Laurie T. Krug, Ph.D.

Laurie T. Krug, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
HIV and AIDS Malignancy Branch


Dr. Krug applies novel molecular approaches to define the gammaherpesvirus proteins and host signaling networks that are required for different stages of chronic infection. Recent findings from her lab indicate that targeting host transcription factors decreases the virus load in B lymphocytes, a critical reservoir of viral resistance. Her lab also discovered vital functions for viral proteins in an animal model of infection that were deemed dispensable in cell culture systems. Mechanistic studies of the virus-host interplay are underway with the goal to identify new, effective interventions to treat and prevent cancers driven by Epstein-Barr virus and Kaposi’s sarcoma-associated herpesvirus.

Areas of Expertise

Gamma Herpesvirus Pathogenesis
Animal Models of Gamma Herpesvirus Disease
Oncogenic Processes of Viruses
Viral Subversion of Host Processes
Viral Subversion of B Cell Development


Selected Key Publications

IKKα-Mediated Noncanonical NF-κB Signaling Is Required To Support Murine Gammaherpesvirus 68 Latency In Vivo

1. Cieniewicz B, Kirillov V, Daher I, Li X, Oldenburg DG, Dong Q, Bettke JA, Marcu KB, Krug LT
Journal of Virology. 96(10): e0002722, 2022. [ Journal Article ]

Combinatorial loss of the enzymatic activities of viral uracil-DNA glycosylase and viral dUTPase impairs murine gammaherpesvirus pathogenesis and leads to increased recombination-based deletion in the viral genome

Dong Q, Smith KR, Oldenburg DG, Shapiro M, Schutt WR, Malik L, Plummer JB, Mu Y, MacCarthy T, White DW, McBride KM, Krug LT
MBio. 9(5): e01831-18, 2018. [ Journal Article ]

Ablation of STAT3 in the B cell compartment restricts gammaherpesvirus latency in vivo

Reddy SS, Foreman HC, Sioux TO, Park GH, Poli V, Reich NC, Krug LT
MBio. 7(4): e00723-16, 2016. [ Journal Article ]

Viral FGARAT ORF75A promotes early events in lytic infection and gammaherpesvirus pathogenesis in mice

Van Skike ND, Minkah NK, Hogan CH, Wu G, Benziger PT, Oldenburg DG, Kara M, Kim-Holzapfel DM, White DW, Tibbetts SA, French JB, Krug LT
PLoS Pathogens. 14(2): e1006843, 2019. [ Journal Article ]

A codon-shuffling method to prevent reversion during production of replication-defective herpesvirus stocks: Implications for herpesvirus vaccines

Li G, Ward C, Yeasmin R, Skiena S, Krug LT, Forrest JC.
Scientific Reports. 7(44404): srep44404, 2017. [ Journal Article ]

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