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Laurie T. Krug, Ph.D.

Laurie T. Krug, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
HIV and AIDS Malignancy Branch

RESEARCH SUMMARY

Dr. Krug applies novel molecular approaches to define the gammaherpesvirus proteins and host signaling networks that are required for different stages of chronic infection. Recent findings from her lab indicate that targeting host transcription factors decreases the virus load in B lymphocytes, a critical reservoir of viral resistance. Her lab also discovered vital functions for viral proteins in an animal model of infection that were deemed dispensable in cell culture systems. Mechanistic studies of the virus-host interplay are underway with the goal to identify new, effective interventions to treat and prevent cancers driven by Epstein-Barr virus and Kaposi’s sarcoma-associated herpesvirus.

Areas of Expertise

1) gammaherpesvirus pathogenesis, 2) animal models of gamma herpesvirus disease,
3) oncogenic processes of viruses, 4) viral subversion of host processes,
5) viral subversion of B cell development, 6) immune response to viral infections

Publications

Selected Key Publications

Gammaherpesvirus-infected germinal center cells express a distinct immunoglobulin repertoire

1. Zelazowska MA, Dong Q, Plummer JB, Zhong Y, Liu B, Krug LT, McBride KM
Life Sci Alliance. 3(3): e201900526, 2020. [ Journal Article ]

Combinatorial loss of the enzymatic activities of viral uracil-DNA glycosylase and viral dUTPase impairs murine gammaherpesvirus pathogenesis and leads to increased recombination-based deletion in the viral genome

Dong Q, Smith KR, Oldenburg DG, Shapiro M, Schutt WR, Malik L, Plummer JB, Mu Y, MacCarthy T, White DW, McBride KM, Krug LT
MBio. 9(5): e01831-18, 2018. [ Journal Article ]

Ablation of STAT3 in the B cell compartment restricts gammaherpesvirus latency in vivo

Reddy SS, Foreman HC, Sioux TO, Park GH, Poli V, Reich NC, Krug LT
MBio. 7(4): e00723-16, 2016. [ Journal Article ]

Viral FGARAT ORF75A promotes early events in lytic infection and gammaherpesvirus pathogenesis in mice

Van Skike ND, Minkah NK, Hogan CH, Wu G, Benziger PT, Oldenburg DG, Kara M, Kim-Holzapfel DM, White DW, Tibbetts SA, French JB, Krug LT
PLoS Pathogens. 14(2): e1006843, 2019. [ Journal Article ]

A codon-shuffling method to prevent reversion during production of replication-defective herpesvirus stocks: Implications for herpesvirus vaccines

Li G, Ward C, Yeasmin R, Skiena S, Krug LT, Forrest JC.
Scientific Reports. 7(44404): srep44404, 2017. [ Journal Article ]

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