Tom Misteli, Ph.D.

Tom Misteli, Ph.D.

Director, Center for Cancer Research

Laboratory of Receptor Biology and Gene Expression
NIH Distinguished Investigator
Head, Cell Biology of Genomes Group

Tom Misteli is an internationally renowned cell biologist who pioneered the use of imaging approaches to study genomes and gene expression. His laboratory uses cell biological, molecular, biochemical and imaging approaches to uncover fundamental principles of genome architecture and to apply this knowledge to the development of novel diagnostic and therapeutic strategies for cancer and aging.

Areas of Expertise
1) chromosomes, 2) chromatin, 3) cell nucleus, 4) nuclear architecture, 5) imaging, 6) epigenetics

Contact Info

Tom Misteli, Ph.D.
Center for Cancer Research
National Cancer Institute
Building 41, Room B610
Bethesda, MD 20892
Ph: 240-760-6669
mistelit@mail.nih.gov
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Cell Biology of Genomes

My laboratory studies the cell biology of genomes. We use molecular techniques in conjunction with live-cell microscopy to understand how genomes are organized in intact cells and how the spatial organization of genomes contributes to their function. These studies provide insights into basic biological mechanisms and provide the foundation for novel diagnostic and clinical applications in cancer research.

Defects in genome organization and nuclear architecture are responsible for numerous human diseases including cancer, neurodegenerative disorders, and muscular dystrophies and they have recently been linked to human aging. We are using several differentiation and disease models, including embryonic and adult stem cells, to elucidate how genome organization contributes to physiological processes and disease, particularly cancer and aging.

Postdoctoral Fellowships
The Cell Biology of Genomes Group periodically has openings for outstanding postdoctoral fellows. Please send your C.V. and statement of interest to mistelit@mail.nih.gov

Scientific Focus Areas:
Cancer Biology, Chromosome Biology, Molecular Biology and Biochemistry
View Dr. Misteli's PubMed Summary.

Selected Key Publications

  1. Identification of gene positioning factors using high-throughput imaging mapping.
    Shachar S, Voss TC, Pegoraro G, Sciascia N, Misteli T.
    Cell. 162(4): 911-23, 2015. [ Journal Article ]
  2. Spatial dynamics of chromosome translocations in living cells.
    Roukos V, Voss TC, Schmidt CK, Lee S, Wangsa D, Misteli T.
    Science. 341: 660-4, 2013. [ Journal Article ]
  3. Regulation of alternative splicing by histone modifications.
    Luco RF, Pan Q, Tominaga K, Blencowe BJ, Pereira-Smith OM, Misteli T.
    Science. 327: 996-1000, 2010. [ Journal Article ]
  4. Lamin A-dependent nuclear defects in human aging.
    Scaffidi P, Misteli T.
    Science. 312: 1059-63, 2006. [ Journal Article ]
  5. High mobility of proteins in the mammalian cell nucleus.
    Phair RD, Misteli T.
    Nature. 404: 604-9, 2000. [ Journal Article ]

Tom Misteli is an internationally renowned pioneer in the field of genome cell biology. He trained at the University of London, UK, and the Cold Spring Harbor Laboratory, NY, where he initiated the use of imaging approaches to study genomes in living cells. His laboratory aims to uncover fundamental principles of higher order genome organization and to apply this knowledge to the development of novel diagnostic and therapeutic strategies for cancer and aging. He has received numerous awards for his work, acts as an advisor for several national and international agencies and serves on numerous editorial boards. He has received numerous awards including the Gian Tondury Award, the Gold Medal of The Charles University, the 2012 Flemming Award, The Wilhem Bernhard Medal and the Herman Beerman Award.

Name Position
Hesam Babahosseini Ph.D. Postdoctoral Fellow (Visiting)
Emily DeBoy Special Volunteer
Marina Feric Ph.D. Postdoctoral Fellow (CRTA)
Elizabeth Finn Ph.D. Postdoctoral Fellow (CRTA)
Predrag Jevtic Ph.D. Research Collaborator
Ziad Jowhar B.S. Postbaccalaureate Fellow (CRTA)
Leonard P. Kubben Ph.D. Research Fellow
Steve Mabon M.S. Research Biologist
Karen Meaburn Ph.D. Research Fellow (Contr)
Koh Nakayama Ph.D. Research Collaborator
Madaiah Puttaraju Ph.D. Research Fellow
Andria Schibler Ph.D. Postdoctoral Fellow (CRTA)
Leo Serebryannyy Ph.D. Postdoctoral Fellow (CRTA)
Sigal Shachar Ph.D. Postdoctoral Fellow (Visiting)
Asaf Shilo Ph.D. Postdoctoral Fellow (Visiting)
Frances Anne Tosto B.S. Postbaccalaureate Fellow (CRTA)
Sandra Vidak Ph.D. Postdoctoral Fellow (Visiting)
Reini Fernandez de Luco, Ph.D.
Postdoctoral Fellow
(2007 - 2012)

