Joel P. Schneider, Ph.D.
- Center for Cancer Research
- National Cancer Institute
- Building 376, Room 104
- Frederick, MD 21702-1201
The Schneider group designs and characterizes novel materials for use in drug delivery, the delivery of cells, and antibacterial therapy.
Areas of Expertise
1) soft materials 2) drug delivery 3) self-assembly 4) cell penetrating peptides 5) peptide design, synthesis and characterization
Our group develops novel materials for use in the delivery of therapeutics and as antibacterial agents. We are particularly interested in peptide and protein-based hydrogel materials formed by self-assembly mechanisms. Our work spans molecular conception, materials synthesis, nano- and bulk mechanical materials characterization, cell-material interactions, biocompatibility, and assessment of performance efficacy. Our basic research establishes how material composition and structure influences material function, and lays the foundation to ultimately translate materials to the clinic. We also develop and study membrane-perturbing peptides as drug delivery vehicles.
Surface-fill Hydrogel Attenuates the Oncogenic Signature of Complex Anatomical Surface Cancer in a Single Application
Uncoupling the folding-function paradigm of lytic peptides to deliver impermeable inhibitors of intracellular protein-protein interactions
Multiphase assembly of small molecule microcrystalline peptide hydrogel allows immunomodulatory combination therapy for long-term heart transplant survival
De novo design of selective membrane-active peptides via enzymatic control of their conformational bias on the cell surface
Joel P. Schneider, Ph.D.
Dr. Schneider received his Ph.D. in Organic Chemistry from Texas A&M University with Jeffery Kelly and then went on to the University of Pennsylvania School of Medicine, Department of Biochemistry and Biophysics where he was a George W. Raiziss Fellow with William DeGrado studying protein design. In 1999, he began his independent career at the University of Delaware as an assistant professor of Chemistry and Biochemistry and was promoted to associate and then full professor in 2009 with a secondary appointment in Materials Science and Engineering. He joined the NCI in 2010 as lab Chief of the newly established Chemical Biology Laboratory and was later appointed Deputy Director in 2015. He currently serves as the president of the American Peptide Society and Executive Editor of Biopolymers-Peptide Science.
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