Tom  Misteli, Ph.D.
Tom Misteli, Ph.D.
Senior Investigator
Head, Cell Biology of Genomes Group
Associate Director, CCR Office of Scientific Development

Center for Cancer Research
National Cancer Institute

Building 41, Room B610
Bethesda, MD 20892
301-402-3959

Tom Misteli is an internationally renowned cell biologist who pioneered the use of imaging approaches to study genomes and gene expression. His laboratory uses cell biological, molecular, biochemical and imaging approaches to uncover fundamental principles of genome architecture and to apply this knowledge to the development of novel diagnostic and therapeutic strategies for cancer and aging.

Areas of Expertise
1) chromosomes, 2) chromatin, 3) cell nucleus, 4) nuclear architecture, 5) imaging, 6) epigenetics

Cell Biology of Genomes

My laboratory studies the cell biology of genomes. We use molecular techniques in conjunction with live-cell microscopy to understand how genomes are organized in intact cells and how the spatial organization of genomes contributes to their function. These studies provide insights into basic biological mechanisms and provide the foundation for novel diagnostic and clinical applications in cancer research.

Defects in genome organization and nuclear architecture are responsible for numerous human diseases including cancer, neurodegenerative disorders, and muscular dystrophies and they have recently been linked to human aging. We are using several differentiation and disease models, including embryonic and adult stem cells, to elucidate how genome organization contributes to physiological processes and disease, particularly cancer and aging.

Postdoctoral Fellowships
The Cell Biology of Genomes Group periodically has openings for outstanding postdoctoral fellows. Please send your C.V. and statement of interest to mistelit@mail.nih.gov

Scientific Focus Areas:
Cancer Biology, Cell Biology, Chromosome Biology
  1. Roukos V, Voss TC, Schmidt CK, Lee S, Wangsa D, Misteli T.
    Science. 341: 660-4, 2013. [ Journal Article ]
  2. Luco RF, Pan Q, Tominaga K, Blencowe BJ, Pereira-Smith OM, Misteli T.
    Science. 327: 996-1000, 2010. [ Journal Article ]
  3. Soutoglou E, Dorn JF, Sengupta K, Jasin M, Nussenzweig A, Ried T, Danuser G, Misteli T.
    Nat. Cell Biol. 9: 675-82, 2007. [ Journal Article ]
  4. Scaffidi P, Misteli T.
    Science. 312: 1059-63, 2006. [ Journal Article ]
  5. Phair RD, Misteli T.
    Nature. 404: 604-9, 2000. [ Journal Article ]

Tom Misteli is an internationally renowned pioneer in the field of genome cell biology. He trained at the University of London, UK, and the Cold Spring Harbor Laboratory, NY, where he initiated the use of imaging approaches to study genomes in living cells. His laboratory aims to uncover fundamental principles of higher order genome organization and to apply this knowledge to the development of novel diagnostic and therapeutic strategies for cancer and aging. He has received numerous awards for his work, acts as an advisor for several national and international agencies and serves on numerous editorial boards. He received the Gian Tondury Award, the Gold Medal of The Charles University and the 2012 Flemming Award. He also serves as an Associate Director for the Center for Cancer Research.

Name Position
Rebecca C. Burgess, Ph.D. Research Fellow
Bharat Burman Guest Researcher
Patricia Fernandez Ferri, Ph.D. Research Fellow
Elizabeth Havener Finn, Ph.D. Postdoctoral Fellow
Renee R. Hood, Ph.D. Postdoctoral Fellow (CRTA)
Leonard P. Kubben, Ph.D. Postdoctoral Fellow (Visiting)
Stephen A. Mabon, M.S. Research Biologist
Karen J. Meaburn, Ph.D. Research Fellow (Contr.)
Madaiah Puttaraju, Ph.D. Special Volunteer
Maayan Salton-Morgenstern, Ph.D. Postdoctoral Fellow (Visiting)
Sigal Shachar, Ph.D. Postdoctoral Fellow (Visiting)
Vivek Sharma, Ph.D. Postdoctoral Fellow (Visiting)
Sara K. Snyder, Ph.D. Research Biologist
Linda K. Zane, Ph.D. Postdoctoral Fellow (Visiting)
Sameena Khan, B.S.
Summer Student
(2008 - 2009)

