Genomics and Bioinformatics Tools
The Branch’s Genomics and Bioinformatics Group explores the relationships between genomic alterations in malignant cells and their response to chemotherapeutic agents using molecular databases at the DNA, RNA and protein levels.
The Miner Suite of bioinformatic software packages developed by the Group are freely available for public use. Visit the links below to learn more about each one.
CellMiner is a database and query tool designed for the cancer research community to facilitate integration of the molecular datasets generated by the Facility/Group? and its collaborators on the NCI-60.
CIMminer produces Clustered Image Maps (CIMS) (i.e., clustered heat maps).
GoMiner leverages the Gene Ontology (GO) database for biological interpretation of microarray data.
MIMminer is a repository of electronically navigatable Kohn Molecular Interaction Maps (MIMs).
SpliceCenter is a suite of user-friendly tools designed for use by every bench biologist who needs to check for the impact of gene splice variation on common molecular biology technologies, including RT-PCR, RNAi, expression microarrays, and peptide-based assays.
AbMiner allows allows users to search for appropriate, commercially available antibodies for research purposes, and to match each antibody to its respective genomic identifiers.