H. Efsun Arda, Ph.D.

H. Efsun Arda, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute


Dr. Arda spearheaded the development of genomic and epigenetic analysis of primary pancreatic cells obtained from children and adult donors. Her research focuses on understanding the genomic information that governs development, differentiation and function of pancreatic cell lineages.

Areas of Expertise

Regulation of Gene Expression
Pancreas Development


Selected Recent Publications

Single-cell transcriptome and accessible chromatin dynamics during endocrine pancreas development

Eliza Duvall, Cecil M. Benitez, Krissie Tellez, Martin Enge, Philip T. Pauerstein, Lingyu Li, Songjoon Baek, Stephen R. Quake, Jason P. Smith, Nathan C. Sheffield, Seung K. Kim and H. Efsun Arda.
Single-cell transcriptome and accessible chromatin dynamics during endocrine pancreas development. 119/No. 26: 12, 2022.
Full-Text Article
[ Journal Article ]

A Chromatin Basis for Cell Lineage and Disease Risk in the Human Pancreas

Arda HE, Tsai J, Rosli Y, Giresi P, Bottino R, Greenleaf WJ, Chang HY, Kim SK
Cell Systems. 2018. [ Journal Article ]

Single cell transcriptome analysis of human pancreas reveals transcriptional signatures of aging and somatic mutation patterns

Enge M, Arda HE, Mignardi M, Beausang J, Bottino R, Kim SK, and Quake SR.
Cell. 2017. [ Journal Article ]

Age-Dependent Pancreatic Gene Regulation Reveals Mechanisms Governing Human β Cell Function

Arda HE, Li L, Tsai J, Torre EA, Rosli Y, Peiris H, Spitale RC, Dai C, Gu X, Qu K, Wang P, Wang J, Grompe M, Scharfmann R, Snyder MS, Bottino R, Powers AC, Chang HY, and Kim SK.
Cell Metabolism. 23: 909-920, 2016. [ Journal Article ]

Gene Regulatory Networks Governing Pancreas Development

Arda HE, Benitez CM, and Kim SK.
Developmental Cell. 25: 5-13, 2013. [ Journal Article ]

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