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Andre  Nussenzweig, Ph.D.

Andre Nussenzweig, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute

RESEARCH SUMMARY

Dr. Nussenzweig is a leading contributor to the study of mechanisms that maintain genomic stability and prevent cancer. His laboratory has elucidated many fundamental features of DNA damage and repair proteins and revealed the critical role they play in both normal and pathogenic states. Ongoing studies have emphasized the importance of DNA repair pathways as drivers of specific hematological malignancies and as contributors to chemoresistance/sensitivity in breast and ovarian cancers. The goal of his program is to use hypothesis-driven approaches to develop therapeutic strategies in the treatment of cancers.

Areas of Expertise

1) genomic Instability, 2) DNA damage/repair, 3) breast/ovarian cancers, 4) recombination/replication, 5) chromosomal translocations, 6) adult/pediatric leukemias

Publications

Selected Recent Publications

Neuronal enhancers are hotspots for DNA single-strand break repair

Wu W, Hill SE, Nathan WJ, Paiano J, Callen E, Wang D, Shinoda K, van Wietmarschen N, Colón-Mercado JM, Zong D, De Pace R, Shih HY, Coon S, Parsadanian M, Pavani R, Hanzlikova H, Park S, Jung SK, McHugh PJ, Canela A, Chen C, Casellas R, Caldecott KW, Ward ME, Nussenzweig A.
Nature. doi: 10.1038/s41586-021-03468-5. Online ahead of print : [ Journal Article ]

Repeat expansions confer WRN dependence in microsatellite-unstable cancers

van Wietmarschen N, Sridharan S, Nathan WJ, Tubbs A, Chan EM, Callen E, Wu W, Belinky F, Tripathi V, Wong N, Foster K, Noorbakhsh J, Garimella K, Cruz-Migoni A, Sommers JA, Huang Y, Borah AA, Smith JT, Kalfon J, Kesten N, Fugger K, Walker RL, Dolzhenko E, Eberle MA, Hayward BE, Usdin K, Freudenreich CH, Brosh RM Jr, West SC, McHugh PJ, Meltzer PS, Bass AJ, Nussenzweig A.
Nature. 586:292-298: 292-298, 2020. [ Journal Article ]

Dual Roles of Poly(dA:dT) Tracts in Replication Initiation and Fork Collapse

Tubbs A, Sridharan S, van Wietmarschen N, Maman Y, Callen E, Stanlie A, Wu W, Wu X, Day A, Wong N, Yin M, Canela A, Fu H, Redon C, Pruitt SC, Jaszczyszyn Y, Aladjem MI, Aplan PD, Hyrien O, Nussenzweig A
Cell. 174(5) : 1127-1142, 2018. [ Journal Article ]

Genome Organization Drives Chromosome Fragility

Canela A, Maman Y, Jung S, Wong N, Callen E, Day A, Kieffer-Kwon K, Pekowska A, Zhang H, Rao S, Huang S, Mckinnon PJ, Aplan PD, Pommier Y, Lieberman Aiden E, Casellas R, Nussenzweig A
Cell. 170(3): 507–521, 2017. [ Journal Article ]

DNA Breaks and End Resection Measured Genome-wide by End Sequencing

Canela A, Sridharan S, Sciascia N, Tubbs A, Meltzer P, Sleckman BP, Nussenzweig A
Molecular Cell. 63(5) : 898-911, 2016. [ Journal Article ]

Job Vacancies

Position Degree Required Contact Name Contact Email
Post-doctoral Fellow - DNA damage, DNA repair, computational biology, genomics Ph.D. or equivalent Sam John sam.john@nih.gov
Post-doctoral Fellow - DNA damage, DNA repair, genomics Ph.D. or equivalent Sam John sam.john@nih.gov

