Kazusa Ishii, M.D., M.P.H.

Kazusa Ishii, M.D., M.P.H.

  • Center for Cancer Research
  • National Cancer Institute
Center for Immuno-Oncology


Dr. Kazusa Ishii researches cell therapy for various hematologic malignancies and non-malignant diseases. Her research focuses on 1) identification of therapeutically targetable antigens, 2) discovery, pre-clinical development and clinical translation of novel cell therapies, and 3) improving our mechanistic understanding of how T-cell-mediated therapies and the host’s immune environment affect clinical responses and disease phenotypes.

Areas of Expertise

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Selected Recent Publications

Multi-tiered approach to detect autoimmune cross-reactivity of therapeutic T cell receptors

Ishii K*, Davies JS, Sinkoe AL, Nguyen KA, Norberg SM, McIntosh CP, Kadakia T, Serna C, Rae Z, Kelly MC, Hinrichs CS*. *co-corresponding
Science Advances. 9(30): eadg9845, 2023.
Full-Text Article
[ Journal Article ]

Perforin-deficient CAR T cells recapitulate late-onset inflammatory toxicities observed in patients

Ishii K*, Pouzolles M, Chien CD, Erwin-Cohen RA, Kohler ME, Qin H, Lei H, Kuhn S, Ombrello AK, Dulau-Florea A, Eckhaus MA, Shalabi H, Yates B, Lichtenstein DA, Zimmermann VS, Kondo T, Shern JF, Young HA, Taylor N, Shah NN*, Fry TJ*. *co-corresponding
J Clin Invest. 130(10): 5425-5443, 2020. [ Journal Article ]

Murine pre-B-cell ALL induces T-cell dysfunction not fully reversed by introduction of a chimeric antigen receptor

Qin H, Ishii K, Nguyen S, Su PP, Burk CR, Kim BH, Duncan BB, Tarun S, Shah NN, Kohler ME, Fry TJ.
Blood. 132(18): 1899-1910, 2018. [ Journal Article ]

Applying a clinical lens to animal models of CAR-T cell therapies

Duncan BB, Dunbar CE, Ishii K*. *corresponding
Mol Ther Methods Clin Dev. 27: 17-31, 2022. [ Journal Article ]

Novel immunotherapeutic approaches for the treatment of acute leukemia (myeloid and lymphoblastic)

Ishii K, Barrett AJ.
Ther Adv Hematol. 7(1): 17-39, 2016. [ Journal Article ]

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