National Medical Laboratory Professionals Week

photo collage 

 

Targeted Photoimmunotherapy Approach for Cancer Moves Forward

Posted: Apr 26, 2016

Two new studies from NCI researchers add to growing evidence of the promise of a novel type of cancer immunotherapy that uses infrared light to activate rapid and selective killing of cancer cells.

Childhood Cancer Talk Radio Interviews Dr. Kathy Warren

Posted: Apr 13, 2016

Childhood Cancer Talk Radio (Jack’s Angels Foundation) talks to Dr. Kathy Warren about her work and research into solutions for diffuse intrinsic pontine glioma (DIPG), one of the deadliest and most elusive brain tumors to treat.

Figure 1. FoxA graphic

Dynamic Regulation of FoxA1 by Steroid Receptors

Posted: Apr 8, 2016

The estrogen receptor (ER) is a key regulator in breast cancer initiation and progression. A widely discussed model proposes that forkhead box protein A1 (FoxA1) acts as a pioneer factor in cancer by binding and penetrating closed chromatin to allow access by transcription factors (TFs), including ER.

Celebrate Diversity Month

Posted: Apr 4, 2016

We are committed to increasing diversity in our workforce.  Learn more...

Celebrating Women's History Month

Posted: Apr 1, 2016

CCR's women are leading the way in the fight against cancer! Honoring our esteemed female senior Investigators!

Disrupted splicing of the EWS-FLI1 mRNA alters EWS-FLI1 oncoprotein expression and reverses EWS-FLI1 driven transcription

RNA Processing is a Potential Therapeutic Target in Ewing Sarcoma

Posted: Mar 22, 2016

An aggressive cancer of the bone and soft tissue, Ewing sarcoma (ES) is most commonly diagnosed in adolescents and young adults.

NASH Scheme

Selective CD4+ T Cell Loss Promotes Liver Cancer Development

Posted: Mar 4, 2016

Hepatocellular carcinoma (HCC), the second leading cause of cancer deaths worldwide, commonly develops in patients with underlying chronic liver disease, such as hepatitis B or C virus infection or non-alcoholic fatty liver disease (NAFLD).

Immunofluorescent detection of gamma-H2AX in tumor biopsies

Early Clinical Trial Results of New Targeted Ovarian Cancer Therapy

Posted: Feb 22, 2016

While ovarian cancer is fairly uncommon, comprising 1.3 percent of new cancer diagnoses in the U.S., the disease is actually the fifth leading cause of cancer-related deaths in U.S. women.

Hypothetical model for the role of H2A.X in EMT and metastasis

Histone Variant H2A.X Regulates Colon Cancer EMT

Posted: Feb 17, 2016

To spread to distant organs, cancer cells sever contacts with surrounding cells, disrupt their internal polarity, and adopt spindle-like protrusions.

Structure of the CorA magnesium channel in closed (left) and open (right) states

Surprising Loss of Symmetry of Magnesium Channel CorA Upon Gating

Posted: Feb 17, 2016

Magnesium ions (Mg2+) play essential roles in all living organisms. Bacteria and other prokaryotes rely upon the Mg2+-dependent channel CorA, which is composed of five identical subunits (A-E), to obtain these ions from their surroundings.

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