Shiv Grewal, Ph.D.

Shiv Grewal, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute


Shiv Grewal has uncovered groundbreaking insights into heterochromatin assembly and epigenetic control of the genome. In addition to revealing that distinct histone methylation patterns define heterochromatin (closed) and euchromatin (open) regions of the genome, he has discovered fundamental mechanisms that target heterochromatin to repetitive elements and other locations throughout the genome. In particular, his discovery of the role of RNAi in heterochromatin formation was cited as “Breakthrough of the Year” (Science, 2002). He has further defined critical requirements for the epigenetic inheritance of heterochromatin domains and described how heterochromatin performs diverse regulatory functions to promote genome stability, adaptive gene control and 3D genome organization.

Areas of Expertise

Heterochromatin Assembly and Functions
Epigenetic Inheritance
RNA-Mediated Chromatin Modifications
Adaptive Control of the Genome
Signaling To Chromatin


Selected Recent Publications

Positioning Heterochromatin at the Nuclear Periphery Suppresses Histone Turnover to Promote Epigenetic Inheritance

Holla S, Dhakshnamoorthy J, Folco HD, Balachandran V, Xiao H, Sun LL, Wheeler D, Zofall M, Grewal SIS.
Cell. 180(1): 150-164, 2020. [ Journal Article ]

CPF Recruitment to Non-canonical Transcription Termination Sites Triggers Heterochromatin Assembly and Gene Silencing

Vo TV, Dhakshnamoorthy J, Larkin M, Zofall M, Thillainadesan G, Balachandran V, Holla S, Wheeler D, Grewal SIS.
Cell Rep. 28(1): 267-81, 2019. [ Journal Article ]

A conserved dimer interface connects ERH and YTH family proteins to promote gene silencing

Xie G, Vo TV, Thillainadesan G, Holla S, Zhang B, Jiang Y, Lv M, Xu Z, Wang C, Balachandran V, Shi Y, Li F, Grewal SIS.
Nat Commun. 10(1): 251, 2019. [ Journal Article ]

Iron homeostasis regulates facultative heterochromatin assembly in adaptive genome control

Gallagher PS, Larkin M, Thillainadesan G, Dhakshnamoorthy J, Balachandran V, Xiao H, Wellman C, Chatterjee R, Wheeler D, Grewal SIS
Nat Struct Mol Biol. 25(5): 372-383, 2018. [ Journal Article ]

Untimely expression of gametogenic genes in vegetative cells causes uniparental disomy

Folco HD, Chalamcharla VR, Sugiyama T, Thillainadesan G, Zofall M, Balachandran V, Dhakshnamoorthy J, Mizuguchi T, Grewal SI
Nature. 543(7643): 126-130, 2017. [ Journal Article ]

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Laboratory Technician (Contr)
Jothy Dhakshnamoorthy, M.S.
Postdoctoral Fellow (Visiting)
Sahana Holla, Ph.D.
Postdoctoral Fellow (Visiting)
Patroula Nathanailidou, Ph.D.
Postdoctoral Fellow (Visiting)
Manjit Srivastav, Ph.D.
Hua Xiao, Ph.D.
Staff Scientist
Martin Zofall, Ph.D.
Postdoctoral Fellow (Visiting)
Drisya Vijayakumari, Ph.D.
Postdoctoral Fellow (Visiting)
Ashis Pradhan, Ph.D.
Postdoctoral Fellow (Visiting)
Bharat Bhatt, Ph.D.
Postdoctoral Fellow (Visiting)
Rakesh Sahu, Ph.D.
Laboratory Technician (Contr)
Shweta Jain
Laboratory Technician (Contr)
Shifang (Wendy) Dai
Postdoctoral Fellow (Visiting)
Rakesh Pandian, Ph.D.
Postdoctoral Fellow (Visiting)
Anupa Anil, Ph.D.