Cell Biology of Genomes
My laboratory studies the cell biology of genomes. We use molecular techniques in conjunction with live-cell microscopy to understand how genomes are organized in intact cells and how the spatial organization of genomes contributes to their function. These studies provide insights into basic biological mechanisms and establish the foundation for novel diagnostic and clinical applications in cancer research.
Defects in genome organization and nuclear architecture are responsible for numerous human diseases including cancer, neurodegenerative disorders, and muscular dystrophies and they have been linked to human aging. We are using several differentiation and disease models to elucidate how genome organization contributes to physiological processes and disease, particularly in cancer and aging.
Postdoctoral Fellowships
The Cell Biology of Genomes Group has an opening for an outstanding postdoctoral fellow to explore synthetic biology and bioengineering approaches to genome organization. Please send your C.V. and statement of interest to mistelit@mail.nih.gov
Summer Students
This year's summer internship positions have been filled. Thank you for your interest in our work.