Liver Carcinogenesis Section

Xin Wei Wang, Ph.D.


Amanda Craig, Ph.D.
Amanda Craig, Ph.D.
Sophia Heinrich, M.D., Ph.D.
Sophia Heinrich, M.D., Ph.D.
Julian Candia, Ph.D.
staff scientist
Eun Ju Cho, M.D.
visiting fellow
Yotsawat Pomyen, Ph.D.
postdoctoral fellow
Maria Olga Hernandez, Ph.D.
Research Fellow
Dana Dominguez, M.D.
Clinical Fellow
Sean Martin, DO
Clinical Fellow
Jinping Liu, Ph.D.
Postdoctoral Fellow
Na Zhao, Ph.D.
Postdoctoral Fellow
Valerie Fako Miller, Ph.D.
Postdoctoral Fellow
Enkhjargal Bayarsaikhan, M.D.
Visiting Fellow


Cancer Cell Cover - Oct 14, 2019; Volume 36, Issue 4, p418-430

Tumor Cell Biodiversity Drives Microenvironmental Reprogramming in Liver Cancer

Published Date

On the cover:  Liver cancers are molecularly and biologically heterogenous, which contributes to their therapeutic failures and lethal outcomes. Ma et al. (pp. 418–430) have developed a single-cell-based approach to determine tumor cell communities (depicted as dice emptying out of a jar) and uncover a unique liver cancer ecosystem relevant to immune therapy. A tumor cell community is depicted by dice with different colors and shapes, where color represents cell type and shape represents unique molecular properties. Artwork by Ethan Tyler.


Ma L, Hernandez MO, Zhao Y, Mehta M, Tran B, Kelly M, Rae Z, Hernandez JM, Davis JL, Martin SP, Kleiner DE, Hewitt SM, Ylaya K, Wood BJ, Greten TF, Wang XW. Tumor cell biodiversity drives microenvironmental reprogramming in liver cancer. Cancer Cell 36(4): 418-30, 2019; PMID: 31588021. 

Cancer Cell Cover - Jul 10, 2017; Volume 32, Issue 1, p1-128

TIGER-LC Consortium. Common Molecular Subtypes Among Asian Hepatocellular Carcinoma and Cholangiocarcinoma

Published Date

On the cover: The Thailand Initiative in Genomics and Expression Research for Liver Cancer (TIGER-LC) Consortium (depicted as a tiger) emerges from foliage, representing molecular, clinical, and epidemiological studies from teams in the United States, Thailand, and Japan, to generate a multilayered genomic and genetic liver cancer data ecosystem (represented by the tiger’s tail). Although common molecular subtypes (depicted as bamboo stalks) are observed among liver cancer types, there are differences observed between Asian and Caucasian populations (depicted by different bamboo colors). For more details, see Chaisaingmongkol et al. (pp. 57–70). Cover art by Ethan Tyler.


Chaisaingmongkol J, Budhu A, Dang H, Rabibhadana S, Pupacdi B, Kwon SM, Forgues M, Bhudhisawasdi V, Lertprasertsuke N, Chotirosniramit A, Pairojkul C, Auewarakul CU, Sricharunrat T, Phornphutkul K, Sangrajrang S, Cam M, He P, Hewitt SM, Ylaya K, Wu X, Andersen JB, Thorgeirsson SS, Waterfall JJ, Zhu YJ, Walling J, Stevenson HS, Meltzer PS, Loffredo CA, Hama N, Shibata T, Wiltrout RH, Harris CC, Mahidol C, Ruchirawat M, Wang XW. Common molecular subtypes among Asian hepatocellular and cholangiocarcinoma. Cancer Cell 32(1): 57-70.e3, 2017; PMID: 28648284