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Shiv Grewal, Ph.D.

Shiv Grewal, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute

RESEARCH SUMMARY

Shiv Grewal has uncovered groundbreaking insights into heterochromatin assembly and epigenetic control of the genome. In addition to revealing that distinct histone methylation patterns define heterochromatin (closed) and euchromatin (open) regions of the genome, he has discovered fundamental mechanisms that target heterochromatin to repetitive elements and other locations throughout the genome. In particular, his discovery of the role of RNAi in heterochromatin formation was cited as “Breakthrough of the Year” (Science, 2002). He has further defined critical requirements for the epigenetic inheritance of heterochromatin domains and described how heterochromatin performs diverse regulatory functions to promote genome stability, adaptive gene control and 3D genome organization.

Areas of Expertise

(1) Heterochromatin assembly and functions, (2) epigenetic inheritance, (3) RNA-mediated chromatin modifications, (4) adaptive control of the genome, (5) signaling to chromatin, (6) genome stability

Publications

Selected Recent Publications

Positioning Heterochromatin at the Nuclear Periphery Suppresses Histone Turnover to Promote Epigenetic Inheritance

Holla S, Dhakshnamoorthy J, Folco HD, Balachandran V, Xiao H, Sun LL, Wheeler D, Zofall M, Grewal SIS.
Cell. 180(1): 150-164, 2020. [ Journal Article ]

CPF Recruitment to Non-canonical Transcription Termination Sites Triggers Heterochromatin Assembly and Gene Silencing

Vo TV, Dhakshnamoorthy J, Larkin M, Zofall M, Thillainadesan G, Balachandran V, Holla S, Wheeler D, Grewal SIS.
Cell Rep. 28(1): 267-81, 2019. [ Journal Article ]

A conserved dimer interface connects ERH and YTH family proteins to promote gene silencing

Xie G, Vo TV, Thillainadesan G, Holla S, Zhang B, Jiang Y, Lv M, Xu Z, Wang C, Balachandran V, Shi Y, Li F, Grewal SIS.
Nat Commun. 10(1): 251, 2019. [ Journal Article ]

Iron homeostasis regulates facultative heterochromatin assembly in adaptive genome control

Gallagher PS, Larkin M, Thillainadesan G, Dhakshnamoorthy J, Balachandran V, Xiao H, Wellman C, Chatterjee R, Wheeler D, Grewal SIS
Nat Struct Mol Biol. 25(5): 372-383, 2018. [ Journal Article ]

Untimely expression of gametogenic genes in vegetative cells causes uniparental disomy

Folco HD, Chalamcharla VR, Sugiyama T, Thillainadesan G, Zofall M, Balachandran V, Dhakshnamoorthy J, Mizuguchi T, Grewal SI
Nature. 543(7643): 126-130, 2017. [ Journal Article ]

Job Vacancies

Position Degree Required Contact Name Contact Email
Post-doctoral Fellow - Heterochromatin assembly, epigenetic inheritance Ph.D. or equivalent Shiv Grewal grewals@mail.nih.gov

Team

Laboratory Technician (Contr)
Jothy Dhakshnamoorthy, M.S.
Postdoctoral Fellow (Visiting)
Sahana Holla, Ph.D.
Postdoctoral Fellow (Visiting)
Patroula Nathanailidou, Ph.D.
Postdoctoral Fellow (Visiting)
Manjit Srivastav, Ph.D.
Postdoctoral Fellow (Visiting)
Yi Wei, Ph.D.
Lab Technician (Contr)
Christopher Wellman
Biologist
Hua Xiao, Ph.D.
Staff Scientist
Martin Zofall, Ph.D.
Postdoctoral Fellow (Visiting)
Drisya Vijayakumari, Ph.D.
Postbaccalaureate Fellow (CRTA)
Jaydeep Sangha, B.A.
Postbaccalaureate Fellow (CRTA)
Alexander Gottfried, B.A.
Postdoctoral Fellow (Visiting)
Bharat Bhatt, Ph.D.
Research Fellow
Rima Sandhu, Ph.D.
Postdoctoral Fellow (Visiting)
Rakesh Sahu, Ph.D.