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Vladimir L. Larionov, Ph.D.

Vladimir L. Larionov, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Developmental Therapeutics Branch

RESEARCH SUMMARY

Our overall goal is to understand why particular chromosomal regions and genes are prone to generate genomic disorders. Relevant specialized features of the human genome, including some that are especially relevant to cancer, have increasingly become the focus of my research. Involved are: 1) aspects of gene duplication and evolution and 2) specialized features of mitosis -- particularly the centromere structure and function that underlie proper chromosome segregation.

Areas of Expertise

1) gene therapy

Publications

Selected Key Publications

A novel assay to screen siRNA libraries identifies protein kinases required for chromosome transmission

Liskovykh M, Goncharov NV, Petrov N, Aksenova V, Pegoraro G, Ozbun LL, Reinhold WC, Varma S, Dasso M, Kumeiko V, Masumoto H, Earnshaw WC, Larionov V, Kouprina N.
Genome Res. 29(10): 1719-32, 2019. [ Journal Article ]

Systematic Analysis of Compounds Specifically Targeting Telomeres and Telomerase for Clinical Implications in Cancer Therapy

Lee HS, Carmena M, Liskovykh M, Peat E, Kim JH, Oshimura M, Masumoto H, Teulade-Fichou MP, Pommier Y, Earnshaw WC, Larionov V, Kouprina N.
Cancer Res. 78(21): 6282-96, 2018. [ Journal Article ]

Variation in human chromosome 21 ribosomal RNA genes characterized by TAR cloning and long-read sequencing

Kim JH, Dilthey AT, Nagaraja R, Lee HS, Koren S, Dudekula D, Wood Iii WH, Piao Y, Ogurtsov AY, Utani K, Noskov VN, Shabalina SA, Schlessinger D, Phillippy AM, Larionov V
Nucleic Acids Res. 46(13): 6712-25, 2018. [ Journal Article ]

Effects of Anticancer Drugs on Chromosome Instability and New Clinical Implications for Tumor-Suppressing Therapies

Lee HS, Lee NC, Kouprina N, Kim JH, Kagansky A, Bates S, Trepel JB, Pommier Y, Sackett D, Larionov V.
Cancer Res. 76(4): 902-11, 2016. [ Journal Article ]

Job Vacancies

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Team

Staff Scientist
Jung-Hyun Kim, Ph.D.
Research Biologist
Hee-sheung Lee, Ph.D.
Postdoctoral Fellow (Visiting)
Mikhail Liskovykh, Ph.D.
Scientist (Contr)
Vladimir Noskov, Ph.D.
Postdoctoral Fellow (Visiting)
Nikolai Petrov, Ph.D.