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Dr. Natalie Porat-Shliom

Natalie Porat-Shliom, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Stadtman Investigator
Thoracic and GI Malignancies Branch
Head, Cell Biology and Imaging Section

RESEARCH SUMMARY

Dr. Porat-Shliom is a cell biologist specializing in advanced light microscopy techniques, with a particular focus on intravital microscopy. Her laboratory employs an integrative approach, combining molecular biology, biochemistry, and cutting-edge imaging methods to examine the fundamental principles of liver zonation. Ultimately, her research provides insights into the role of tissue-level compartmentalization in physiology and pathological conditions such as Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), and liver cancer.

Areas of Expertise

Mitochondria Biology
Intravital Microscopy
Liver Physiology

CCR Liver Cancer Program

A multidisciplinary research network dedicated to improving early detection, diagnosis, prognosis and treatment of liver cancer.

Publications

A spatial map of hepatic mitochondria uncovers functional heterogeneity shaped by nutrient-sensing signaling

Sun Woo Sophie Kang, Rory P. Cunningham, Colin B. Miller, Lauryn A. Brown, Constance M. Cultraro, Adam Harned, Kedar Narayan, Jonathan Hernandez, Lisa M. Jenkins, Alexei Lobanov, Maggie Cam & Natalie Porat-Shliom
Nature Communications. 2024.
Full-Text Article
[ Journal Article ]

Compartmentalization, cooperation, and communication: The 3Cs of Hepatocyte zonation

Porat-Shliom N
Curr Opin Cell Biol. 2024. [ Journal Article ]

LKB1 acts as a critical brake for the glucagon-mediated fasting response

Suehelay Acevedo-Acevedo,Megan L. Stefkovich,Sun Woo Sophie Kang,Rory P. Cunningham,Constance M. Cultraro,Natalie Porat-Shliom
Hepatology Communications. 2022.
Full-Text Article
[ Journal Article ]

Liver Zonation - Revisiting Old Questions With New Technologies

Rory P Cunningham and Natalie Porat-Shliom
Front Physiol.. 2021.
Full-Text Article
[ Journal Article ]

Intravital Microscopy for the Study of Hepatic Glucose Uptake

Megan L Stefkovich, Sun Woo Sophie Kang, Natalie Porat-Shliom
Curr Protoc. 1(5): e139, 2020.
Full-Text Article
[ Journal Article ]

Job Vacancies

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Team

Lauryn Brown
Post Baccalaureate Fellow (IRTA/CRTA)
Lauryn Brown, B.S.
CMC
Senior Research Assistant
Constance M Cultraro, Ph.D.

News

Picture of the Day

May 17, 2024 - Our work on mitochondria zonation in the liver was highlighted in BPoD Biomedical picture of the day.