David S. Schrump, M.D., M.B.A., FACS

David S. Schrump, M.D., M.B.A., FACS

  • Center for Cancer Research
  • National Cancer Institute


As Surgical Chief of the Branch, Dr. Schrump oversees clinical and translational research pertaining to thoracic malignancies, including the development of innovative molecular approaches to the diagnosis and treatment of these neoplasms. He has pioneered the development of epigenomic therapies for thoracic cancers. Using unique in vitro models and correlative experiments with surgical specimens, he has characterized epigenetic responses to tobacco carcinogens, and identified novel therapeutic targets in lung and esophageal cancers and pleural mesotheliomas. His clinical protocols have demonstrated that chromatin remodeling agents simultaneously induce growth arrest and augment immunogenicity of thoracic malignancies; these efforts have provided rationale for combining epigenetic regimens with immunotherapies for these neoplasms.

Areas of Expertise

Thoracic Surgery
Cancer Epigenetics
Esophageal Cancer

Information for Patients

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Clinical Trials


Selected Key Publications

Recognition of galactosylgloboside by monoclonal antibodies derived from patients with primary lung cancer.

Schrump DS, Furukawa K, Yamaguchi H, Lloyd KO, Old LJ
Proc Natl Acad Sci U S A. 85(12): 4441-5, 1988. [ Journal Article ]

Bile acid-induced "Minority MOMP" promotes esophageal carcinogenesis while maintaining apoptotic resistance via Mcl-1

Xu Y, Surman DR, Diggs L, Xi S, Gao S, Gurusamy D, McLoughlin K, Drake J, Feingold P, Brown K, Wangsa D, Wangsa D, Zhang X, Ried T, Davis JL, Hernandez J, Hoang CD, Souza RF, Schrump DS, Taylor Ripley R.
Oncogene. 39(4): 877-90, 2020. [ Journal Article ]

ASXL3 Is a Novel Pluripotency Factor in Human Respiratory Epithelial Cells and a Potential Therapeutic Target in Small Cell Lung Cancer

Shukla V, Rao M, Zhang H, Beers J, Wangsa D, Wangsa D, Buishand FO, Wang Y, Yu Z, Stevenson HS, Reardon ES, McLoughlin KC, Kaufman AS, Payabyab EC, Hong JA, Zhang M, Davis S, Edelman D, Chen G, Miettinen MM, Restifo NP, Ried T, Meltzer PA, Schrump DS.
Cancer Res. 77(22): 6267-81, 2017. [ Journal Article ]

Mithramycin represses basal and cigarette smoke-induced expression of ABCG2 and inhibits stem cell signaling in lung and esophageal cancer cells

Zhang M, Mathur A, Zhang Y, Xi S, Atay S, Hong JA, Datrice N, Upham T, Kemp CD, Ripley RT, Wiegand G, Avital I, Fetsch P, Mani H, Zlott D, Li X, Rao M, Schrump DS
Cancer Res. 72(16): 4178-92, 2013. [ Journal Article ]

Immunologic Recognition of a Shared p53 Mutated Neoantigen in a Patient with Metastatic Colorectal Cancer

Lo W, Parkhurst M, Robbins PF, Tran E, Lu YC, Jia L, Gartner JJ, Pasetto A, Deniger D, Malekzadeh P, Shelton TE, Prickett T, Ray S, Kivitz S, Paria BC, Kriley I, Schrump DS, Rosenberg SA.
Cancer Immunol Res. 7(4): 534-43, 2019. [ Journal Article ]

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Jan Pappas
Program Specialist
Jan Pappas
Postdoctoral Fellow (Visiting)
Tuana Tolunay, M.D.
Bioinformatics Specialist (Contr.)
Haitao Wang, Ph.D.
Staff Scientist
Ruihong Wang, Ph.D.
Research Biologist
Sichuan Xi, M.D., Ph.D.
Research Biologist
Mary Zhang, Ph.D.
Postdoctoral Fellow (Visiting)
Xinwei Wu, M.D., Ph.D.
Research Biologist
Stephanie Shiffka, Ph.D.
Postdoctoral Fellow (Visiting)
Keerti Mishra, Ph.D.
Senior Research Nurse Specialist
Deneise Francis, BSN, RN, OCN, CCRP
Physician's Assistant
Amanda Absher, MPAS, PA-C
Patient Care Coordinator
Shirrita Ferguson