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Laurie T. Krug, Ph.D.

Laurie T. Krug, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
HIV and AIDS Malignancy Branch

RESEARCH SUMMARY

Dr. Krug aims to develop novel animal models of infection and apply state of art molecular approaches to define the gammaherpesvirus proteins and host signaling networks that are required for different stages of chronic infection. Recent findings from her lab indicate that targeting host transcription factors decreases the virus load in B lymphocytes, a critical reservoir of viral resistance.  Mechanistic studies of the virus-host interplay are underway with the goal to identify new, effective interventions to treat and prevent cancers driven by Epstein-Barr virus and Kaposi sarcoma herpesvirus. Development of vaccines that elicit a protective immune response to reduce virus load and incidence of virus-driven disease is a collaborative effort recently launched in the laboratory.

Areas of Expertise

Gamma Herpesvirus Pathogenesis
Animal Models of Gamma Herpesvirus Disease
Oncogenic Processes of Viruses
Protective immune responses elicited by vaccines

Publications

Selected Key Publications

A replication-deficient gammaherpesvirus vaccine protects mice from lytic disease and reduces latency establishment

Bland WA, Mitra D, Owens S, McEvoy K, Hogan CH, Boccuzzi L, Kirillov V, Meyer TJ, Khairallah C, Sheridan BS, Forrest JC, Krug LT
NPJ Vaccines. 9(1): 116, 2024.
Full-Text Article
[ Journal Article ]

Multifaceted roles for STAT3 in gammaherpesvirus latency revealed through in vivo B cell knockout models

Hogan CH, Owens SM, Reynoso GV, Liao Y, Meyer TJ, Zelazowska MA, Liu B, Li X, Grosskopf AK, Khairallah C, Kirillov V, Reich NC, Sheridan BS, McBride KM, Gewurz BE, Hickman HD, Forrest JC, Krug LT
mBio. 15(2): e0299823, 2024.
Full-Text Article
[ Journal Article ]

Uracil-DNA glycosylase of murine gammaherpesvirus 68 binds cognate viral replication factors independently of its catalytic residues.

Smith KR, Paul S, Dong Q, Anannya O, Oldenburg DG, Forrest JC, McBride KM, Krug LT.
mSphere. 8(5): e0027823, 2023.
Full-Text Article
[ Journal Article ]

IKKα-Mediated Noncanonical NF-κB Signaling Is Required To Support Murine Gammaherpesvirus 68 Latency In Vivo

1. Cieniewicz B, Kirillov V, Daher I, Li X, Oldenburg DG, Dong Q, Bettke JA, Marcu KB, Krug LT
Journal of Virology. 96(10): e0002722, 2022. [ Journal Article ]

Conquering the Host: Determinants of Pathogenesis Learned from Murine Gammaherpesvirus 68

Wang Y, Tibbetts SA, Krug LT
Annu Rev Virol. 14(2)8(1): 349-371, 2021.
Full-Text Article
[ Journal Article ]

Job Vacancies

Position Degree Required Contact Name Contact Email
Postdoctoral Fellow - gammaherpesvirus, vaccine Ph.D. or equivalent Laurie Krug laurie.krug@nih.gov

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