Group Leader
Institute of Human Molecular Genetics
Montpelier, France

Christine Schmidt, Ph.D.
Christine Schmidt, Ph.D.
Postdoctoral Fellow
(2009 - 2011)

Postdoctoral Fellow
Steve Jackson Lab
The Gurdon Institute
University of Cambridge, UK

Pilar Saladores, B.S.
Postbaccalaureate Fellow
(2008 - 2010)

Ph.D. Student
University of Stuttgart
Stuttgart, Germany

Alexandre Mejat, Ph.D.
Postdoctoral Fellow
(2005 - 2009)

Assistant Professor
University of Lyon
Lyon, France

Nicolas Rascovan, M.S
Predoctoral Fellow
(2008 - 2009)

Ph.D. Student
Rosario National University
Rosario, Argentina

Karen Baranes-Bachar, M.S.
Special Volunteer
(2009)

Ph.D. Student
Tel Aviv University
Tel Aviv, Israel

Sameena Khan, B.S.
Summer Student
(2008 - 2009)

Medical Student
University College Dublin School of Medicine
Dublin, Ireland

Manjari Mazumdar, Ph.D.
Manjari Mazumdar, Ph.D.
Research Fellow
(2003 - 2008)

Assistant Professor
Medical Sciences Program
Indiana University
Bloomington, IN

Takumi Takizawa, M.D., Ph.D.
Takumi Takizawa, M.D., Ph.D.
Research Fellow
(2004 - 2008)

Associate Professor
Graduate School of Medicine
Gunma University
Maebashi, Japan

Michelle Devine, M.S.
Predoctoral Fellow
(2009 - 2010)

Medical Student
University of Texas Southwestern Medical School
Dallas, TX

Evi Soutoglou, Ph.D.
Evi Soutoglou, Ph.D.
Postdoctoral Fellow
(2006 - 2008)

Group Leader
Institute for Genetics and Molecular and Cellular Biology
Centre National de la Recherche Scientifique (CNRS)
Strasbourg, France

Cordelle Tanega, B.S.
Cordelle Tanega, B.S.
Predoctoral Fellow
(2006 - 2008)

Biologist
Chemical Genomics Center
National Center for Advancing Translational Sciences
National Institutes of Health
Rockville, MD

Research

Cell Biology of Genomes

My laboratory studies the cell biology of genomes. We use molecular techniques in conjunction with live-cell microscopy to understand how genomes are organized in intact cells and how the spatial organization of genomes contributes to their function. These studies provide insights into basic biological mechanisms and provide the foundation for novel diagnostic and clinical applications in cancer research.

Defects in genome organization and nuclear architecture are responsible for numerous human diseases including cancer, neurodegenerative disorders, and muscular dystrophies and they have recently been linked to human aging. We are using several differentiation and disease models, including embryonic and adult stem cells, to elucidate how genome organization contributes to physiological processes and disease, particularly cancer and aging.

Postdoctoral Fellowships
The Cell Biology of Genomes Group periodically has openings for outstanding postdoctoral fellows. Please send your C.V. and statement of interest to mistelit@mail.nih.gov

Scientific Focus Areas:
Cancer Biology, Chromosome Biology, Molecular Biology and Biochemistry

Publications

View Dr. Misteli's PubMed Summary.

Selected Key Publications

  1. Identification of gene positioning factors using high-throughput imaging mapping.
    Shachar S, Voss TC, Pegoraro G, Sciascia N, Misteli T.
    Cell. 162(4): 911-23, 2015. [ Journal Article ]
  2. Spatial dynamics of chromosome translocations in living cells.
    Roukos V, Voss TC, Schmidt CK, Lee S, Wangsa D, Misteli T.
    Science. 341: 660-4, 2013. [ Journal Article ]
  3. Regulation of alternative splicing by histone modifications.
    Luco RF, Pan Q, Tominaga K, Blencowe BJ, Pereira-Smith OM, Misteli T.
    Science. 327: 996-1000, 2010. [ Journal Article ]
  4. Lamin A-dependent nuclear defects in human aging.
    Scaffidi P, Misteli T.
    Science. 312: 1059-63, 2006. [ Journal Article ]
  5. High mobility of proteins in the mammalian cell nucleus.
    Phair RD, Misteli T.
    Nature. 404: 604-9, 2000. [ Journal Article ]

