Breadcrumb

CCR Director Tom Misteli, Ph.D.

Tom Misteli, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute

RESEARCH SUMMARY

Tom Misteli is an internationally renowned cell biologist who pioneered the use of imaging approaches to study genomes and gene expression. His laboratory uses cell biological, molecular, biochemical and imaging approaches to uncover fundamental principles of genome architecture and to apply this knowledge to the development of novel diagnostic and therapeutic strategies for cancer and aging.

Areas of Expertise

1) chromosomes 2) chromatin 3) cell nucleus 4) nuclear architecture 5) imaging 6) epigenetics

Research

Cell Biology of Genomes

My laboratory studies the cell biology of genomes. We use molecular techniques in conjunction with live-cell microscopy to understand how genomes are organized in intact cells and how the spatial organization of genomes contributes to their function. These studies provide insights into basic biological mechanisms and establish the foundation for novel diagnostic and clinical applications in cancer research.

Defects in genome organization and nuclear architecture are responsible for numerous human diseases including cancer, neurodegenerative disorders, and muscular dystrophies and they have been linked to human aging. We are using several differentiation and disease models to elucidate how genome organization contributes to physiological processes and disease, particularly in cancer and aging.

Postdoctoral Fellowships

The Cell Biology of Genomes Group has an opening for an outstanding postdoctoral fellow to explore synthetic biology and bioengineering approaches to genome organization. Please send your C.V. and statement of interest to mistelit@mail.nih.gov

Summer Students

This year's summer internship positions have been filled. Thank you for your interest in our work.

NIH Scientific Focus Areas
Cancer Biology
Chromosome Biology
Molecular Biology and Biochemistry
RNA Biology

Publications

Selected Key Publications

Extensive Heterogeneity and Intrinsic Variation in Spatial Genome Organization.

Finn EH, Pegoraro G, Brandão HB, Valton AL, Oomen ME, Dekker J, Mirny L, Misteli T.
Cell. 176: 1501-1515, 2019. [ Journal Article ]

Repression of the Antioxidant NRF2 Pathway in Premature Aging

Kubben N, Zhang W, Wang L, Voss TC, Yang J, Qu J, Liu GH, Misteli T
Cell. 165: 1361-1374, 2016. [ Journal Article ]

Identification of gene positioning factors using high-throughput imaging mapping

Shachar S, Voss TC, Pegoraro G, Sciascia N, Misteli T.
Cell. 162(4): 911-23, 2015. [ Journal Article ]

Spatial dynamics of chromosome translocations in living cells

Roukos V, Voss TC, Schmidt CK, Lee S, Wangsa D, Misteli T.
Science. 341: 660-4, 2013. [ Journal Article ]

Regulation of alternative splicing by histone modifications

Luco RF, Pan Q, Tominaga K, Blencowe BJ, Pereira-Smith OM, Misteli T.
Science. 327: 996-1000, 2010. [ Journal Article ]

Alumni

Leonard Kubben, Ph.D.
Leonard Kubben, Ph.D.
2008-2018
Research Fellow
Reini Fernandez de Luco, Ph.D.
Reini Fernandez de Luco, Ph.D.
(2007 - 2012)
Postdoctoral Fellow
Christine Schmidt, Ph.D.
Christine Schmidt, Ph.D.
(2009 - 2011)
Postdoctoral Fellow
Pilar Saladores, B.S.
Pilar Saladores, B.S.
(2008 - 2010)
Postbaccalaureate Fellow
Alexandre Mejat, Ph.D.
Alexandre Mejat, Ph.D.
(2005 - 2009)
Postdoctoral Fellow
Nicolas Rascovan, M.S
Nicolas Rascovan, M.S
(2008 - 2009)
Predoctoral Fellow
Karen Baranes-Bachar, M.S.
Karen Baranes-Bachar, M.S.
(2009)
Special Volunteer
Sameena Khan, B.S.
Sameena Khan, B.S.
(2008 - 2009)
Summer Student
Manjari Mazumdar, Ph.D.
Manjari Mazumdar, Ph.D.
(2003 - 2008)
Research Fellow
Michelle Devine, M.S.
Michelle Devine, M.S.
(2009 - 2010)
Predoctoral Fellow
Takumi Takizawa, M.D., Ph.D.
Takumi Takizawa, M.D., Ph.D.
(2004 - 2008)
Research Fellow
Evi Soutoglou, Ph.D.
Evi Soutoglou, Ph.D.
(2006 - 2008)
Postdoctoral Fellow
Cordelle Tanega, B.S.
Cordelle Tanega, B.S.
(2006 - 2008)
Predoctoral Fellow