 7,200 controls
Distinct assembly profiles of HLA-B molecules
Increased incidence and disparity of diagnosis of retinoblastoma patients in Guatemala
Biography
Colm S. O'Huigin, Ph.D.
Dr. O'Huigin heads the Microbiome and Genetic Core Facility. His training in both quantitative and molecular genetics was at the Genetics Dept. of Trinity College, Dublin. He learnt the techniques of molecular evolutionary analysis as a postdoctoral fellow with Wen-Hsiung Li at the Center for Population and Demographic Genetics in Houston Texas. As an EMBO fellow, he worked at the Max-Planck Institute in Tuebingen, Germany with Jan Klein where later he headed a group working on the origins and genetic characteristics of the major histocompatability complex, on organogenesis and on speciation.
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