CCR Cancer Moonshot Projects


CCR is proud to participate in the Cancer Moonshot, one of NCI’s key initiatives.  The Cancer Moonshot seeks to accelerate cancer research to make more therapies available to more patients, while also improving our ability to prevent cancer and detect it at an early stage.  Moonshot projects are based on a 2016 Blue Ribbon Panel Report, which describes 10 transformative research recommendations for achieving the Cancer Moonshot's ambitious goal of making a decade's worth of progress in cancer prevention, diagnosis, and treatment in just 5 years.  Below are CCR’s funded projects:

CCR Moonshot Project

Blue Ribbon Panel Recommendation

CCR Project Leaders

Rare Tumor Patient Engagement Network

Goal:  Build a national network to study selected rare pediatric and adult tumors and develop a network of clinical trials.

CONNECT: Comprehensive Oncology Network Evaluating Rare CNS Tumors. CONNECT aims to advance the understanding of rare adult central nervous system (CNS) cancers by establishing and fostering patient-advocacy-provider partnerships and networks to improve approaches to care and treatment.

MyPART: Moonshot Pediatric, Adolescent, and Adult Rare Tumors Network (Coming Soon).

Establish a network for direct patient involvement

Terri Armstrong

Mark Gilbert

Karlyne Reilly

Brigitte Widemann

Goal:  Build a trans-NIH cell-based therapy center for development and dissemination of cutting-edge immunotherapy approaches.

Create a translational science network devoted exclusively to immunotherapy.

Nick Restifo

NCI Program for Natural Products Discovery

Goal:  Develop a library of 1 million pre-fractionated natural product pools to be made available for screening to the extramural community and to provide natural products screening expertise and infrastructure.

Develop new cancer technologies

Barry O’Keefe

Joel Schneider

CCR Moonshot Clinical Trials

Blue Ribbon Panel Recommendation

CCR Project Leaders

Lymphoma Basket Trial: Divide and Conquer with Combinations (DiCoCo)

Goal: Conduct a multi-arm master clinical protocol to test rational doublets of targeted agents in molecularly-defined subsets of relapsed/refractory diffuse large B-cell lymphoma (DLBCL) and identify mechanisms of resistance.

Develop ways to overcome cancer’s resistance to therapy

Lou Staudt

Wyndham Wilson

Graft-Versus-Host Disease (GVHD) Symptom Management

Goal:  Development and psychometric testing of a pediatric chronic symptom scale (PCSS).

Minimize cancer treatment’s debilitating side effects

Sandra Mitchell, DCCPS

Lori Wiener

Prostate Imaging Clinical Trial

Goal:  To determine the clinical impact of PET imaging of prostate-specific membrane antigen (PSMA) on patients with high-risk prostate cancer who have negative conventional imaging (CT and bone scan).

Develop new cancer technologies

Pete Choyke

Bill Dahut

Doug Figg

James Gulley

Ravi Madan

David Vanderweele