Biography

Tom Misteli is an internationally renowned pioneer in the field of genome cell biology. He trained at the University of London, UK, and the Cold Spring Harbor Laboratory, NY, where he initiated the use of imaging approaches to study genomes in living cells. His laboratory aims to uncover fundamental principles of higher order genome organization and to apply this knowledge to the development of novel diagnostic and therapeutic strategies for cancer and aging. He has received numerous awards for his work, acts as an advisor for several national and international agencies and serves on numerous editorial boards. He has received numerous awards including the Gian Tondury Award, the Gold Medal of The Charles University, the 2012 Flemming Award, The Wilhem Bernhard Medal and the Herman Beerman Award.

Team

Name Position
Hesam Babahosseini Ph.D. Postdoctoral Fellow (Visiting)
Emily DeBoy Special Volunteer
Marina Feric Ph.D. Postdoctoral Fellow (CRTA)
Elizabeth Finn Ph.D. Postdoctoral Fellow (CRTA)
Predrag Jevtic Ph.D. Research Collaborator
Ziad Jowhar B.S. Postbaccalaureate Fellow (CRTA)
Leonard P. Kubben Ph.D. Research Fellow
Steve Mabon M.S. Research Biologist
Karen Meaburn Ph.D. Research Fellow (Contr)
Koh Nakayama Ph.D. Research Collaborator
Madaiah Puttaraju Ph.D. Research Fellow
Andria Schibler Ph.D. Postdoctoral Fellow (CRTA)
Leo Serebryannyy Ph.D. Postdoctoral Fellow (CRTA)
Sigal Shachar Ph.D. Postdoctoral Fellow (Visiting)
Asaf Shilo Ph.D. Postdoctoral Fellow (Visiting)
Frances Anne Tosto B.S. Postbaccalaureate Fellow (CRTA)
Sandra Vidak Ph.D. Postdoctoral Fellow (Visiting)

Alumni

Reini Fernandez de Luco, Ph.D.
Postdoctoral Fellow
(2007 - 2012)

Group Leader
Institute of Human Molecular Genetics
Montpelier, France

Christine Schmidt, Ph.D.
Christine Schmidt, Ph.D.
Postdoctoral Fellow
(2009 - 2011)

Postdoctoral Fellow
Steve Jackson Lab
The Gurdon Institute
University of Cambridge, UK

Pilar Saladores, B.S.
Postbaccalaureate Fellow
(2008 - 2010)

Ph.D. Student
University of Stuttgart
Stuttgart, Germany

Alexandre Mejat, Ph.D.
Postdoctoral Fellow
(2005 - 2009)

Assistant Professor
University of Lyon
Lyon, France

Nicolas Rascovan, M.S
Predoctoral Fellow
(2008 - 2009)

Ph.D. Student
Rosario National University
Rosario, Argentina

Karen Baranes-Bachar, M.S.
Special Volunteer
(2009)

Ph.D. Student
Tel Aviv University
Tel Aviv, Israel

Sameena Khan, B.S.
Summer Student
(2008 - 2009)

Medical Student
University College Dublin School of Medicine
Dublin, Ireland

Manjari Mazumdar, Ph.D.
Manjari Mazumdar, Ph.D.
Research Fellow
(2003 - 2008)

Assistant Professor
Medical Sciences Program
Indiana University
Bloomington, IN

Takumi Takizawa, M.D., Ph.D.
Takumi Takizawa, M.D., Ph.D.
Research Fellow
(2004 - 2008)

Associate Professor
Graduate School of Medicine
Gunma University
Maebashi, Japan

Michelle Devine, M.S.
Predoctoral Fellow
(2009 - 2010)

Medical Student
University of Texas Southwestern Medical School
Dallas, TX

Evi Soutoglou, Ph.D.
Evi Soutoglou, Ph.D.
Postdoctoral Fellow
(2006 - 2008)

Group Leader
Institute for Genetics and Molecular and Cellular Biology
Centre National de la Recherche Scientifique (CNRS)
Strasbourg, France

Cordelle Tanega, B.S.
Cordelle Tanega, B.S.
Predoctoral Fellow
(2006 - 2008)

Biologist
Chemical Genomics Center
National Center for Advancing Translational Sciences
National Institutes of Health
Rockville, MD

Resources

Genome organization factor determines the few cells that make a tumor grow
Through the high-tech looking glass