Elsa Callen Moreu, Ph.D.

Elsa Callen Moreu, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Laboratory of Genome Integrity


Dr. Callen Moreu has made major contributions in dissecting the mechanisms involved in DNA double-strand break repair with a focus towards understanding the role of DNA damage and repair proteins as contributors to chemoresistance/sensitivity in breast and ovarian cancers.

Areas of Expertise

DNA Damage And Repair
Ataxia Telangiectasia Protein (ATM)
DNA Repair Pathways
Genomic Instability
Cancer Therapeutics
BRCA1 And Breast Cancer


Selected Recent Publications

BRCA1 Mutational Complementation Induces Synthetic Viability

Nacson J, Di Marcantonio D, Wang Y, Bernhardy AJ, Clausen E, Hua X, Cai KQ, Martinez E, Feng W, Callén E, Wu W, Gupta GP, Testa JR, Nussenzweig A, Sykes SM, Johnson N.
Cell. 78(5): 951-959, 2020. [ Journal Article ]

Loss of H3K36 Methyltransferase SETD2 Impairs V(D)J Recombination during Lymphoid Development

Chu SH, Chabon JR, Matovina CN, Minehart JC, Chen BR, Zhang J, Kumar V, Xiong Y, Callen E, Hung PJ, Feng Z, Koche RP, Liu XS, Chaudhuri J, Nussenzweig A, Sleckman BP, Armstrong SA.
iScience. 23(3): 100941, 2020. [ Journal Article ]

ATM and PRDM9 regulate SPO11-bound recombination intermediates during meiosis

Paiano J, Wu W, Yamada S, Sciascia N, Callen E, Paola Cotrim A, Deshpande RA, Maman Y, Day A, Paull TT, Nussenzweig A.
Nat Commun. 11(1): 857, 2020. [ Journal Article ]

53BP1 Enforces Distinct Pre- and Post-resection Blocks on Homologous Recombination

Callen E, Zong D, Wu W, Wong N, Stanlie A, Ishikawa M, Pavani R, Dumitrache LC, Byrum AK, Mendez-Dorantes C, Martinez P, Canela A, Maman Y, Day A, Kruhlak MJ, Blasco MA, Stark JM, Mosammaparast N, McKinnon PJ, Nussenzweig A.
Mol Cell. 77(1): 26-38.e7, 2020. [ Journal Article ]

Topoisomerase II- Induced Chromosome Breakage and Translocation Is Determined by Chromosome Architecture and Transcriptional Activity

Canela A, Maman Y, Huang SN, Wutz G, Tang W, Zagnoli-Vieira G, Callen E, Wong N, Day A, Peters JM, Caldecott KW, Pommier Y, Nussenzweig A.
Mol Cell. 75(2: 252-266.e8, 2019. [ Journal Article ]