Tom Misteli is an internationally renowned cell biologist who pioneered the use of imaging approaches to study genomes and gene expression. His laboratory uses cell biological, molecular, biochemical and imaging approaches to uncover fundamental principles of genome architecture and to apply this knowledge to the development of novel diagnostic and therapeutic strategies for cancer and aging.
1) chromosomes, 2) chromatin, 3) cell nucleus, 4) nuclear architecture, 5) imaging, 6) epigenetics
Cell Biology of Genomes
My laboratory studies the cell biology of genomes. We use molecular techniques in conjunction with live-cell microscopy to understand how genomes are organized in intact cells and how the spatial organization of genomes contributes to their function. These studies provide insights into basic biological mechanisms and establish the foundation for novel diagnostic and clinical applications in cancer research.
Defects in genome organization and nuclear architecture are responsible for numerous human diseases including cancer, neurodegenerative disorders, and muscular dystrophies and they have been linked to human aging. We are using several differentiation and disease models to elucidate how genome organization contributes to physiological processes and disease, particularly in cancer and aging.
Postdoctoral Fellowships
The Cell Biology of Genomes Group has an opening for an outstanding postdoctoral fellow to explore synthetic biology and bioengineering approaches to genome organization. Please send your C.V. and statement of interest to mistelit@mail.nih.gov
Summer Students
This year's summer internship positions have been filled. Thank you for your interest in our work.
Selected Key Publications
Tom Misteli is an internationally renowned pioneer in the field of genome cell biology. He trained at the University of London, UK, and the Cold Spring Harbor Laboratory, NY, where he initiated the use of imaging approaches to study genomes in living cells. His laboratory aims to uncover fundamental principles of higher order genome organization and to apply this knowledge to the development of novel diagnostic and therapeutic strategies for cancer and aging. He has received numerous awards for his work, acts as an advisor for several national and international agencies and serves on numerous editorial boards. He has received numerous awards including the Gian Tondury Award, the Gold Medal of The Charles University, the 2012 Flemming Award, The Wilhem Bernhard Medal and the Herman Beerman Award.
| Position | Degree Required | Contact Name | E-mail Address |
|---|---|---|---|
| Chief - Laboratory of Cancer Biology and Genetics - cancer biology, tumorigenesis, metastasis, pathogenesis | Ph.D. or equivalent, M.D. or equivalent | Lori Holliday | hollidal@mail.nih.gov |
| Name | Position |
|---|---|
| Faisal Almansour M.S. | Predoctoral Visiting Fellow (Graduate Student) |
| Elizabeth Finn Ph.D. | Postdoctoral Fellow (CRTA) |
| Kelsey Gallant B.S. | Postbaccalaureate Fellow (CRTA) |
| Arturo Garza-Gongora Ph.D. | Postdoctoral Fellow (CRTA) |
| Steve Mabon M.S. | Research Biologist |
| Marina Mahynski Ph.D. | Postdoctoral Fellow (CRTA) |
| Yasmine Mian B.S. | Postbaccalaureate Fellow (CRTA) |
| Madaiah Puttaraju Ph.D. | Research Fellow |
| Isabel Quintanilla Leo Ph.D. | Postdoctoral Fellow (CRTA) |
| Andria Schibler Ph.D. | Postdoctoral Fellow (CRTA) |
| Asaf Shilo Ph.D. | Postdoctoral Fellow (Visiting) |
| Varun Sood Ph.D. | Postdoctoral Fellow (Visiting) |
| Sandra Vidak Ph.D. | Postdoctoral Fellow (Visiting) |
Group Leader
Institute of Human Molecular Genetics
Montpelier, France
Postdoctoral Fellow
Steve Jackson Lab
The Gurdon Institute
University of Cambridge, UK
Ph.D. Student
University of Stuttgart
Stuttgart, Germany
Assistant Professor
University of Lyon
Lyon, France
Ph.D. Student
Rosario National University
Rosario, Argentina
Ph.D. Student
Tel Aviv University
Tel Aviv, Israel
Medical Student
University College Dublin School of Medicine
Dublin, Ireland
Assistant Professor
Medical Sciences Program
Indiana University
Bloomington, IN
Associate Professor
Graduate School of Medicine
Gunma University
Maebashi, Japan
Medical Student
University of Texas Southwestern Medical School
Dallas, TX
Group Leader
Institute for Genetics and Molecular and Cellular Biology
Centre National de la Recherche Scientifique (CNRS)
Strasbourg, France
Biologist
Chemical Genomics Center
National Center for Advancing Translational Sciences
National Institutes of Health
Rockville, MD
Immunofluorescence
GFP Visualization
Immunodetection of Transcription Sites
Preparing Nuclear Matrix
Generating Probes for RNA FISH
RNA FISH
DNA FISH
Preparing Chromosome Spreads
G-Banding of Chromosomes
Chromosome Painting
Cell Biology of Genomes
My laboratory studies the cell biology of genomes. We use molecular techniques in conjunction with live-cell microscopy to understand how genomes are organized in intact cells and how the spatial organization of genomes contributes to their function. These studies provide insights into basic biological mechanisms and establish the foundation for novel diagnostic and clinical applications in cancer research.