Medical Student
University College Dublin School of Medicine
Dublin, Ireland

Manjari Mazumdar, Ph.D.
Manjari Mazumdar, Ph.D.
Research Fellow
(2003 - 2008)

Assistant Professor
Medical Sciences Program
Indiana University
Bloomington, IN

Takumi Takizawa, M.D., Ph.D.
Takumi Takizawa, M.D., Ph.D.
Research Fellow
(2004 - 2008)

Associate Professor
Graduate School of Medicine
Gunma University
Maebashi, Japan

Reini Fernandez de Luco, Ph.D.
Postdoctoral Fellow
(2007 - 2012)

Group Leader
Institute of Human Molecular Genetics
Montpelier, France

Christine Schmidt, Ph.D.
Christine Schmidt, Ph.D.
Postdoctoral Fellow
(2009 - 2011)

Postdoctoral Fellow
Steve Jackson Lab
The Gurdon Institute
University of Cambridge, UK

Alexandre Mejat, Ph.D.
Postdoctoral Fellow
(2005 - 2009)

Assistant Professor
University of Lyon
Lyon, France

Evi Soutoglou, Ph.D.
Evi Soutoglou, Ph.D.
Postdoctoral Fellow
(2006 - 2008)

Group Leader
Institute for Genetics and Molecular and Cellular Biology
Centre National de la Recherche Scientifique (CNRS)
Strasbourg, France

Michelle Devine, M.S.
Predoctoral Fellow
(2009 - 2010)

Medical Student
University of Texas Southwestern Medical School
Dallas, TX

Nicolas Rascovan, M.S
Predoctoral Fellow
(2008 - 2009)

Ph.D. Student
Rosario National University
Rosario, Argentina

Cordelle Tanega, B.S.
Cordelle Tanega, B.S.
Predoctoral Fellow
(2006 - 2008)

Biologist
Chemical Genomics Center
National Center for Advancing Translational Sciences
National Institutes of Health
Rockville, MD

Karen Baranes-Bachar, M.S.
Special Volunteer
(2009)

Ph.D. Student
Tel Aviv University
Tel Aviv, Israel

Pilar Saladores, B.S.
Postbaccalaureate Fellow
(2008 - 2010)

Ph.D. Student
University of Stuttgart
Stuttgart, Germany

Summary

Tom Misteli is an internationally renowned cell biologist who pioneered the use of imaging approaches to study genomes and gene expression. His laboratory uses cell biological, molecular, biochemical and imaging approaches to uncover fundamental principles of genome architecture and to apply this knowledge to the development of novel diagnostic and therapeutic strategies for cancer and aging.

Areas of Expertise
1) chromosomes, 2) chromatin, 3) cell nucleus, 4) nuclear architecture, 5) imaging, 6) epigenetics

Research

Cell Biology of Genomes

My laboratory studies the cell biology of genomes. We use molecular techniques in conjunction with live-cell microscopy to understand how genomes are organized in intact cells and how the spatial organization of genomes contributes to their function. These studies provide insights into basic biological mechanisms and provide the foundation for novel diagnostic and clinical applications in cancer research.

Defects in genome organization and nuclear architecture are responsible for numerous human diseases including cancer, neurodegenerative disorders, and muscular dystrophies and they have recently been linked to human aging. We are using several differentiation and disease models, including embryonic and adult stem cells, to elucidate how genome organization contributes to physiological processes and disease, particularly cancer and aging.

Postdoctoral Fellowships
The Cell Biology of Genomes Group periodically has openings for outstanding postdoctoral fellows. Please send your C.V. and statement of interest to mistelit@mail.nih.gov

Scientific Focus Areas:
Cancer Biology, Cell Biology, Chromosome Biology

Publications

  1. Roukos V, Voss TC, Schmidt CK, Lee S, Wangsa D, Misteli T.
    Science. 341: 660-4, 2013. [ Journal Article ]
  2. Luco RF, Pan Q, Tominaga K, Blencowe BJ, Pereira-Smith OM, Misteli T.
    Science. 327: 996-1000, 2010. [ Journal Article ]
  3. Soutoglou E, Dorn JF, Sengupta K, Jasin M, Nussenzweig A, Ried T, Danuser G, Misteli T.
    Nat. Cell Biol. 9: 675-82, 2007. [ Journal Article ]
  4. Scaffidi P, Misteli T.
    Science. 312: 1059-63, 2006. [ Journal Article ]
  5. Phair RD, Misteli T.
    Nature. 404: 604-9, 2000. [ Journal Article ]

