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Urbain Weyemi, Ph.D.

Urbain Weyemi, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Developmental Therapeutics Branch

RESEARCH SUMMARY

Dr. Weyemi is a molecular biologist who investigates the link between genomic instability and metabolism in human diseases. His laboratory uses genomics tools and mouse models to map cellular and energetic metabolic changes associated with genomic instability in tumor cells. Dr. Weyemi’s ultimate goal is to improve the understanding of cancer biology and to discover effective therapeutic targets.                                                                                                        
 

Areas of Expertise

Genomic Stability
Mitochondrial Homeostasis
Redox Homeostasis
Cancer Therapy

Publications

Selected Key Publications

CRISPR metabolic screen identifies ATM and KEAP1 as targetable genetic vulnerabilities in solid tumors

Li H, Liu Y, Xiao Y, Wilson CN, Bai HJ, Jones MD, Wang S, DeVore JE, Maier EY, Durant ST, Boufraqech M, Weyemi U.
Proc Natl Acad Sci U S A. 2023. [ Journal Article ]

NADPH oxidase 4 is a critical mediator in Ataxia telangiectasia disease

Weyemi U, Redon CE, Aziz T, Choudhuri R, Maeda D, Parekh PR, Bonner MY, Arbiser JL, Bonner WM.
Proc Natl Acad Sci U S A. 112(7): 2121-6, 2015. [ Journal Article ]

The histone variant H2A.X is a regulator of the epithelial-mesenchymal transition

Weyemi U, Redon CE, Choudhuri R, Aziz T, Maeda D, Boufraqech M, Parekh PR, Sethi TK, Kasoji M, Abrams N, Merchant A, Rajapakse VN, Bonner WM.
Nat Commun. 2016. [ Journal Article ]

Histone H2AX promotes neuronal health by controlling mitochondrial homeostasis

Weyemi U, Paul BD, Bhattacharya D, Malla AP, Boufraqech M, Harraz MM, Bonner WM, Snyder SH.
Proc Natl Acad Sci U S A. 116(15): 7471-7476, 2019. [ Journal Article ]

Metabolism-focused CRISPR screen unveils mitochondrial pyruvate carrier 1 as a critical driver for PARP inhibitor resistance in lung cancer

Furusawa T, Cavero R, Liu Y, Li H, Xu X, Andresson T, Reinhold W, White O, Boufraqech M, Meyer TJ, Hartmann O, Diefenbacher ME, Pommier Y, Weyemi U.
Mol Carcinog. 2024.
Full-Text Article
[ Journal Article ]

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Alumni

Jessie Xiao, now at the MIT Biology Graduate Program
Jessie Xiao, moved on to: PhD at MIT
07/2022-08/2023
Postbaccalaureate Researcher