Defects in genome organization and nuclear architecture are responsible for numerous human diseases including cancer, neurodegenerative disorders, and muscular dystrophies and they have been linked to human aging. We are using several differentiation and disease models to elucidate how genome organization contributes to physiological processes and disease, particularly in cancer and aging.
Postdoctoral Fellowships
The Cell Biology of Genomes Group has an opening for an outstanding postdoctoral fellow to explore synthetic biology and bioengineering approaches to genome organization. Please send your C.V. and statement of interest to mistelit@mail.nih.gov
Summer Students
This year's summer internship positions have been filled. Thank you for your interest in our work.
Selected Key Publications
Tom Misteli is an internationally renowned pioneer in the field of genome cell biology. He trained at the University of London, UK, and the Cold Spring Harbor Laboratory, NY, where he initiated the use of imaging approaches to study genomes in living cells. His laboratory aims to uncover fundamental principles of higher order genome organization and to apply this knowledge to the development of novel diagnostic and therapeutic strategies for cancer and aging. He has received numerous awards for his work, acts as an advisor for several national and international agencies and serves on numerous editorial boards. He has received numerous awards including the Gian Tondury Award, the Gold Medal of The Charles University, the 2012 Flemming Award, The Wilhem Bernhard Medal and the Herman Beerman Award.
| Position | Degree Required | Contact Name | E-mail Address |
|---|---|---|---|
| Chief - Laboratory of Cancer Biology and Genetics - cancer biology, tumorigenesis, metastasis, pathogenesis | Ph.D. or equivalent, M.D. or equivalent | Lori Holliday | hollidal@mail.nih.gov |
| Name | Position |
|---|---|
| Faisal Almansour M.S. | Predoctoral Visiting Fellow (Graduate Student) |
| Elizabeth Finn Ph.D. | Postdoctoral Fellow (CRTA) |
| Kelsey Gallant B.S. | Postbaccalaureate Fellow (CRTA) |
| Arturo Garza-Gongora Ph.D. | Postdoctoral Fellow (CRTA) |
| Steve Mabon M.S. | Research Biologist |
| Marina Mahynski Ph.D. | Postdoctoral Fellow (CRTA) |
| Yasmine Mian B.S. | Postbaccalaureate Fellow (CRTA) |
| Madaiah Puttaraju Ph.D. | Research Fellow |
| Isabel Quintanilla Leo Ph.D. | Postdoctoral Fellow (CRTA) |
| Andria Schibler Ph.D. | Postdoctoral Fellow (CRTA) |
| Asaf Shilo Ph.D. | Postdoctoral Fellow (Visiting) |
| Varun Sood Ph.D. | Postdoctoral Fellow (Visiting) |
| Sandra Vidak Ph.D. | Postdoctoral Fellow (Visiting) |
Group Leader
Institute of Human Molecular Genetics
Montpelier, France
Postdoctoral Fellow
Steve Jackson Lab
The Gurdon Institute
University of Cambridge, UK
Ph.D. Student
University of Stuttgart
Stuttgart, Germany
Assistant Professor
University of Lyon
Lyon, France
Ph.D. Student
Rosario National University
Rosario, Argentina
Ph.D. Student
Tel Aviv University
Tel Aviv, Israel
Medical Student
University College Dublin School of Medicine
Dublin, Ireland
Assistant Professor
Medical Sciences Program
Indiana University
Bloomington, IN
Associate Professor
Graduate School of Medicine
Gunma University
Maebashi, Japan
Medical Student
University of Texas Southwestern Medical School
Dallas, TX
Group Leader
Institute for Genetics and Molecular and Cellular Biology
Centre National de la Recherche Scientifique (CNRS)
Strasbourg, France
Biologist
Chemical Genomics Center
National Center for Advancing Translational Sciences
National Institutes of Health
Rockville, MD
Immunofluorescence
GFP Visualization
Immunodetection of Transcription Sites
Preparing Nuclear Matrix
Generating Probes for RNA FISH
RNA FISH
DNA FISH
Preparing Chromosome Spreads
G-Banding of Chromosomes
Chromosome Painting
