Tom  Misteli, Ph.D.
Tom Misteli, Ph.D.
Senior Investigator
Head, Cell Biology of Genomes Group

Center for Cancer Research
National Cancer Institute

Building 41, Room B610
Bethesda, MD 20892
301-402-3959

Tom Misteli is an internationally renowned cell biologist who pioneered the use of imaging approaches to study genomes and gene expression. His laboratory uses cell biological, molecular, biochemical and imaging approaches to uncover fundamental principles of genome architecture and to apply this knowledge to the development of novel diagnostic and therapeutic strategies for cancer and aging.

Areas of Expertise
1) Chromosomes 2) Chromatin 3) Cell Nucleus 4) Nuclear Architecture 5) Imaging 6) Epigenetics

Cell Biology of Genomes

My laboratory studies the cell biology of genomes. We use molecular techniques in conjunction with live-cell microscopy to understand how genomes are organized in intact cells and how the spatial organization of genomes contributes to their function. These studies provide insights into basic biological mechanisms and provide the foundation for novel diagnostic and clinical applications in cancer research.

Defects in genome organization and nuclear architecture are responsible for numerous human diseases including cancer, neurodegenerative disorders, and muscular dystrophies and they have recently been linked to human aging. We are using several differentiation and disease models, including embryonic and adult stem cells, to elucidate how genome organization contributes to physiological processes and disease, particularly cancer and aging.

Scientific Focus Areas:
Cancer Biology, Cell Biology, Chromosome Biology
Selected Key Publications
  1. Roukos V, Voss TC, Schmidt CK, Lee S, Wangsa D, Misteli T.
    Science. 341: 660-4, 2013. [ Journal Article ]
  2. Luco RF, Pan Q, Tominaga K, Blencowe BJ, Pereira-Smith OM, Misteli T.
    Science. 327: 996-1000, 2010. [ Journal Article ]
  3. Soutoglou E, Dorn JF, Sengupta K, Jasin M, Nussenzweig A, Ried T, Danuser G, Misteli T.
    Nat. Cell Biol. 9: 675-82, 2007. [ Journal Article ]
  4. Scaffidi P, Misteli T.
    Science. 312: 1059-63, 2006. [ Journal Article ]
  5. Phair RD, Misteli T.
    Nature. 404: 604-9, 2000. [ Journal Article ]

Tom Misteli is an internationally renowned pioneer in the field of genome cell biology. He trained at the University of London, UK, and the Cold Spring Harbor Laboratory, NY, where he initiated the use of imaging approaches to study genomes in living cells. His laboratory aims to uncover fundamental principles of higher order genome organization and to apply this knowledge to the development of novel diagnostic and therapeutic strategies for cancer and aging. He has received numerous awards for his work, acts as an advisor for several national and international agencies and serves on numerous editorial boards. He received the Gian Tondury Award, the Gold Medal of The Charles University and the 2012 Flemming Award. He also serves as an Associate Director for the Center for Cancer Research.

Name Position
Rebecca C. Burgess Ph.D. Research Fellow
Bharat Burman Guest Researcher
Megan Donegan Special Volunteer
Patricia Fernandez Ferri Ph.D. Research Fellow
Elizabeth Finn Ph.D. Postdoctoral Fellow
Leonard (Nard) P. Kubben Ph.D. Postdoctoral Fellow (Visiting)
Steve Mabon MS Research Biologist
Karen Meaburn Ph.D. Research Fellow (Contr.)
Madaiah Puttaraju Ph.D. Special Volunteer
Vasileios Roukos Ph.D Postdoctoral Fellow (Visiting)
Maayan Salton-Morgenstern Ph.D. Postdoctoral Fellow (Visiting)
Sigal Shachar Ph.D. Postdoctoral Fellow (Visiting)
Vivek Sharma Ph.D. Postdoctoral Fellow (Visiting)
Sara Snyder Ph.D. Research Biologist
Linda Karine Zane Ph.D. Postdoctoral Fellow (Visiting)

Summary

Tom Misteli is an internationally renowned cell biologist who pioneered the use of imaging approaches to study genomes and gene expression. His laboratory uses cell biological, molecular, biochemical and imaging approaches to uncover fundamental principles of genome architecture and to apply this knowledge to the development of novel diagnostic and therapeutic strategies for cancer and aging.

Areas of Expertise
1) Chromosomes 2) Chromatin 3) Cell Nucleus 4) Nuclear Architecture 5) Imaging 6) Epigenetics

Research

Cell Biology of Genomes

My laboratory studies the cell biology of genomes. We use molecular techniques in conjunction with live-cell microscopy to understand how genomes are organized in intact cells and how the spatial organization of genomes contributes to their function. These studies provide insights into basic biological mechanisms and provide the foundation for novel diagnostic and clinical applications in cancer research.

Defects in genome organization and nuclear architecture are responsible for numerous human diseases including cancer, neurodegenerative disorders, and muscular dystrophies and they have recently been linked to human aging. We are using several differentiation and disease models, including embryonic and adult stem cells, to elucidate how genome organization contributes to physiological processes and disease, particularly cancer and aging.

Scientific Focus Areas:
Cancer Biology, Cell Biology, Chromosome Biology

Publications

Selected Key Publications
  1. Roukos V, Voss TC, Schmidt CK, Lee S, Wangsa D, Misteli T.
    Science. 341: 660-4, 2013. [ Journal Article ]
  2. Luco RF, Pan Q, Tominaga K, Blencowe BJ, Pereira-Smith OM, Misteli T.
    Science. 327: 996-1000, 2010. [ Journal Article ]
  3. Soutoglou E, Dorn JF, Sengupta K, Jasin M, Nussenzweig A, Ried T, Danuser G, Misteli T.
    Nat. Cell Biol. 9: 675-82, 2007. [ Journal Article ]
  4. Scaffidi P, Misteli T.
    Science. 312: 1059-63, 2006. [ Journal Article ]
  5. Phair RD, Misteli T.
    Nature. 404: 604-9, 2000. [ Journal Article ]

Biography

Tom Misteli is an internationally renowned pioneer in the field of genome cell biology. He trained at the University of London, UK, and the Cold Spring Harbor Laboratory, NY, where he initiated the use of imaging approaches to study genomes in living cells. His laboratory aims to uncover fundamental principles of higher order genome organization and to apply this knowledge to the development of novel diagnostic and therapeutic strategies for cancer and aging. He has received numerous awards for his work, acts as an advisor for several national and international agencies and serves on numerous editorial boards. He received the Gian Tondury Award, the Gold Medal of The Charles University and the 2012 Flemming Award. He also serves as an Associate Director for the Center for Cancer Research.

Team

Name Position
Rebecca C. Burgess Ph.D. Research Fellow
Bharat Burman Guest Researcher
Megan Donegan Special Volunteer
Patricia Fernandez Ferri Ph.D. Research Fellow
Elizabeth Finn Ph.D. Postdoctoral Fellow
Leonard (Nard) P. Kubben Ph.D. Postdoctoral Fellow (Visiting)
Steve Mabon MS Research Biologist
Karen Meaburn Ph.D. Research Fellow (Contr.)
Madaiah Puttaraju Ph.D. Special Volunteer
Vasileios Roukos Ph.D Postdoctoral Fellow (Visiting)
Maayan Salton-Morgenstern Ph.D. Postdoctoral Fellow (Visiting)
Sigal Shachar Ph.D. Postdoctoral Fellow (Visiting)
Vivek Sharma Ph.D. Postdoctoral Fellow (Visiting)
Sara Snyder Ph.D. Research Biologist
Linda Karine Zane Ph.D. Postdoctoral Fellow (Visiting)