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Eugene Valkov in the lab.

Eugene Valkov, D.Phil.

  • Center for Cancer Research
  • National Cancer Institute
RNA Biology Laboratory

RESEARCH SUMMARY

Eugene Valkov leads a team of scientists investigating the molecular mechanisms by which messenger RNA (mRNA) is regulated and degraded. We combine biochemical reconstitution with biophysical, structural, and cellular analyses in a diverse methodological approach. Our team contributed toward the development of novel protocols for the recombinant production and biochemical characterization of many human factors and complexes with principal roles in the late stages of gene expression.

Areas of Expertise

1) biochemical reconstitution, 2) RNA decay and surveillance pathways, 3) translational control, 4) integrative structural analysis, 5) RNA-binding proteins, 6) biomolecular interactions

Publications

Selected Recent Publications

Reconstitution of recombinant human CCR4-NOT reveals molecular insights into regulated deadenylation

Raisch T, Chang CT, Levdansky Y, Muthukumar S, Raunser S, Valkov E.
Nature Communications. 10(1): 3173, 2019. [ Journal Article ]

Structural motifs in eIF4G and 4E-BPs modulate their binding to eIF4E to regulate translation initiation in yeast

Gruner S, Weber R, Peter D, Chung MY, Igreja C, Valkov E, Izaurralde E.
Nucleic Acids Research. 46: 6893-6908, 2018. [ Journal Article ]

GIGYF1/2 proteins use auxiliary sequences to selectively bind to 4EHP and repress target mRNA expression

Peter D, Weber R, Sandmeir F, Wohlbold L, Helms S, Bawankar P, Valkov E, Igreja C, Izaurralde E.
Genes & Development. 31: 1147-1161, 2017. [ Journal Article ]

The structures of eIF4E-eIF4G complexes reveal an extended interface to regulate translation initiation

Gruner S, Peter D, Weber R, Wohlbold L, Chung MY, Weichenrieder O, Valkov E, Igreja C, Izaurralde E.
Molecular Cell. 64: 467-479, 2016. [ Journal Article ]

Structure of the Dcp2–Dcp1 mRNA-decapping complex in the activated conformation

Valkov E, Muthukumar S, Chang CT, Jonas S, Weichenrieder O, Izaurralde E.
Nature Structural and Molecular Biology. 23: 574-9, 2016. [ Journal Article ]

Job Vacancies

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Team

Postbaccalaureate Student (CRTA)
Adrianna Hernandez
Postdoctoral Fellow (Visiting)
Wataru Horikawa, Ph.D.
Graduate Student (Visiting)
Yevgen Levdansky
Postdoctoral Fellow (visiting)
Filip Peković, Ph.D.
Postbaccalaureate Student (CRTA)
Leah Pitman
Research Fellow
Khadija Rebbani, Ph.D.
Postdoctoral Fellow (CRTA)
Eric Simko, Ph.D.
Postdoctoral Fellow (Visiting)
David Turner, Ph.D.