Breadcrumb

James H. Doroshow, M.D.

James H. Doroshow, M.D.

  • Center for Cancer Research
  • National Cancer Institute
Developmental Therapeutics Branch

RESEARCH SUMMARY

Our laboratory focuses on the role of oxidant-mediated signalling in cytokine-, growth factor- and drug-related alterations of tumor cell proliferation. We are particularly interested in how the generation of reactive oxygen species by the members of the NADPH oxidase gene family contributes to context-driven tumor initiation, progression, and metastasis. We are actively engaged in the development of novel small molecule inhibitors of these proteins both as chemical probes and as potential therapeutic agents. Our other active research focus is in the development of targeted anticancer drugs, beginning with the validation of novel pharmacodynamic assays that will be used to demonstrate proof-of-mechanism for these molecules. We employ new pre-clinical models to qualify these assays for use in phase 0, 1, and 2 clinical trials conducted in our early drug development clinic.

Areas of Expertise

1) reactive oxygen metabolism 2) NADPH oxidases 3) drug development 4) pharmacodynamics 5) pre-clinical tumor models 6) early phase clinical trials

Information for Patients

Learn more about our clinical trials and the highly specialized care teams that lead them. 

Publications

Selected Key Publications

Clinical Evolution of Epithelial-Mesenchymal Transition in Human Carcinomas

Navas T, Kinders RJ, Lawrence SM, Ferry-Galow KV, Borgel S, Hollingshead MG, Srivastava AK, Alcoser SY, Makhlouf HR, Chuaqui R, Wilsker DF, Konaté MM, Miller SB, Voth AR, Chen L, Vilimas T, Subramanian J, Rubinstein L, Kummar S, Chen AP, Bottaro DP, Doroshow JH, Parchment RE
Cancer Res. 80(2): 304-18, 2020. [ Journal Article ]

RNA Sequencing of the NCI-60: Integration into CellMiner and CellMiner CDB

Reinhold WC, Varma S, Sunshine M, Elloumi F, Ofori-Atta K, Lee S, Trepel JB, Meltzer PS, Doroshow JH, Pommier Y
Cancer Res. 79(13): 3514-24, 2019. [ Journal Article ]

Modernizing Clinical Trials for Patients With Cancer

Sharpless NE, Doroshow JH
JAMA. 321(5): 447-48, 2019. [ Journal Article ]

The National Cancer Institute ALMANAC: A Comprehensive Screening Resource for the Detection of Anticancer Drug Pairs with Enhanced Therapeutic Activity

Holbeck SL, Camalier R, Crowell JA, Govindharajulu JP, Hollingshead M, Anderson LW, Polley E, Rubinstein L, Srivastava A, Wilsker D, Collins JM, Doroshow JH
Cancer Res. 77(13): 3564-76, 2017. [ Journal Article ]

Translational research in oncology--10 years of progress and future prospects

Doroshow JH and Kummar S.
Nat Rev Clin Oncol. 11: 649-662, 2014. [ Journal Article ]

Job Vacancies

There are no open positions at this time. Check back again later, or take a look at CCR's Careers page.

Team

Adjunct Staff Clinician
Fernanda Arnaldez, M.D.
Research Biologist
Guojian Jiang, Ph.D.
Technical Laboratory Manager
Agnes Juhasz, Ph.D.
Nurse Practitioner (Contr)
Lamin Juwara, CRNP
Adjunct Staff Clinician
Larissa Korde, M.D.
Research Biologist
Jiamo Lu, Ph.D.
Research Fellow
Jennifer Meitzler, Ph.D.
Adjunct Staff Clinician
Geraldine O'Sullivan Coyne, M.D.
Staff Scientist
Yongzhong Wu, Ph.D.