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Mioara Larion, Ph.D.

Mioara Larion, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Neuro-Oncology Branch

RESEARCH SUMMARY

Dr. Larion is a trained biochemist who is interested in the metabolic needs of cancer cells and how they process nutrients to develop ways to target them and delay tumor growth. She utilizes a set of technologies, of which Raman Imaging Microscopy can quantify patterns in proteins, lipids, and nucleic acids levels at subcellular levels. This is a highly significant endeavor for glioma tumors that are known to exhibit high heterogeneity.

Dr. Larion’s lab is focused on identifying metabolic vulnerabilities in IDH1 mutated gliomas for clinical application as well as on developing technologies that enable these discoveries. Her lab has identified that lipid pathways are important for IDH1-mutant glioma growth and targeting specific enzymes from either fatty acid synthesis or sphingolipid pathway leads to specific cellular death in these cells. She is also interested in developing biomarkers to help image the disease progression and monitor the response to treatments.

Areas of Expertise

1) glioma, 2) metabolism, 3) raman spectroscopy, 4) lipids, 5) neuro-oncology

Publications

Selected Publications

IDH1 mutations induce organelle defects via dysregulated phospholipids.

Lita A, Pliss A, Kuzmin A, Yamasaki T, Zhang L, Dowdy T, Burks C, de Val N, Celiku O, Ruiz-Rodado V, Nicoli ER, Kruhlak M, Andresson T, Das S, Yang C, Schmitt R, Herold-Mende C, Gilbert MR, Prasad PN, Larion M.
Nature Communications. 12(1): 614, 2021. [ Journal Article ]

Toward Single-Organelle Lipidomics in Live Cells.

Lita, A., Kuzmin, A.N., Pliss, A., Baev, A., Rzhevskii, A., Gilbert, M.R., Larion, M.,
Analytical Chemistry. 91(17): 11380-87, 2019. [ Journal Article ]

Sphingolipid Pathway as a Source of Vulnerability in IDH1mut Glioma.

Dowdy T, Zhang L, Celiku O, Movva S, Lita A, Ruiz-Rodado V, Gilbert MR, Larion M.
Cancers. 12(10): 2910, 2020. [ Journal Article ]

Metabolic Reprogramming Associated with Aggressiveness Occurs in the G-CIMP-High Molecular Subtypes of IDH1mut Lower Grade Gliomas

Victor R.R., Malta T.M., Seki T., Lita A., Dowdy T., Celiku O., Cavazos-Saldana A., Li A., Liu Y., Han S., Zhang W., Song H., Davis D., Lee S., Trepel J.B., Sabedot T.S., Munasinghe J., Yang C., Herold-Mende C., Gilbert M.R., Krishna Cherukuri M., Noushmehr H., Larion M.
Neuro-Oncology. [epub ahead of print]: 2019. [ Journal Article ]

Magnetic resonance spectroscopy for the study of CNS malignancies.

Ruiz-Rodado V, Brender JR, Cherukuri MK, Gilbert MR, Larion M.
Progress in Nuclear Magnetic Resonance Spectroscopy. 122: 23-41, 2021. [ Journal Article ]

Job Vacancies

Position Degree Required Contact Name Contact Email
Post-doctoral Fellow - Brain tumors, lipid metabolism, cancer biology Ph.D. or equivalent, M.D. or equivalent Mioara Larion mioara.larion@nih.gov

Team

Laboratory Technician (Contr.)
Tyrone M. Dowdy
Research Fellow
Adrian Lita, Ph.D.
Postdoctoral Fellow (Visiting)
Tomohiro Yamasaki, Ph.D.
Scientist (Contr.)
Lumin Zhang, Ph.D.