Dennis D. Hickstein, M.D.

Dennis D. Hickstein, M.D.
Senior Investigator
Head, Molecular Oncology and Gene Transfer Section

Dr. Hickstein’s laboratory is working on the recently described bone failure syndrome GATA2 deficiency. In particular, the lab is investigating mutations outside of the GATA2 exons in patients with MonoMAC syndrome, mutations associated with myeloid transformation in patients with GATA2 deficiency who have evidence of myeloid progression, and developing new approaches to the treatment of GATA2 deficiency with hematopoietic stem cell transplantation. These studies are carried out in animal models of disease and in human clinical trials.

Areas of Expertise

1) GATA2 deficiency, 2) bone marrow transplantation, 3) myelodysplastic syndrome

Contact Info

Dennis D. Hickstein, M.D.
Center for Cancer Research
National Cancer Institute
Building 10 - Hatfield CRC, Room 3-3142
Bethesda, MD 20892-1203
Ph: 240-760-6169


The research in our laboratory revolves around unanswered questions in the newly described bone marrow failure syndrome GATA2 deficiency.


NIH Scientific Focus Areas:
Cancer Biology, Genetics and Genomics, Stem Cell Biology
View Dr. Hickstein's PubMed Summary.

Selected Key Publications

  1. Hickstein , Dennis (NIH/NCI) [E]
    J Allergy Clinical Immunology. 138(2): 628-630, 2016. [ Journal Article ]
  2. Cuellar-Rodriguez J, Freeman AF, Grossman J, Su H, Parta M, Murdock H, Shah N, Bollard C, Kong HH, Moutsopoulos N, Stone K, Gea-Banacloche J, Holland SM, Hickstein DD.
    Biol Blood Marrow Transplant. 21(6): 1037-45, 2015. [ Journal Article ]
  3. Hickstein DD, Notarangelo L.
    Blood. 130(12): 1391-93, 2017. [ Journal Article ]
  4. Shah NN, Freeman AF, Su H, Cole K, Parta M, Moutsopoulos NM, Baris S, Karakoc-Aydiner E, Hughes TE, Kong HH, Holland SM, Hickstein DD.
    Biol Blood Marrow Transplant. 23(6): 980-90, 2017. [ Journal Article ]
  5. Parta M, Shah NN, Baird K, Rafei H, Calvo KR, Hughes T, Cole K, Kenyon M, Schuver BB, Cuellar-Rodriguez J, Zerbe CS, Holland SM, Hickstein DD.
    Biol Blood Marrow Transplant. 24(6): 1250-59, 2018. [ Journal Article ]

Dr. Hickstein trained in hematology and hematopoietic stem cell transplantation at the University of Washington School of Medicine and the Fred Hutchinson Cancer Research center. He was a faculty member of the Division of hematology at the University of Washington from 1987 to 2000. He was recruited to the NCI in 2000 to transplant newly identifed primary immunodeficiency diseases.He is a member of the American Society for Clinical Investigation and the American Society of Hematology. 

Name Position
Thomas R. Bauer Jr., Ph.D. Staff Scientist
Lisa J. Embree Research Biologist
Julia Scheiermann Ph.D. Postdoctoral Fellow (Visiting)
Laura Tuschong Research Biologist
Robert West Ph.D. Research Biologist
Hatem Sabaawy Post-doctoral fellow 2002- 2007

Dr. Sabaawy is now an Associate Professor at Robert Woods Johnson Medical School in New jersey. 

Dr. Heather Shive
Heather Shive Staff Scientist 2010-2014

Dr. Shive is now an Assistant Professor in the Department of Veterinary Medicine at North Carolina State University. 

Mizuki Azuma Staff Scientist 2003-2008

Dr. Mizuki Azuma is now an Associate Professor at the University of Kansas