Dennis D. Hickstein, M.D.
Dr. Hickstein’s laboratory is working on the recently described bone failure syndrome GATA2 deficiency. In particular, the lab is investigating mutations outside of the GATA2 exons in patients with MonoMAC syndrome, mutations associated with myeloid transformation in patients with GATA2 deficiency who have evidence of myeloid progression, and developing new approaches to the treatment of GATA2 deficiency with hematopoietic stem cell transplantation. These studies are carried out in animal models of disease and in human clinical trials.
1) GATA2 deficiency, 2) bone marrow transplantation, 3) myelodysplastic syndrome
The research in our laboratory revolves around unanswered questions in the newly described bone marrow failure syndrome GATA2 deficiency.
Selected Key Publications
- J Allergy Clinical Immunology. 138(2): 628-630, 2016. [ Journal Article ]
- Biol Blood Marrow Transplant. 21(6): 1037-45, 2015. [ Journal Article ]
- Blood. 130(12): 1391-93, 2017. [ Journal Article ]
Haploidentical related donor hematopoietic stem cell transplantation for DOCK8 deficiency using post-transplant cyclophosphamide.Biol Blood Marrow Transplant. 23(6): 980-90, 2017. [ Journal Article ]
Allogeneic Hematopoietic Stem Cell Transplantation for GATA2 Deficiency Using a Busulfan-Based Regimen.Biol Blood Marrow Transplant. 24(6): 1250-59, 2018. [ Journal Article ]
Dr. Hickstein trained in hematology and hematopoietic stem cell transplantation at the University of Washington School of Medicine and the Fred Hutchinson Cancer Research center. He was a faculty member of the Division of hematology at the University of Washington from 1987 to 2000. He was recruited to the NCI in 2000 to transplant newly identifed primary immunodeficiency diseases.He is a member of the American Society for Clinical Investigation and the American Society of Hematology.
|Thomas R. Bauer Jr., Ph.D.||Staff Scientist|
|Lisa J. Embree||Research Biologist|
|Julia Scheiermann Ph.D.||Postdoctoral Fellow (Visiting)|
|Laura Tuschong||Research Biologist|
|Robert West Ph.D.||Research Biologist|
Dr. Sabaawy is now an Associate Professor at Robert Woods Johnson Medical School in New jersey.
Dr. Shive is now an Assistant Professor in the Department of Veterinary Medicine at North Carolina State University.
Dr. Mizuki Azuma is now an Associate Professor at the University of Kansas