Dennis D. Hickstein, M.D.

Dennis D. Hickstein, M.D.
Senior Investigator
Head, Molecular Oncology and Gene Transfer Section

Dr. Hickstein’s laboratory is working on the recently described bone failure syndrome GATA2 deficiency. In particular, the lab is investigating mutations outside of the GATA2 exons in patients with MonoMAC syndrome, mutations associated with myeloid transformation in patients with GATA2 deficiency who have evidence of myeloid progression, and developing new approaches to the treatment of GATA2 deficiency with hematopoietic stem cell transplantation. These studies are carried out in animal models of disease and in human clinical trials.

Areas of Expertise
1) GATA2 deficiency 2) bone marrow transplantation 3) myelodysplastic syndrome

Contact Info

Dennis D. Hickstein, M.D.
Center for Cancer Research
National Cancer Institute
Building 10 - Hatfield CRC, Room 3-3142
Bethesda, MD 20892-1203
Ph: 301-594-1718
hicksted@mail.nih.gov

 

The research in our laboratory revolves around unanswered questions in the newly described bone marrow failure syndrome GATA2 deficiency.

 

Scientific Focus Areas:
Cancer Biology, Genetics and Genomics, Stem Cell Biology
View Dr. Hickstein's PubMed Summary.

Selected Key Publications

  1. Jennifer Cuellar-Rodriguez, M.D., Alexandra F. Freeman, M.D., Jennifer Grossman, M.D., Helen Su, M.D., Ph.D., Mark Parta, M.D., Heardley Murdock, B.S., Nirali Shah, M.D., Catherine Bollard, M.D., Heidi Kong, M.D., Niki Moutsopoulos, D.V.M., Kelly Stone, M.D., Ph.D., Juan Gea-Banacloche, M.D., Steven M. Holland, M.D., and Dennis D. Hickstein, M.D.
    Biol Blood and Marrow Transplantation. [Epub ahead of print, Jan. 27]: 2015. [ Journal Article ]
  2. Adenosine deaminase deficiency type 2 deficiency masquerading as GATA2 deficiency.
    Hickstein , Dennis (NIH/NCI) [E]
    J Allergy Clinical Immunology. 138(2): 628-630, 2016. [ Journal Article ]
  3. Jennifer Grossman, Jennifer Cuellar-Rodriguez, Juan Gea-Banacloche, Christa Zerbe, Katherine Calvo, Thomas Hughes, Kristen Cole, Mark Parta, Alexandra Freeman, Steven M. Holland, Dennis D. Hickstein
    Biol Blood and Marrow Transplantation. 20(12): 1940-1948, 2014. [ Journal Article ]
  4. Transplant for NEMO: this and much, much more.
    Hickstein , Dennis (NIH/NCI) [E]
    BLOOD. 130 (12): 1391-1393, 2017. [ Journal Article ]
  5. Heather R. Shive, Robert R. West, Lisa J. Embree, Champa D. Golden, and Dennis D. Hickstein
    PLOS One. 9(1): e87177, 2014. [ Journal Article ]

Dr. Hickstein trained in hematology and hematopoietic stem cell transplantation at the University of Washington School of Medicine and the Fred Hutchinson Cancer Research center. He was a faculty member of the Division of hematology at the University of Washington from 1987 to 2000. He was recruited to the NCI in 2000 to transplant newly identifed primary immunodeficiency diseases.He is a member of the American Society for Clinical Investigation and the American Society of Hematology. 

Name Position
Thomas R. Bauer Jr., Ph.D. Staff Scientist
Lisa J. Embree Research Biologist
Hind Rafei M.D. Special Volunteer
Julia Scheiermann Ph.D. Postdoctoral Fellow (Visiting)
Laura Tuschong Research Biologist
Robert West Ph.D. Research Biologist
Hatem Sabaawy Post-doctoral fellow 2002- 2007

Dr. Sabaawy is now an Associate Professor at Robert Woods Johnson Medical School in New jersey. 

Dr. Heather Shive
Heather Shive Staff Scientist 2010-2014

Dr. Shive is now an Assistant Professor in the Department of Veterinary Medicine at North Carolina State University. 

Mizuki Azuma Staff Scientist 2003-2008

Dr. Mizuki Azuma is now an Associate Professor at the University of Kansas