Biography

Tom Misteli is an internationally renowned pioneer in the field of genome cell biology. He trained at the University of London, UK, and the Cold Spring Harbor Laboratory, NY, where he initiated the use of imaging approaches to study genomes in living cells. His laboratory aims to uncover fundamental principles of higher order genome organization and to apply this knowledge to the development of novel diagnostic and therapeutic strategies for cancer and aging. He has received numerous awards for his work, acts as an advisor for several national and international agencies and serves on numerous editorial boards. He received the Gian Tondury Award, the Gold Medal of The Charles University and the 2012 Flemming Award. He also serves as an Associate Director for the Center for Cancer Research.

Team

Name Position
Rebecca C. Burgess, Ph.D. Research Fellow
Bharat Burman Guest Researcher
Patricia Fernandez Ferri, Ph.D. Research Fellow
Elizabeth Havener Finn, Ph.D. Postdoctoral Fellow
Renee R. Hood, Ph.D. Postdoctoral Fellow (CRTA)
Leonard P. Kubben, Ph.D. Postdoctoral Fellow (Visiting)
Stephen A. Mabon, M.S. Research Biologist
Karen J. Meaburn, Ph.D. Research Fellow (Contr.)
Madaiah Puttaraju, Ph.D. Special Volunteer
Maayan Salton-Morgenstern, Ph.D. Postdoctoral Fellow (Visiting)
Sigal Shachar, Ph.D. Postdoctoral Fellow (Visiting)
Vivek Sharma, Ph.D. Postdoctoral Fellow (Visiting)
Sara K. Snyder, Ph.D. Research Biologist
Linda K. Zane, Ph.D. Postdoctoral Fellow (Visiting)

Alumni

Sameena Khan, B.S.
Summer Student
(2008 - 2009)

Medical Student
University College Dublin School of Medicine
Dublin, Ireland

Manjari Mazumdar, Ph.D.
Manjari Mazumdar, Ph.D.
Research Fellow
(2003 - 2008)

Assistant Professor
Medical Sciences Program
Indiana University
Bloomington, IN

Takumi Takizawa, M.D., Ph.D.
Takumi Takizawa, M.D., Ph.D.
Research Fellow
(2004 - 2008)

Associate Professor
Graduate School of Medicine
Gunma University
Maebashi, Japan

Reini Fernandez de Luco, Ph.D.
Postdoctoral Fellow
(2007 - 2012)

Group Leader
Institute of Human Molecular Genetics
Montpelier, France

Christine Schmidt, Ph.D.
Christine Schmidt, Ph.D.
Postdoctoral Fellow
(2009 - 2011)

Postdoctoral Fellow
Steve Jackson Lab
The Gurdon Institute
University of Cambridge, UK

Alexandre Mejat, Ph.D.
Postdoctoral Fellow
(2005 - 2009)

Assistant Professor
University of Lyon
Lyon, France

Evi Soutoglou, Ph.D.
Evi Soutoglou, Ph.D.
Postdoctoral Fellow
(2006 - 2008)

Group Leader
Institute for Genetics and Molecular and Cellular Biology
Centre National de la Recherche Scientifique (CNRS)
Strasbourg, France

Michelle Devine, M.S.
Predoctoral Fellow
(2009 - 2010)

Medical Student
University of Texas Southwestern Medical School
Dallas, TX

Nicolas Rascovan, M.S
Predoctoral Fellow
(2008 - 2009)

Ph.D. Student
Rosario National University
Rosario, Argentina

Cordelle Tanega, B.S.
Cordelle Tanega, B.S.
Predoctoral Fellow
(2006 - 2008)

Biologist
Chemical Genomics Center
National Center for Advancing Translational Sciences
National Institutes of Health
Rockville, MD

Karen Baranes-Bachar, M.S.
Special Volunteer
(2009)

Ph.D. Student
Tel Aviv University
Tel Aviv, Israel

Pilar Saladores, B.S.
Postbaccalaureate Fellow
(2008 - 2010)

Ph.D. Student
University of Stuttgart
Stuttgart, Germany

Resources