Andrew M. Blakely, M.D.
- Center for Cancer Research
- National Cancer Institute
- Building 10, Room 4-3760
- Bethesda, MD 20892
Dr. Blakely is a surgical oncologist specializing in peritoneal surface malignancies and soft tissue sarcomas. Primary focuses of his research include:
1) Improving surgical treatment and ex vivo tumor modeling of gastrointestinal stromal tumors
2) Validating ex vivo peritoneal tumor treatment models in the pursuit of personalized HIPEC
3) Developing novel treatment approaches to mucinous and non-mucinous peritoneal carcinomatosis
Areas of Expertise
1) peritoneal carcinomatosis from colorectal, appendiceal, ovarian, and other histologies 2) peritoneal mesothelioma 3) soft tissue sarcomas including gastrointestinal stromal tumors 4) gastroenteropancreatic neuroendocrine tumors
Information for Patients
Learn more about our clinical trials and the highly specialized care teams that lead them.
Peritoneal malignancies may arise from various organs, including but not limited to the colon, appendix, stomach, ovary, or adrenal gland. However, peritoneal tumor deposits tend to be relatively resistant to traditional intravenous systemic chemotherapy regimens that are otherwise effective for disease involving other sites, such as the liver or lungs. Administration of intraperitoneal chemotherapy allows much higher chemotherapeutic drug levels to be achieved in the peritoneal cavity, with far less systemic absorption and toxicity than if given intravenously at the same dose. However, intraperitoneal chemotherapy is only effective after cytoreductive surgery, where all disease >2.5 mm has been completely removed or ablated. Unfortunately, many patients with peritoneal carcinomatosis have high burdens of disease, which may preclude optimal cytoreduction or lead to such debilitation that extensive surgical resection would not be tolerated by the patient.
Dr. Blakely’s research primarily focuses on developing treatment strategies that bring the potential benefits of pre-operative therapy to patients with peritoneal surface malignancies. Neoadjuvant intraperitoneal chemotherapy administration may reduce peritoneal surface disease burden, which in turn facilitates or even obviates subsequent cytoreductive surgery. In addition, for patients experiencing symptomatic malignant ascites, intraperitoneal chemotherapy alone can effectively palliate unresectable patients.
A Collaborative Surgical Approach to Upper and Lower Abdominal Cytoreductive Surgery in Ovarian Cancer
American College of Surgeons National Surgical Quality Improvement Program as a Quality-Measurement Tool for Advanced Cancer Patients
Andrew M. Blakely, M.D.
Dr. Blakely completed a Bachelor of Science in Biomedical Engineering followed by medical school at Drexel University. He went on to general surgery residency at Brown University. During residency, he spent two years of dedicated research time at the Center for Biomedical Engineering developing a device for tissue engineering applications. That work then led to a National Science Foundation grant and a patent. Dr. Blakely then completed his fellowship in Complex General Surgical Oncology at City of Hope National Medical Center.