H. Diego Folco, Ph.D.

H. Diego Folco, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute


Dr. Folco studies chromosome segregation using fission yeast as model system. He obtained his Ph.D. from the National University of Cordoba (Argentina) and have performed postdoctoral training in Edinburgh (Scotland) and San Diego before joining NCI. Recently, he and colleagues discovered that untimely expression of gametogenic genes drives uniparental disomy (UPD), a phenomenon linked to cancer and other human diseases.

Areas of Expertise

1) chromosome segregation 2) centromere 3) fission yeast genetics 4) epigenetics 5) heterochromatin 6) kinetochore


Selected Key Publications

Untimely expression of gametogenic genes in vegetative cells causes uniparental disomy

Folco HD, Chalamcharla VR, Sugiyama T, Thillainadesan G, Zofall M, Balachandran V, Dhakshnamoorthy J, Mizuguchi T, and Grewal SI.
Nature. 543: 126-130, 2017. [ Journal Article ]

The CENP-A N-tail confers epigenetic stability to centromeres via the CENP-T branch of the CCAN in fission yeast

Folco HD, Campbell C, May KM, Espinoza CA, Oegema K, Hardwick KG, Grewal SI, and Desai A.
Current Biology. 25: 348-356, 2015. [ Journal Article ]

A two-step mechanism for epigenetic specification of centromere identity and function

Fachinetti D, Folco HD, Nechemia-Arbely Y, Valente L, Nguyen K, Wong AJ, Zhu Q, Holland AJ, Desai A, Jansen LE, and Cleveland D.
Nature Cell Biology. 15: 1056-1066 , 2013. [ Journal Article ]

Synthetic heterochromatin bypasses RNAi and centromeric repeats to establish functional centromeres

Kagansky A*, Folco HD*, Almeida R*, Pidoux AL, Boukaba A, Simmer F, Urano T, Hamilton GL, and Allshire RC. *equal contribution
Science. 324: 1716-1719, 2009. [ Journal Article ]

Heterochromatin and RNAi are required to establish CENP-A chromatin at centromeres

Folco HD, Pidoux AL, Urano T, and Allshire RC.
Science. 319: 94-97, 2008. [ Journal Article ]