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Li  Yang, Ph.D.

Li Yang, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute

RESEARCH SUMMARY

Dr. Yang’s research program focuses on the mechanisms underlying tumor-host interplay in cancer metastatic progression. Dr. Yang has contributed to the identification of the immune and inflammatory mediators in the anti- and pro-tumor functional switch of TGF-β, the epigenetic regulation of TGF-β signaling, mechanisms of myeloid cell recruitment in the tumor microenvironment, as well as myeloid TGF-β signaling in cancer immune surveillance and in inflammatory stroke.

As the head of the Tumor Microenvironment and Metastasis Section, Dr. Yang is particularly interested in how tumor suppressors modulate the host immune environment, and the epigenetic mechanisms responsible for tumor cell plasticity and metastatic colonization.

Areas of Expertise

1) cancer metastasis 2) tumor suppressors 3) TGF-β 4) inflammatory and immune response 5) myeloid cells 6) epigenetics

Publications

Selected Key Publications

Induction of DNMT3B by PGE2 and IL6 at Distant Metastatic Sites Promotes Epigenetic Modification and Breast Cancer Colonization

So JY, Skrypek N, Yang HH, Merchant AS, Nelson GW, Chen WD, Ishii H, Chen JM, Hu G, Achyut BR, Yoon EC, Han L, Huang C, Cam MC, Zhao K, Lee MP, Yang L.
Cancer Res. 80(12): 2612-2627, 2020. [ Journal Article ]

miR-130a and miR-145 reprogram Gr-1+CD11b+ myeloid cells and inhibit tumor metastasis through improved host immunity

Ishii H, Vodnala SK, Achyut BR, So JY, Hollander MC, Greten TF, Lal A, Yang L.
Nat Commun. 9(1): 2611, 2018. [ Journal Article ]

TGF-β signaling in myeloid cells is required for tumor metastasis

Pang Y, Gara SK, Achyut BR, Li Z, Yan HH, Day CP, Weiss JM, Trinchieri G, Morris JC, Yang L.
Cancer Discov. 3(8): 936-51, 2013. [ Journal Article ]

Roles of tumor suppressors in regulating tumor-associated inflammation

Yang L, Karin M
Cell Death and Differentiation. 21: 1677-1686, 2014.
Full-Text Article
[ Journal Article ]

Abrogation of TGF beta signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis

Yang L, Huang J, Ren X, Gorska AE, Chytil A, Aakre M, Carbone DP, Matrisian LM, Richmond A, Lin PC, Moses HL.
Cancer Cell. 13(1): 23-35, 2008. [ Journal Article ]

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