Tom Misteli, Ph.D.
- Center for Cancer Research
- National Cancer Institute
- Building 41, Room B610
- Bethesda, MD 20892
- 240-760-6669
- mistelit@mail.nih.gov
- @NCITomMisteli
RESEARCH SUMMARY
Tom Misteli is an internationally renowned cell biologist who pioneered the use of imaging approaches to study genomes and gene expression. His laboratory uses cell biological, molecular, biochemical and imaging approaches to uncover fundamental principles of genome architecture and to apply this knowledge to the development of novel diagnostic and therapeutic strategies for cancer and aging.
Areas of Expertise
Research
Cell Biology of Genomes
My laboratory studies the cell biology of genomes. We use molecular techniques in conjunction with live-cell microscopy to understand how genomes are organized in intact cells and how the spatial organization of genomes contributes to their function. These studies provide insights into basic biological mechanisms and establish the foundation for novel diagnostic and clinical applications in cancer research.
Defects in genome organization and nuclear architecture are responsible for numerous human diseases including cancer, neurodegenerative disorders, and muscular dystrophies and they have been linked to human aging. We are using several differentiation and disease models to elucidate how genome organization contributes to physiological processes and disease, particularly in cancer and aging.
Postdoctoral Fellowships
The Cell Biology of Genomes Group has an opening for an outstanding postdoctoral fellow to explore synthetic biology and bioengineering approaches to genome organization. Please send your C.V. and statement of interest to mistelit@mail.nih.gov
Summer Students
This year's summer internship positions have been filled. Thank you for your interest in our work.
Publications
- Bibliography Link
- View Dr. Misteli's PubMed Summary.
Extensive Heterogeneity and Intrinsic Variation in Spatial Genome Organization.
Repression of the Antioxidant NRF2 Pathway in Premature Aging
Identification of gene positioning factors using high-throughput imaging mapping
Spatial dynamics of chromosome translocations in living cells
Regulation of alternative splicing by histone modifications
Biography
Tom Misteli, Ph.D.
Tom Misteli is an internationally renowned pioneer in the field of genome cell biology. He trained at the University of London, UK, and the Cold Spring Harbor Laboratory, NY, where he initiated the use of imaging approaches to study genomes in living cells. His laboratory aims to uncover fundamental principles of higher order genome organization and to apply this knowledge to the development of novel diagnostic and therapeutic strategies for cancer and aging. He has received numerous awards for his work, acts as an advisor for several national and international agencies and serves on numerous editorial boards. He has received numerous awards including the Gian Tondury Award, the Gold Medal of The Charles University, the 2012 Flemming Award, The Wilhem Bernhard Medal and the Herman Beerman Award.