Team

Postdoctoral Fellow (Visiting)
Wei Wu, Ph.D.
Postdoctoral Fellow (Visiting)
Raphael Souza Pavani, Ph.D.
Scientist (Contr.)
Veenu Tripathi, Ph.D.
Postdoctoral Fellow (Visiting)
Dongpeng Wang, Ph.D.
Postdoctoral Fellow (Visiting)
Gabriel Eduardo de Matos Rodrigues, Ph.D.
Postdoctoral Fellow (CRTA)
Natasha Koussa, Ph.D.
Postdoctoral fellow (Visiting)
Jia-Cheng Liu, Ph.D.
Postdoctoral Fellow (CRTA)
William J. Nathan, Ph.D.
Postbaccalaureate (CRTA)
Santiago Noriega
Postdoctoral Fellow (Visiting)
Ajith Pankajam, Ph.D.

Alumni

Nicholas Zolnerowich
Nicholas Zolnerowich
(2018-2021)
Postbaccalaureate (CRTA)
Kenta Shinoda, Ph.D.
Kenta Shinoda, Ph.D.
(2015-2021)
Postdoctoral Fellow
Niek van Wietmarschen, Ph.D.
Niek van Wietmarschen, Ph.D.
(2017-2021)
Postdoctoral Fellow
Sriram Vakulabaranam Sridharan, Ph.D.
Sriram Vakulabaranam Sridharan, Ph.D.
(2015-2020)
Postdoctoral Fellow
Jacob Paiano
Jacob Paiano
(2016-2020)
Graduate Student
Anthony Tubbs, Ph.D.
Anthony Tubbs, Ph.D.
(2014-2020)
Postdoctoral Fellow
Nicholas Sciascia
Nicholas Sciascia
(2015-2019)
Graduate Student
Andres Rodriguez, Ph.D.
Andres Rodriguez, Ph.D.
(2013-2018)
Research Fellow
Andre Stanlie, Ph.D.
Andre Stanlie, Ph.D.
(2014-2019)
Postdoctoral Fellow
Yaakov Maman, Ph.D.
Yaakov Maman, Ph.D.
(2016-2019)
Staff Scientist
Arnab Ray Chaudhuri, Ph.D.
Arnab Ray Chaudhuri, Ph.D.
2013-2017
Postdoctoral fellow
Aysegul Ergen, Ph.D.
Aysegul Ergen, Ph.D.
(2012-2015)
Postdoctoral Fellow
Robert (Babak) Faryabi, Ph.D.
Robert (Babak) Faryabi, Ph.D.
(2010 - 2015)
Research Fellow
Margarida A. Santos, Ph.D.
Margarida A. Santos, Ph.D.
(2008 - 2015)
Research Fellow
Frederica Polato, Ph.D.
Frederica Polato, Ph.D.
(2006 - 2014)
Research Fellow
Jacqueline Barlow, Ph.D.
Jacqueline Barlow, Ph.D.
(2008 - 2014)
Postdoctoral Fellow
Marina Kozak, Ph.D.
Marina Kozak, Ph.D.
(2010 - 2012)
Postdoctoral Fellow
Sam Bunting, Ph.D.
Sam Bunting, Ph.D.
(2006 - 2012)
Postdoctoral Fellow
Jeremy A. Daniel, Ph.D.
Jeremy A. Daniel, Ph.D.
(2006 - 2011)
Postdoctoral Fellow
Simone Difilippantonio, Ph.D.
Simone Difilippantonio, Ph.D.
(2000 - 2008)
Research Fellow, Staff Scientist
Manuela Pellegrini, Ph.D.
Manuela Pellegrini, Ph.D.
(2004 - 2007)
Postdoctoral Fellow
Alicia Lee,  Ph.D.
Alicia Lee, Ph.D.
(2002 - 2006)
Predoctoral Fellow
Oscar Fernandez-Capetillo, Ph.D.,
Oscar Fernandez-Capetillo, Ph.D.,
(2001 - 2004)
Postdoctoral Fellow
Quinn Tai
Quinn Tai
(2014 - 2015)
Summer Student
Nadia Finkel
Nadia Finkel
(2014 - 2015)
Summer Student