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Thomas R. Bauer Jr., Ph.D.

Thomas R. Bauer Jr., Ph.D.

  • Center for Cancer Research
  • National Cancer Institute

RESEARCH SUMMARY

Dr. Bauer has been working for more than a decade towards gene therapy to treat a childhood immunodeficiency disease known as leukocyte adhesion deficiency (LAD).  Patients with LAD have defects in their leukocyte integrin CD18 gene, which leads to defective leukocytes that are unable to adhere to and migrate to sites of bacterial infection.  In dogs that have canine leukocyte adhesion deficiency (CLAD), Dr. Bauer and his colleagues have shown that by using gene transfer of the canine CD18, they are able to correct the CD18 defect in canine leukocytes, both in vitro and in vivo, leading to dogs that are free of their CLAD disease.

Areas of Expertise

1) leukocyte adhesion deficiency (LAD) 2) canine leukocyte adhesion deficiency (CLAD) 3) gene transfer 4) leukocytes

Publications

Selected Recent Publications

Long-term follow-up of foamy viral vector-mediated gene therapy for canine leukocyte adhesion deficiency

Bauer, Jr. TR, Tuschong LM, Calvo KR, Shive HR, Burkholder TH, Karlsson EK, West RR, Russell DW, Hickstein DD.
Mol Ther. 21: 964-72, 2013. [ Journal Article ]

Leukocyte integrin activation mediates transient neutropenia after G-CSF administration

Donahue RE, Tuschong L, Bauer, Jr. TR, Yau YY, Leitman SF, Hickstein DD.
Blood. 118: 4209-14, 2011. [ Journal Article ]

Gene therapy for canine leukocyte adhesion deficiency with lentiviral vectors using the murine stem cell virus and human phosphoglycerate kinase promoters

Hunter MJ, Zhao H, Tuschong LM, Bauer, Jr. TR, Burkholder TH, Persons DA, Hickstein DD.
Hum Gene Ther. 22: 689-96, 2011. [ Journal Article ]

Treatment of canine leukocyte adhesion deficiency by foamy virus vectors expressing CD18 from a PGK promoter

Bauer, Jr. TR, Olson EM, Huo Y, Tuschong LM, Allen JM, Li Y, Burkholder TH, Russell DW.
Gene Ther. 18: 553-9, 2011. [ Journal Article ]

Gene therapy of canine leukocyte adhesion deficiency using lentiviral vectors with human CD11b and CD18 promoters driving canine CD18 expression

Hunter MJ, Tuschong LM, Fowler CJ, Bauer, Jr. TR, Burkholder TH, Hickstein DD.
Mol Ther. 19: 113-21, 2011. [ Journal Article ]