Natalie Porat-Shliom, Ph.D.
Dr. Porat-Shliom is a cell biologist with expertise in light microscopy techniques, particularly, intravital microscopy. Her lab uses a combination of molecular, biochemical and imaging approaches to investigate the principles underlying mitochondrial structure and function and the changes under pathological conditions such as cellular transformation.
1) mitochondria biology, 2) intravital microscopy, 3) signal transduction, 4) liver physiology, 5) metabolism
Cells must rewire their metabolic programs to satisfy energy demands of growth and proliferation. The mitochondria confer this flexibility including alterations in fuel utilization, bioenergetics, and cell death susceptibility. Transformed cells exploit this plasticity to survive in adverse environmental conditions such as nutrient and/or oxygen deprivation and during chemotherapy. The general theme of the Porat-Shliom lab is to understand how normal and malignant cells metabolically adapt to changes in nutrient availability and energy demand. Towards this goal, we combine light microscopy approaches, particularly intravital microscopy and mouse genetics to study mitochondrial structure and function in intact tissues with a specific focus on the liver. These studies offer insights into basic biological mechanisms, their implications in cellular transformation and provide the foundation for novel diagnostic and clinical applications in cancer research.
Selected Key Publications
Mitochondrial populations exhibit differential dynamic responses to increased energy demand during exocytosis in vivo.iScience. 11: 440–449, 2019. [ Journal Article ]
- Cell Systems. 4: 277–290, 2017. [ Journal Article ]
- Hepatology. 64(4): 1317-29, 2016. [ Journal Article ]
- Cell Rep. 9(2): 514-521, 2014. [ Journal Article ]
- J Cell Biol. 201(7): 969-979, 2013. [ Journal Article ]
Dr. Porat-Shliom received her B.Sc. in biology, M.Sc. in neurobiology and Ph.D. in cell biology from Tel-Aviv University, Israel. Her Ph.D. research was performed at the NIH, through the Graduate Partnerships Program, under the supervision of Prof. Yoel Kloog (Tel Aviv University) and Dr. Julie Donaldson (NHLBI, NIH). For her postdoctoral training, Dr. Porat-Shliom joined the laboratory of Dr. Roberto Weigert (NCI, NIH) where she specialized in intravital microscopy studying mitochondria in the salivary gland for which she received the NIH Pathway to independence Award (K99/R00). In 2018, Dr. Porat-Shliom joined as a Tenure Track Investigator.